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T-cell leukemia

MedGen UID:
6064
•Concept ID:
C0023492
•
Neoplastic Process
Synonyms: Leukemia, Lymphocytic, T Cell; Leukemia, Lymphocytic, T-Cell; Leukemia, T Cell; Leukemia, T Lymphocytic; Leukemia, T-Cell; Leukemia, T-Cell Lymphocytic; Leukemia, T-Lymphocytic; Leukemias, T Lymphocytic; Leukemias, T-Cell; Leukemias, T-Cell Lymphocytic; Leukemias, T-Lymphocytic; Lymphocytic Leukemia, T; Lymphocytic Leukemia, T Cell; Lymphocytic Leukemia, T-Cell; Lymphocytic Leukemias, T; Lymphocytic Leukemias, T-Cell; T Cell Leukemia; T Lymphocytic Leukemia; T Lymphocytic Leukemias; T-Cell Leukemia; T-Cell Leukemias; T-Cell Lymphocytic Leukemia; T-Cell Lymphocytic Leukemias; T-Lymphocytic Leukemia; T-Lymphocytic Leukemias
 
Monarch Initiative: MONDO:0005525

Definition

A malignant disease of the T-lymphocytes in the bone marrow, thymus, and/or blood. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT-cell leukemia

Professional guidelines

PubMed

T-Cell Prolymphocytic Leukemia: Diagnosis, Pathogenesis, and Treatment.
Gutierrez M, Bladek P, Goksu B, Murga-Zamalloa C, Bixby D, Wilcox R
Int J Mol Sci 2023 Jul 28;24(15) doi: 10.3390/ijms241512106. PMID: 37569479Free PMC Article
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
LGL leukemia: from pathogenesis to treatment.
Lamy T, Moignet A, Loughran TP Jr
Blood 2017 Mar 2;129(9):1082-1094. Epub 2017 Jan 23 doi: 10.1182/blood-2016-08-692590. PMID: 28115367

Recent clinical studies

Therapy

TRBC1-targeting antibody-drug conjugates for the treatment of T cell cancers.
Nichakawade TD, Ge J, Mog BJ, Lee BS, Pearlman AH, Hwang MS, DiNapoli SR, Wyhs N, Marcou N, Glavaris S, Konig MF, Gabelli SB, Watson E, Sterling C, Wagner-Johnston N, Rozati S, Swinnen L, Fuchs E, Pardoll DM, Gabrielson K, Papadopoulos N, Bettegowda C, Kinzler KW, Zhou S, Sur S, Vogelstein B, Paul S
Nature 2024 Apr;628(8007):416-423. Epub 2024 Mar 27 doi: 10.1038/s41586-024-07233-2. PMID: 38538786Free PMC Article
Development of constitutively synergistic nanoformulations to enhance chemosensitivity in T-cell leukemia.
Kelvin JM, Chimenti ML, Zhang DY, Williams EK, Moore SG, Humber GM, Baxter TA, Birnbaum LA, Qui M, Zecca H, Thapa A, Jain J, Jui NT, Wang X, Fu H, Du Y, Kemp ML, Lam WA, Graham DK, DeRyckere D, Dreaden EC
J Control Release 2023 Sep;361:470-482. Epub 2023 Aug 14 doi: 10.1016/j.jconrel.2023.07.045. PMID: 37543290Free PMC Article
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.
Maciocia PM, Wawrzyniecka PA, Philip B, Ricciardelli I, Akarca AU, Onuoha SC, Legut M, Cole DK, Sewell AK, Gritti G, Somja J, Piris MA, Peggs KS, Linch DC, Marafioti T, Pule MA
Nat Med 2017 Dec;23(12):1416-1423. Epub 2017 Nov 13 doi: 10.1038/nm.4444. PMID: 29131157
Prolymphocytic leukemia.
Absi A, Hsi E, Kalaycio M
Curr Treat Options Oncol 2005 May;6(3):197-208. doi: 10.1007/s11864-005-0003-4. PMID: 15869731
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Prognosis

Human T-cell Leukemia Virus Type 1 (HTLV-1)-induced Uveitis.
Terada Y, Miyata K, Shoji N, Mochizuki M
Ocul Immunol Inflamm 2023 Sep;31(7):1416-1424. Epub 2023 Feb 21 doi: 10.1080/09273948.2023.2175697. PMID: 36803501
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.
Maciocia PM, Wawrzyniecka PA, Philip B, Ricciardelli I, Akarca AU, Onuoha SC, Legut M, Cole DK, Sewell AK, Gritti G, Somja J, Piris MA, Peggs KS, Linch DC, Marafioti T, Pule MA
Nat Med 2017 Dec;23(12):1416-1423. Epub 2017 Nov 13 doi: 10.1038/nm.4444. PMID: 29131157
Prolymphocytic leukemia.
Absi A, Hsi E, Kalaycio M
Curr Treat Options Oncol 2005 May;6(3):197-208. doi: 10.1007/s11864-005-0003-4. PMID: 15869731
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
Leukemia cutis.
Ratnam KV, Khor CJ, Su WP
Dermatol Clin 1994 Apr;12(2):419-31. PMID: 8045053

Clinical prediction guides

Recent advances in T-cell lymphoid neoplasms.
Bigas A, Rodriguez-Sevilla JJ, Espinosa L, Gallardo F
Exp Hematol 2022 Feb;106:3-18. Epub 2021 Dec 5 doi: 10.1016/j.exphem.2021.12.191. PMID: 34879258
State-of-Art of Cellular Therapy for Acute Leukemia.
Lee JB, Vasic D, Kang H, Fang KK, Zhang L
Int J Mol Sci 2021 Apr 27;22(9) doi: 10.3390/ijms22094590. PMID: 33925571Free PMC Article
Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma.
Miles RR, Shah RK, Frazer JK
Br J Haematol 2016 May;173(4):582-96. Epub 2016 Mar 11 doi: 10.1111/bjh.14011. PMID: 26969846Free PMC Article
Notch and Ikaros: not only converging players in T cell leukemia.
Bellavia D, Mecarozzi M, Campese AF, Grazioli P, Gulino A, Screpanti I
Cell Cycle 2007 Nov 15;6(22):2730-4. Epub 2007 Aug 15 doi: 10.4161/cc.6.22.4894. PMID: 18032925
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Recent systematic reviews

Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa.
Oloumbou EF, Engone-Ondo JD, Mamimandjiami Idam I, Moussavou-Boudzanga P, Mfouo-Tynga I, Mouinga-Ondeme A
Viruses 2022 Dec 16;14(12) doi: 10.3390/v14122808. PMID: 36560812Free PMC Article
The efficacy of anti-CD19 chimeric antigen receptor T cells for B-cell malignancies.
Cao JX, Gao WJ, You J, Wu LH, Liu JL, Wang ZX
Cytotherapy 2019 Jul;21(7):769-781. Epub 2019 May 31 doi: 10.1016/j.jcyt.2019.04.005. PMID: 31160157
Thyroid cancer and T lymphoblastic leukemia in Crohn disease: a case report and literature review.
Byun JM, Baek SK, Yoon HJ, Kim SY, Maeng CH, Park TS, Kim HJ, Choi YY, Um YJ
Lab Med 2015 Spring;46(2):140-5. doi: 10.1309/LMU4KMJDRM3AD6FQ. PMID: 25918193
Diseases of large granular lymphocytes.
Alekshun TJ, Sokol L
Cancer Control 2007 Apr;14(2):141-50. doi: 10.1177/107327480701400207. PMID: 17387299

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