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Bone necrosis

MedGen UID:
45249
•Concept ID:
C0029445
•
Pathologic Function
Synonym: Osteonecrosis
 
Monarch Initiative: MONDO:0005380
Orphanet: ORPHA399158

Definition

Death of bone tissue due to traumatic or nontraumatic causes. [from NCI]

Professional guidelines

PubMed

Osteomyelitis: Diagnosis and Treatment.
Bury DC, Rogers TS, Dickman MM
Am Fam Physician 2021 Oct 1;104(4):395-402. PMID: 34652112
Consensus guidelines on the use of bisphosphonate therapy in children and adolescents.
Simm PJ, Biggin A, Zacharin MR, Rodda CP, Tham E, Siafarikas A, Jefferies C, Hofman PL, Jensen DE, Woodhead H, Brown J, Wheeler BJ, Brookes D, Lafferty A, Munns CF; APEG Bone Mineral Working Group
J Paediatr Child Health 2018 Mar;54(3):223-233. doi: 10.1111/jpc.13768. PMID: 29504223
Antiresorptive treatment-associated ONJ.
Eleutherakis-Papaiakovou E, Bamias A
Eur J Cancer Care (Engl) 2017 Nov;26(6) Epub 2017 Oct 24 doi: 10.1111/ecc.12787. PMID: 29063702

Recent clinical studies

Etiology

Osteomyelitis: Diagnosis and Treatment.
Bury DC, Rogers TS, Dickman MM
Am Fam Physician 2021 Oct 1;104(4):395-402. PMID: 34652112
Antiresorptive treatment-associated ONJ.
Eleutherakis-Papaiakovou E, Bamias A
Eur J Cancer Care (Engl) 2017 Nov;26(6) Epub 2017 Oct 24 doi: 10.1111/ecc.12787. PMID: 29063702
Indications and contraindications of dental implants in medically compromised patients: update.
Gómez-de Diego R, Mang-de la Rosa Mdel R, Romero-Pérez MJ, Cutando-Soriano A, López-Valverde-Centeno A
Med Oral Patol Oral Cir Bucal 2014 Sep 1;19(5):e483-9. doi: 10.4317/medoral.19565. PMID: 24608222Free PMC Article
Osteonecrosis.
Pavelka K
Baillieres Best Pract Res Clin Rheumatol 2000 Jun;14(2):399-414. doi: 10.1053/berh.2000.0072. PMID: 10925752
Postoperative sterno-mediastinitis.
Robicsek F
Am Surg 2000 Feb;66(2):184-92. PMID: 10695750

Diagnosis

Osteomyelitis: Diagnosis and Treatment.
Bury DC, Rogers TS, Dickman MM
Am Fam Physician 2021 Oct 1;104(4):395-402. PMID: 34652112
Antiresorptive treatment-associated ONJ.
Eleutherakis-Papaiakovou E, Bamias A
Eur J Cancer Care (Engl) 2017 Nov;26(6) Epub 2017 Oct 24 doi: 10.1111/ecc.12787. PMID: 29063702
Indications and contraindications of dental implants in medically compromised patients: update.
Gómez-de Diego R, Mang-de la Rosa Mdel R, Romero-Pérez MJ, Cutando-Soriano A, López-Valverde-Centeno A
Med Oral Patol Oral Cir Bucal 2014 Sep 1;19(5):e483-9. doi: 10.4317/medoral.19565. PMID: 24608222Free PMC Article
Osteonecrosis.
Pavelka K
Baillieres Best Pract Res Clin Rheumatol 2000 Jun;14(2):399-414. doi: 10.1053/berh.2000.0072. PMID: 10925752
Postoperative sterno-mediastinitis.
Robicsek F
Am Surg 2000 Feb;66(2):184-92. PMID: 10695750

Therapy

Osteomyelitis: Diagnosis and Treatment.
Bury DC, Rogers TS, Dickman MM
Am Fam Physician 2021 Oct 1;104(4):395-402. PMID: 34652112
Osteochondral Lesions of the Talus: A Review on Talus Osteochondral Injuries, Including Osteochondritis Dissecans.
Bruns J, Habermann C, Werner M
Cartilage 2021 Dec;13(1_suppl):1380S-1401S. Epub 2021 Jan 9 doi: 10.1177/1947603520985182. PMID: 33423507Free PMC Article
Antiresorptive treatment-associated ONJ.
Eleutherakis-Papaiakovou E, Bamias A
Eur J Cancer Care (Engl) 2017 Nov;26(6) Epub 2017 Oct 24 doi: 10.1111/ecc.12787. PMID: 29063702
Osteonecrosis of the jaw and the role of macrophages.
Pazianas M
J Natl Cancer Inst 2011 Feb 2;103(3):232-40. Epub 2010 Dec 28 doi: 10.1093/jnci/djq516. PMID: 21189409
Adult osteomyelitis.
Calhoun JH, Manring MM
Infect Dis Clin North Am 2005 Dec;19(4):765-86. doi: 10.1016/j.idc.2005.07.009. PMID: 16297731

Prognosis

Conservative and Surgical Treatment of Talar Fractures: A Systematic Review and Meta-Analysis on Clinical Outcomes and Complications.
Saravi B, Lang G, Ruff R, Schmal H, Südkamp N, Ülkümen S, Zwingmann J
Int J Environ Res Public Health 2021 Aug 4;18(16) doi: 10.3390/ijerph18168274. PMID: 34444022Free PMC Article
Endocrine and bone metabolic complications in chronic liver disease and after liver transplantation in children.
Högler W, Baumann U, Kelly D
J Pediatr Gastroenterol Nutr 2012 Mar;54(3):313-21. doi: 10.1097/MPG.0b013e31823e9412. PMID: 22064631
Growth and bone health in chronic liver disease and following liver transplantation in children.
Högler W, Baumann U, Kelly D
Pediatr Endocrinol Rev 2010 Mar-Apr;7(3):266-74. PMID: 20526240
Adult osteomyelitis.
Calhoun JH, Manring MM
Infect Dis Clin North Am 2005 Dec;19(4):765-86. doi: 10.1016/j.idc.2005.07.009. PMID: 16297731
Re-treatment after full-course radiotherapy: is it a viable option?
Stewart FA
Acta Oncol 1999;38(7):855-62. doi: 10.1080/028418699432545. PMID: 10606415

Clinical prediction guides

Risk comparison of osteonecrosis of the jaw in osteoporotic patients treated with bisphosphonates vs. denosumab: a multi-institutional retrospective cohort study in Taiwan.
Liu FC, Luk KC, Chen YC
Osteoporos Int 2023 Oct;34(10):1729-1737. Epub 2023 Jun 16 doi: 10.1007/s00198-023-06818-3. PMID: 37326685Free PMC Article
Conservative and Surgical Treatment of Talar Fractures: A Systematic Review and Meta-Analysis on Clinical Outcomes and Complications.
Saravi B, Lang G, Ruff R, Schmal H, Südkamp N, Ülkümen S, Zwingmann J
Int J Environ Res Public Health 2021 Aug 4;18(16) doi: 10.3390/ijerph18168274. PMID: 34444022Free PMC Article
Alveolar bone histological necrosis observed prior to extractions in patients, who received bone-targeting agents.
Nicolatou-Galitis O, Papadopoulou E, Vardas E, Kouri M, Galiti D, Galitis E, Alexiou KE, Tsiklakis K, Ardavanis A, Razis E, Athanasiadis I, Droufakou S, Psyrri A, Karamouzis MV, Linardou H, Daliani D, Tzanninis D, Sachanas S, Laschos K, Kyrtsonis MC, Antoniou F, Laskarakis A, Giassas S, Nikolaidi A, Rigakos G, Ntokou A, Migliorati CA, Ripamonti CI
Oral Dis 2020 Jul;26(5):955-966. Epub 2020 Mar 3 doi: 10.1111/odi.13294. PMID: 32011077
Endocrine and bone metabolic complications in chronic liver disease and after liver transplantation in children.
Högler W, Baumann U, Kelly D
J Pediatr Gastroenterol Nutr 2012 Mar;54(3):313-21. doi: 10.1097/MPG.0b013e31823e9412. PMID: 22064631
Growth and bone health in chronic liver disease and following liver transplantation in children.
Högler W, Baumann U, Kelly D
Pediatr Endocrinol Rev 2010 Mar-Apr;7(3):266-74. PMID: 20526240

Recent systematic reviews

Influence of the use of bisphosphonates on the development of postextraction sequelae: Scoping review with mapping evidence of in vivo studies.
Dias MO, Menezes GPR, Tavares FOM, Leite KLF, Tenorio JDR, Esteves JC, Prado R, Maia LC
J Dent 2024 Sep;148:105051. Epub 2024 May 18 doi: 10.1016/j.jdent.2024.105051. PMID: 38763386
Does Diabetes Mellitus Increase the Risk of Avascular Osteonecrosis? A Systematic Review and Meta-Analysis.
Konarski W, Poboży T, Kotela A, Śliwczyński A, Kotela I, Hordowicz M, Krakowiak J
Int J Environ Res Public Health 2022 Nov 18;19(22) doi: 10.3390/ijerph192215219. PMID: 36429946Free PMC Article
Effects of Therapeutic Ultrasound on Growth Plates: A Systematic Review.
Baghdadi S, Harwood K, Greenberg E, Baldwin KD, Lawrence JTR
Pediatr Phys Ther 2022 Jan 1;34(1):2-8. doi: 10.1097/PEP.0000000000000846. PMID: 34958326
Conservative and Surgical Treatment of Talar Fractures: A Systematic Review and Meta-Analysis on Clinical Outcomes and Complications.
Saravi B, Lang G, Ruff R, Schmal H, Südkamp N, Ülkümen S, Zwingmann J
Int J Environ Res Public Health 2021 Aug 4;18(16) doi: 10.3390/ijerph18168274. PMID: 34444022Free PMC Article
The Utility of Conservative Treatment Modalities in the Management of Osteonecrosis.
Osmani F, Thakkar S, Vigdorchik J
Bull Hosp Jt Dis (2013) 2017 May;75(3):186-192. PMID: 28902603

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