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Uterine cancer

MedGen UID:
57791
•Concept ID:
C0153567
•
Neoplastic Process
Synonyms: Cancer of the Uterus; Cancer of Uterus; Cancer, Uterine; Cancer, Uterus; Cancers, Uterine; Cancers, Uterus; Uterine Cancer; Uterine Cancers; Uterus Cancer; Uterus Cancers
SNOMED CT: Malignant neoplasm of uterus (371973000); Malignant tumor of uterus (371973000); CA - Cancer of uterus (371973000); Cancer of uterus (371973000); Uterine cancer (371973000)
 
Monarch Initiative: MONDO:0002715

Definition

Primary or metastatic malignant neoplasm involving the uterine corpus and/or the cervix. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUterine cancer

Professional guidelines

PubMed

NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2024.
Daly MB, Pal T, Maxwell KN, Churpek J, Kohlmann W, AlHilli Z, Arun B, Buys SS, Cheng H, Domchek SM, Friedman S, Giri V, Goggins M, Hagemann A, Hendrix A, Hutton ML, Karlan BY, Kassem N, Khan S, Khoury K, Kurian AW, Laronga C, Mak JS, Mansour J, McDonnell K, Menendez CS, Merajver SD, Norquist BS, Offit K, Rash D, Reiser G, Senter-Jamieson L, Shannon KM, Visvanathan K, Welborn J, Wick MJ, Wood M, Yurgelun MB, Dwyer MA, Darlow SD
J Natl Compr Canc Netw 2023 Oct;21(10):1000-1010. doi: 10.6004/jnccn.2023.0051. PMID: 37856201
Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma.
Concin N, Matias-Guiu X, Vergote I, Cibula D, Mirza MR, Marnitz S, Ledermann J, Bosse T, Chargari C, Fagotti A, Fotopoulou C, Gonzalez Martin A, Lax S, Lorusso D, Marth C, Morice P, Nout RA, O'Donnell D, Querleu D, Raspollini MR, Sehouli J, Sturdza A, Taylor A, Westermann A, Wimberger P, Colombo N, Planchamp F, Creutzberg CL
Int J Gynecol Cancer 2021 Jan;31(1):12-39. Epub 2020 Dec 18 doi: 10.1136/ijgc-2020-002230. PMID: 33397713

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Uterine Neoplasms, 2024

Recent clinical studies

Etiology

Hair relaxer use and risk of uterine cancer in the Black Women's Health Study.
Bertrand KA, Delp L, Coogan PF, Cozier YC, Lenzy YM, Rosenberg L, Palmer JR
Environ Res 2023 Dec 15;239(Pt 1):117228. Epub 2023 Oct 10 doi: 10.1016/j.envres.2023.117228. PMID: 37821068Free PMC Article
Use of Straighteners and Other Hair Products and Incident Uterine Cancer.
Chang CJ, O'Brien KM, Keil AP, Gaston SA, Jackson CL, Sandler DP, White AJ
J Natl Cancer Inst 2022 Dec 8;114(12):1636-1645. doi: 10.1093/jnci/djac165. PMID: 36245087Free PMC Article
Lower extremity lymphedema in patients with gynecologic malignancies.
Dessources K, Aviki E, Leitao MM Jr
Int J Gynecol Cancer 2020 Feb;30(2):252-260. Epub 2020 Jan 7 doi: 10.1136/ijgc-2019-001032. PMID: 31915136Free PMC Article
Gynecologic Malignancies.
Suneja G, Viswanathan A
Hematol Oncol Clin North Am 2020 Feb;34(1):71-89. doi: 10.1016/j.hoc.2019.08.018. PMID: 31739953
Current recommendations and recent progress in endometrial cancer.
Brooks RA, Fleming GF, Lastra RR, Lee NK, Moroney JW, Son CH, Tatebe K, Veneris JL
CA Cancer J Clin 2019 Jul;69(4):258-279. Epub 2019 May 10 doi: 10.3322/caac.21561. PMID: 31074865

Diagnosis

Hair relaxer use and risk of uterine cancer in the Black Women's Health Study.
Bertrand KA, Delp L, Coogan PF, Cozier YC, Lenzy YM, Rosenberg L, Palmer JR
Environ Res 2023 Dec 15;239(Pt 1):117228. Epub 2023 Oct 10 doi: 10.1016/j.envres.2023.117228. PMID: 37821068Free PMC Article
Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
Use of Straighteners and Other Hair Products and Incident Uterine Cancer.
Chang CJ, O'Brien KM, Keil AP, Gaston SA, Jackson CL, Sandler DP, White AJ
J Natl Cancer Inst 2022 Dec 8;114(12):1636-1645. doi: 10.1093/jnci/djac165. PMID: 36245087Free PMC Article
Lower extremity lymphedema in patients with gynecologic malignancies.
Dessources K, Aviki E, Leitao MM Jr
Int J Gynecol Cancer 2020 Feb;30(2):252-260. Epub 2020 Jan 7 doi: 10.1136/ijgc-2019-001032. PMID: 31915136Free PMC Article
Gynecologic Malignancies.
Suneja G, Viswanathan A
Hematol Oncol Clin North Am 2020 Feb;34(1):71-89. doi: 10.1016/j.hoc.2019.08.018. PMID: 31739953

Therapy

The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.
Song Q, Zhou X, Xu K, Liu S, Zhu X, Yang J
Adv Nutr 2023 Nov;14(6):1416-1435. Epub 2023 Aug 22 doi: 10.1016/j.advnut.2023.08.008. PMID: 37619764Free PMC Article
Use of Straighteners and Other Hair Products and Incident Uterine Cancer.
Chang CJ, O'Brien KM, Keil AP, Gaston SA, Jackson CL, Sandler DP, White AJ
J Natl Cancer Inst 2022 Dec 8;114(12):1636-1645. doi: 10.1093/jnci/djac165. PMID: 36245087Free PMC Article
Uterine serous carcinoma.
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Enomoto T, Takehara K, Denys H, Nout RA, Lorusso D, Vaughan MM, Bini M, Takano M, Provencher D, Indini A, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Candido Dos Reis FJ, Lopez S, Mariani A, Leitao MM Jr, Raspagliesi F, Panici PB, Di Donato V, Muzii L, Colombo N, Scambia G, Pignata S, Monk BJ
Gynecol Oncol 2021 Jul;162(1):226-234. Epub 2021 Apr 30 doi: 10.1016/j.ygyno.2021.04.029. PMID: 33934848Free PMC Article
Current recommendations and recent progress in endometrial cancer.
Brooks RA, Fleming GF, Lastra RR, Lee NK, Moroney JW, Son CH, Tatebe K, Veneris JL
CA Cancer J Clin 2019 Jul;69(4):258-279. Epub 2019 May 10 doi: 10.3322/caac.21561. PMID: 31074865
FGF receptors: cancer biology and therapeutics.
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246

Prognosis

Ovarian, Uterine, and Vulvovaginal Cancers: Screening, Treatment Overview, and Prognosis.
Kwolek DG, Gerstberger S, Tait S, Qiu JM
Med Clin North Am 2023 Mar;107(2):329-355. Epub 2023 Jan 2 doi: 10.1016/j.mcna.2022.10.016. PMID: 36759101
Management of stage III and IVa uterine cancer.
Nero C, Tronconi F, Giudice E, Scambia G, Lorusso D
Int J Gynecol Cancer 2022 Mar;32(3):316-322. doi: 10.1136/ijgc-2021-002554. PMID: 35256418
Gynecologic Malignancies.
Suneja G, Viswanathan A
Hematol Oncol Clin North Am 2020 Feb;34(1):71-89. doi: 10.1016/j.hoc.2019.08.018. PMID: 31739953
Risk factors for endometrial cancer: An umbrella review of the literature.
Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M
Int J Cancer 2019 Oct 1;145(7):1719-1730. Epub 2019 Feb 20 doi: 10.1002/ijc.31961. PMID: 30387875
Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States.
Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM
Cancer Res 2014 Jun 1;74(11):2913-21. doi: 10.1158/0008-5472.CAN-14-0155. PMID: 24840647

Clinical prediction guides

Milk consumption and risk of twelve cancers: A large-scale observational and Mendelian randomisation study.
Lumsden AL, Mulugeta A, Hyppönen E
Clin Nutr 2023 Jan;42(1):1-8. Epub 2022 Nov 7 doi: 10.1016/j.clnu.2022.11.006. PMID: 36473423
Use of Straighteners and Other Hair Products and Incident Uterine Cancer.
Chang CJ, O'Brien KM, Keil AP, Gaston SA, Jackson CL, Sandler DP, White AJ
J Natl Cancer Inst 2022 Dec 8;114(12):1636-1645. doi: 10.1093/jnci/djac165. PMID: 36245087Free PMC Article
Artificial intelligence in gynecologic cancers: Current status and future challenges - A systematic review.
Akazawa M, Hashimoto K
Artif Intell Med 2021 Oct;120:102164. Epub 2021 Sep 3 doi: 10.1016/j.artmed.2021.102164. PMID: 34629152
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study.
Vithayathil M, Carter P, Kar S, Mason AM, Burgess S, Larsson SC
PLoS Med 2021 Jul;18(7):e1003706. Epub 2021 Jul 29 doi: 10.1371/journal.pmed.1003706. PMID: 34324486Free PMC Article
Risk factors for endometrial cancer: An umbrella review of the literature.
Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M
Int J Cancer 2019 Oct 1;145(7):1719-1730. Epub 2019 Feb 20 doi: 10.1002/ijc.31961. PMID: 30387875

Recent systematic reviews

Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review.
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Investigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses.
Tanha K, Mottaghi A, Nojomi M, Moradi M, Rajabzadeh R, Lotfi S, Janani L
J Ovarian Res 2021 Nov 11;14(1):153. doi: 10.1186/s13048-021-00911-z. PMID: 34758846Free PMC Article
Artificial intelligence in gynecologic cancers: Current status and future challenges - A systematic review.
Akazawa M, Hashimoto K
Artif Intell Med 2021 Oct;120:102164. Epub 2021 Sep 3 doi: 10.1016/j.artmed.2021.102164. PMID: 34629152
The Effect of Pelvic Floor Muscle Interventions on Pelvic Floor Dysfunction After Gynecological Cancer Treatment: A Systematic Review.
Brennen R, Lin KY, Denehy L, Frawley HC
Phys Ther 2020 Aug 12;100(8):1357-1371. doi: 10.1093/ptj/pzaa081. PMID: 32367126
Risk factors for endometrial cancer: An umbrella review of the literature.
Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M
Int J Cancer 2019 Oct 1;145(7):1719-1730. Epub 2019 Feb 20 doi: 10.1002/ijc.31961. PMID: 30387875

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Uterine Neoplasms, 2024

    Consumer resources

    Reviews

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