Musculoskeletal system disorder

MedGen UID:: 6471
•Concept ID:: C0026857
•: Disease or Syndrome

Synonym:	Musculoskeletal system disease
SNOMED CT:	Musculoskeletal disorder (928000); Disorder of musculoskeletal system (928000)

Monarch Initiative:	MONDO:0002081

Definition

A non-neoplastic or neoplastic disorder that affects muscles and bones. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMusculoskeletal system disorder

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Connective and Soft Tissue Disorder
        Musculoskeletal system disorder
        Abnormality of the hand
        Abnormal hand morphology
        Abnormal carpal morphology
        Abnormal hand bone ossification
        Abnormal hand cortical bone morphology
        Abnormal hand epiphysis morphology
        Autoamputation of digits
        Curved fingers
        Deviation of the hand or of fingers of the hand
        Fractured manual digit
        Hand clenching
        Large hands
        Mitten deformity
        Notched hand bones
        Overlapping fingers
        Overmodelled hand bones
        Pointed hand bones
        Short tubular bones of the hand
        Ulnar claw
        Undermodelled hand bones
        Valgus hand deformity
        Abnormal palm morphology
        Abnormal skin morphology of the palm
        Broad palm
        Long palm
        Narrow palm
        Palmar neurofibroma
        Short palm
        Congenital deformity of hand
        Arthropathy
        Ankylosis
        Ankylosis of feet small joints
        Axial spondyloarthritis
        Elbow ankylosis
        Arthralgia
        Arthralgia/arthritis
        Shoulder pain
        Arthritis
        Aggravated Arthritis
        Allergic arthritis
        Atrophic Arthritis
        Cervical osteoarthritis
        Chondrocalcinosis
        Climacteric arthritis
        Destructive Arthritis
        Early Inflammatory Arthritis
        Enteropathic arthritis
        Gout
        Hemophilic arthropathy
        Infective arthritis
        Inflammation of sacroiliac joint
        Inflammatory spondylopathy
        Juvenile idiopathic arthritis
        Lyme arthritis
        Migratory arthritis
        Nonerosive Arthritis
        Oligoarthritis
        Osteoarthritis
        Periarthritis
        Polyarticular arthritis
        Post-streptococcal reactive arthritis
        Pseudogout
        Psoriatic arthritis
        Reactive arthritis
        Rheumatic Fever
        Rheumatoid arthritis
        Sterile arthritis
        Suppurative arthritis
        Symmetric polyarthritis
        Temporomandibular arthritis
        Arthrogryposis
        Congenital contractural arachnodactyly
        Freeman-Sheldon syndrome
        Behcet syndrome arthropathy
        Bursitis
        Crystal arthropathy
        Rotator cuff tear arthropathy
        Femoroacetabular impingement
        Hallux rigidus
        Hydrarthrosis
        Instability of joint
        Joint dislocation
        Diastasis of bone
        Diastasis of muscle
        Hip dislocation
        Joint subluxation
        Knee dislocation
        Large joint dislocations
        Lower extremity joint dislocation
        Multiple joint dislocation
        Patellar dislocation
        Pathological dislocation of joint
        Recurrent joint dislocation
        Shoulder dislocation
        Upper extremity joint dislocation
        Joint hemorrhage
        Loose body in joint
        Metatarsalgia
        Morton neuroma
        Muscle contracture
        Contracture of palmar fascia
        Contractures, Hip
        Plantar fibromatosis
        Volkmann contracture
        Nail-patella syndrome
        Neuropathic arthropathy
        Pachydermoperiostosis syndrome
        Hypertrophic osteoarthropathy, primary, autosomal recessive, 1
        Patellofemoral pain syndrome
        Polyarticular arthropathy
        Secondary hypertrophic osteoarthropathy
        Shoulder impingement syndrome
        Synovial chondromatosis
        Synovitis
        Acute Synovitis
        Tenosynovial giant cell tumor
        Temporomandibular joint disorder
        Temporomandibular joint dysfunction syndrome
        Transient arthropathy
        Cartilage disorder
        Chondromalacia of patella
        Congenital laryngomalacia
        Osteochondritis
        Osteochondritis dissecans
        Pectus carinatum
        Superior pectus carinatum
        Relapsing polychondritis
        Tietze syndrome
        Tracheobronchomalacia
        Bronchomalacia
        Cartilaginous tracheobronchomalacia
        Excessive dynamic airway collapse
        Tracheomalacia
        Congenital anomaly of musculoskeletal system
        Arterial thoracic outlet syndrome due to cervical rib
        Bone structure of L6
        Camptomelic dysplasia
        Acampomelic campomelic dysplasia
        Cervical C2/C3 vertebral fusion
        Isolated Klippel-Feil syndrome
        Klippel-Feil anomaly-myopathy-facial dysmorphism syndrome
        Klippel-Feil syndrome 1, autosomal dominant
        Klippel-Feil syndrome 2, autosomal recessive
        Klippel-Feil syndrome 3, autosomal dominant
        Congenital deformities of limbs
        Arachnodactyly
        Brachydactyly
        Congenital bowing of long bones
        Congenital deformity of lower limb
        Congenital deformity of upper limb
        Congenital vertical talus
        Ectromelia
        Polydactyly
        Proteus syndrome
        Syndactyly
        Thanatophoric dysplasia
        Congenital pectus excavatum
        Craniofacial Abnormalities
        22q11 Deletion Syndrome
        Cleidocranial dysostosis
        Costello syndrome
        Craniofacial dysostosis
        Craniosynostosis syndrome
        Holoprosencephaly sequence
        Isolated congenital microcephaly
        Leprechaunism syndrome
        Loeys-Dietz syndrome
        Maxillofacial Abnormalities
        Megalencephaly
        Noonan syndrome
        Noonan syndrome with multiple lentigines
        Orofaciodigital syndrome
        Plagiocephaly
        Platybasia
        Rubinstein-Taybi syndrome
        Russell-Silver syndrome
        Developmental Hip Dysplasia
        Hip dysplasia
        Gastroschisis
        Hajdu-Cheney syndrome
        Synostosis
        Antley-Bixler Syndrome Phenotype
        Tarsal synostosis
        Deformity of foot
        Congenital deformity of foot
        Talipes
        Hallux valgus
        Congenital hallux valgus
        Hallux varus
        Hammer Toe Syndrome
        Metatarsus adductus
        Metatarsus valgus
        Disorder of bone
        Bone cyst
        Aneurysmal bone cyst
        Cystic angiomatosis of bone
        Multiple bony cystic lesions
        Unicameral bone cyst
        Bone development disease
        Disappearing bone disease
        Dysostosis
        Gigantism
        Gorlin syndrome
        Hypoplasia of the odontoid process
        Lower limb asymmetry
        Marfan syndrome
        Osteochondrodysplasia
        Osteolytic defects of the phalanges of the hand
        Severe short stature
        Bone Diseases, Endocrine
        Acromegaly
        Congenital hypothyroidism
        Osteitis fibrosa
        Pituitary dwarfism
        Bone Diseases, Infectious
        Osteomyelitis
        Periostitis
        Skeletal tuberculosis
        Spondylitis
        Bone inflammation disease
        Bone Malalignment
        Bone Anteversion
        Bone Retroversion
        Bone necrosis
        Aseptic Necrosis of Bone
        Avascular necrosis
        Bisphosphonate-Associated Osteonecrosis
        Coxa plana
        Femur Head Necrosis
        Idiopathic phalangeal acro-osteolysis
        Mueller-weiss syndrome
        Osteonecrosis of jaw caused by bisphosphonate
        Osteonecrosis of the jaw
        Osteoradionecrosis
        Osteoradionecrosis of the mandible
        Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans
        Bone Neoplasm
        Adamantinoma
        Bone benign neoplasm
        Bone cancer
        Bone Erdheim-Chester Disease
        Bone Glomus Tumor
        Bone Langerhans Cell Histiocytosis
        Intermediate Bone Neoplasm
        Maxillofacial Neoplasm
        Neoplasm of femur
        Notochordal tumor
        Osteoclastic Giant Cell-Rich Tumor of Bone
        Skull neoplasm
        Spinal Neoplasm
        Vascular bone neoplasm
        Bone Paget disease
        Hyperphosphatasemia with bone disease
        Sternal Paget Disease
        Bone resorption disease
        Ainhum
        Alveolar bone loss
        Osteolysis
        Coxa magna
        Coxa valga
        Bilateral coxa valga
        Eosinophilic granuloma
        Epiphysiolysis
        Proximal femoral epiphysiolysis
        Genu valgum
        Genu varum
        Wind-swept deformity of the knees
        Hyperostosis
        Cranial hyperostosis
        Craniodiaphyseal dysplasia
        Craniotubular Hyperostosis
        Diffuse idiopathic skeletal hyperostosis
        Exostoses
        Hyperostosis interna frontalis
        Hyperostosis, Sternocostoclavicular
        Hyperphosphatasemia tarda
        Increased skull ossification
        Infantile cortical hyperostosis
        Vertebral hyperostosis
        Metabolic bone disorder
        Bone Demineralization, Pathologic
        Mucolipidosis
        Osteomalacia
        Osteoporosis
        Pseudohypoparathyroidism
        Rickets
        Osteochondrosis
        Familial osteoarthropathy of the fingers
        Freiberg disease
        Juvenile osteochondritis
        Juvenile osteochondrosis of spine
        Legg-Calve-Perthes disease
        Medial condensing osteitis of the clavicle
        Morbus Kienboeck
        Morbus Osgood-Schlatter
        Osteochondritis of tarsal/metatarsal bone
        Osteochondrosis of Spine
        Panner disease
        Sinding-Larsen-Johansson disease
        Vertebral column disorder
        Barre-Lieou syndrome
        Curvature of spine
        Displacement of intervertebral disc
        Intervertebral disk degeneration
        Ossification of posterior longitudinal ligament
        Osteophytosis, Spinal
        Spondylosis
        Disorder of foot
        Dysfunction of posterior tibial tendon
        Foot Dermatoses
        Tinea pedis
        Heel spur
        Plantar fasciitis
        Ulcer of foot
        Diabetic foot
        Disorder of jaw
        Disorder of periapical tissues of tooth
        Periapical periodontitis
        Radicular cyst
        Fibrous dysplasia of jaw
        Giant cell granuloma
        Giant cell epulis
        Giant cell reparative granuloma
        Jaw Abnormalities
        Congenital prognathism
        Isolated Pierre-Robin syndrome
        Micrognathia
        Retrognathias
        Jaw neoplasm
        Maxillary neoplasm
        Neoplasm of mandible
        Palate neoplasm
        Jaw, Edentulous
        Jaw, Edentulous, Partially
        Mandibular Diseases
        Craniomandibular Disorder
        Maxillary Diseases
        Fasciitis
        Fasciitis with eosinophilia syndrome
        Ischemic fasciitis
        Necrotizing fasciitis
        Musculoskeletal Neoplasm
        Musculoskeletal system benign neoplasm
        Benign muscle neoplasm
        Musculoskeletal system cancer
        Muscle cancer
        Myomatous neoplasm
        Skeletal muscle neoplasm
        Smooth muscle tumor
        Myopathy
        Actin accumulation myopathy
        Atrophic muscular disease
        Muscular dystrophy
        Post poliomyelitis syndrome
        Bethlem myopathy
        Bethlem myopathy 2
        Bethlem myopathy 1A
        Bethlem myopathy 1B
        Bethlem myopathy 1C
        Compartment syndrome
        Anterior compartment of tibia syndrome
        Chronic Exertional Compartment Syndrome
        Intra-Abdominal Hypertension
        Congenital multicore myopathy with external ophthalmoplegia
        Type 1 and type 2 muscle fiber minicore regions
        Congenital myopathy 23
        Congenital myopathy with fiber type disproportion
        Congenital structural myopathy
        Autosomal dominant centronuclear myopathy
        Central core myopathy
        Inborn mitochondrial myopathy
        Nemaline myopathy
        Severe X-linked myotubular myopathy
        Cramp
        Abdominal cramps
        Cramp in limb
        Tetany
        Critical illness myopathy
        Dermatomyositis
        Adult dermatomyositis
        Childhood type dermatomyositis
        Eosinophilia myalgia syndrome
        Familial periodic paralysis
        Andersen Tawil syndrome
        Familial hyperkalemic periodic paralysis
        Hyperkalemic periodic paralysis
        Hypokalemic periodic paralysis
        Periodic paralysis with later-onset distal motor neuropathy
        Periodic paralysis with transient compartment-like syndrome
        Fibromyalgia
        Juvenile Primary Fibromyalgia Syndrome
        GNE myopathy
        Idiopathic inflammatory myopathy
        Inflammatory myopathy
        Isaac syndrome
        Metabolic myopathy
        Glycogen storage disease, type II
        Hereditary myopathy with lactic acidosis due to ISCU deficiency
        Metabolic myopathy due to lactate transporter defect
        Muscle AMP deaminase deficiency
        Muscle weakness
        Abdominal wall muscle weakness
        Ankle weakness
        Axial muscle weakness
        Cold paresis
        Diaphragmatic weakness
        Distal muscle weakness
        Eye Muscle Weakness
        Generalized muscle weakness
        Lower limb muscle weakness
        Muscle flaccidity
        Muscle Weakness Left-Sided
        Muscle Weakness Right-Sided
        Neck muscle weakness
        Pelvic Floor Muscle Weakness
        Poor head control
        Progressive muscle weakness
        Proximal muscle weakness
        Scapuloperoneal weakness
        Truncal muscle weakness
        Upper limb muscle weakness
        Weakness of facial musculature
        Musculoskeletal pain
        Myalgia
        Pelvic girdle pain
        Myalgic encephalomeyelitis/chronic fatigue syndrome
        Myofascial pain syndrome
        Myofibrillar myopathy
        Autosomal dominant distal axonal motor neuropathy-myofibrillar myopathy syndrome
        Desmin-related myofibrillar myopathy
        Kyphosis-lateral tongue atrophy-myofibrillar myopathy syndrome
        Myofibrillar myopathy 2
        Myofibrillar myopathy 3
        Myofibrillar myopathy 4
        Myofibrillar myopathy 5
        Myofibrillar myopathy 6
        Myopathy Secondary to Fatty Acid Oxidation Disorder
        Myopathy Secondary to Glycogen Storage Disorder
        Myositis disease
        Idiopathic granulomatous myositis
        Inclusion body myositis
        Infectious myositis
        Myositis fibrosa
        Myositis ossificans
        Orbital myositis
        Polymyositis
        Pyomyositis
        Myotonic syndrome
        Batten-Turner congenital myopathy
        Myotonic dystrophy
        Non dystrophic myotonia
        Paramyotonia congenita of Von Eulenburg
        Necrotizing myopathy
        Nemaline myopathy 2
        Nemaline myopathy 8
        Polymyalgia rheumatica
        Rhabdomyolysis
        Acute rhabdomyolysis
        Alcohol-induced rhabdomyolysis
        Anesthetic-induced rhabdomylosis
        Exercise-induced rhabdomyolysis
        Hereditary myoglobinuria
        Viral infection-induced rhabdomyolysis
        Rigidity
        Cogwheel rigidity
        Decerebrate rigidity
        Decorticate rigidity
        Skeletal myopathy
        Spasticity
        Appendicular spasticity
        Opisthotonus
        Progressive spasticity
        Spasticity of facial muscles
        Spasticity of pharyngeal muscles
        Spinal muscular atrophy
        Acute infantile spinal muscular atrophy
        Kennedy disease
        Kugelberg-Welander disease
        Progressive spinal muscular atrophy
        Proximal Hereditary Motor Neuropathy Type I
        Proximal spinal muscular atrophy
        Spinal Muscular Atrophy of Childhood
        Spinal muscular atrophy, segmental
        Spinal muscular atrophy, type II
        Spinal muscular atrophy, type IV
        Werdnig-Hoffmann disease
        Steroid-induced myopathy
        Tendinopathies
        Elbow Tendinopathies
        Enthesopathy
        Stenosing tenosynovitis
        Tenosynovitis
        Toxic myopathy
        Non-Neoplastic Musculoskeletal Disorder
        Non-Neoplastic Bone Disorder
        Achondroplasia
        Bone Infarction
        Bone Rosai-Dorfman-Destombes Disease
        Cartilage development disorder
        Congenital deformity of hip joint
        Congenital pseudoarthrosis of the tibia
        Deformity of spine
        Enthesitis
        Infection of bone
        Osteogenesis imperfecta
        Osteopetrosis
        Osteopoikilosis
        Spinal Degenerative Disorder
        Spondylolisthesis
        Spondylolysis
        Tibia vara
        Non-Neoplastic Muscle Disorder
        Myocardial disorder
        Myokymia
        Rheumatism

Professional guidelines

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Brophy RH, Fillingham YA
J Am Acad Orthop Surg 2022 May 1;30(9):e721-e729. doi: 10.5435/JAAOS-D-21-01233. PMID: 35383651

Management of osteoporosis in postmenopausal women: the 2021 position statement of The North American Menopause Society.

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Clinical assessment of acute lateral ankle sprain injuries (ROAST): 2019 consensus statement and recommendations of the International Ankle Consortium.

Delahunt E, Bleakley CM, Bossard DS, Caulfield BM, Docherty CL, Doherty C, Fourchet F, Fong DT, Hertel J, Hiller CE, Kaminski TW, McKeon PO, Refshauge KM, Remus A, Verhagen E, Vicenzino BT, Wikstrom EA, Gribble PA
Br J Sports Med 2018 Oct;52(20):1304-1310. Epub 2018 Jun 9 doi: 10.1136/bjsports-2017-098885. PMID: 29886432

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Musculoskeletal system disorder

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