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Epilepsy

MedGen UID:
4506
Concept ID:
C0014544
Disease or Syndrome
Synonyms: Seizure disorder; Seizure Disorders
SNOMED CT: Epilepsy (84757009); Seizure disorder (128613002)
 
Monarch Initiative: MONDO:0005027

Definition

A disease of the brain characterized by an enduring predisposition to generate epileptic seizures. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpilepsy

Professional guidelines

PubMed

Zuberi SM, Wirrell E, Yozawitz E, Wilmshurst JM, Specchio N, Riney K, Pressler R, Auvin S, Samia P, Hirsch E, Galicchio S, Triki C, Snead OC, Wiebe S, Cross JH, Tinuper P, Scheffer IE, Perucca E, Moshé SL, Nabbout R
Epilepsia 2022 Jun;63(6):1349-1397. Epub 2022 May 3 doi: 10.1111/epi.17239. PMID: 35503712
Uy CE, Binks S, Irani SR
Pract Neurol 2021 Oct;21(5):412-423. Epub 2021 Jun 9 doi: 10.1136/practneurol-2020-002567. PMID: 34108243Free PMC Article
van Wegberg AMJ, MacDonald A, Ahring K, Bélanger-Quintana A, Blau N, Bosch AM, Burlina A, Campistol J, Feillet F, Giżewska M, Huijbregts SC, Kearney S, Leuzzi V, Maillot F, Muntau AC, van Rijn M, Trefz F, Walter JH, van Spronsen FJ
Orphanet J Rare Dis 2017 Oct 12;12(1):162. doi: 10.1186/s13023-017-0685-2. PMID: 29025426Free PMC Article

Curated

UK NICE Guideline NG217, Epilepsies in children, young people and adults, 2022

Recent clinical studies

Etiology

Perucca P, Bahlo M, Berkovic SF
Annu Rev Genomics Hum Genet 2020 Aug 31;21:205-230. Epub 2020 Apr 27 doi: 10.1146/annurev-genom-120219-074937. PMID: 32339036
Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003
Baxendale S
Pract Neurol 2018 Feb;18(1):43-48. Epub 2018 Jan 11 doi: 10.1136/practneurol-2017-001827. PMID: 29326240
Maguire M, Singh J, Marson A
Pract Neurol 2018 Apr;18(2):106-114. Epub 2017 Dec 22 doi: 10.1136/practneurol-2017-001775. PMID: 29273616
Shorvon SD
Epilepsia 2011 Jun;52(6):1052-7. Epub 2011 Mar 30 doi: 10.1111/j.1528-1167.2011.03041.x. PMID: 21449936

Diagnosis

Katyayan A, Diaz-Medina G
Neurol Clin 2021 Aug;39(3):779-795. doi: 10.1016/j.ncl.2021.04.002. PMID: 34215386
Neubauer BA
Neuropediatrics 2021 Apr;52(2):71-72. Epub 2021 Mar 19 doi: 10.1055/s-0041-1726339. PMID: 33742431
Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003
Baxendale S
Pract Neurol 2018 Feb;18(1):43-48. Epub 2018 Jan 11 doi: 10.1136/practneurol-2017-001827. PMID: 29326240
Abramovici S, Bagić A
Handb Clin Neurol 2016;138:159-71. doi: 10.1016/B978-0-12-802973-2.00010-0. PMID: 27637958

Therapy

Perucca E, White HS, Bialer M
CNS Drugs 2023 Sep;37(9):781-795. Epub 2023 Aug 21 doi: 10.1007/s40263-023-01025-4. PMID: 37603261Free PMC Article
Billakota S, Devinsky O, Marsh E
Curr Opin Neurol 2019 Apr;32(2):220-226. doi: 10.1097/WCO.0000000000000660. PMID: 30676535
Trinka E, Kälviäinen R
Seizure 2017 Jan;44:65-73. Epub 2016 Nov 14 doi: 10.1016/j.seizure.2016.11.001. PMID: 27890484
Gloss D, Vickrey B
Cochrane Database Syst Rev 2014 Mar 5;2014(3):CD009270. doi: 10.1002/14651858.CD009270.pub3. PMID: 24595491Free PMC Article
Glauser T, Ben-Menachem E, Bourgeois B, Cnaan A, Guerreiro C, Kälviäinen R, Mattson R, French JA, Perucca E, Tomson T; ILAE Subcommission on AED Guidelines
Epilepsia 2013 Mar;54(3):551-63. Epub 2013 Jan 25 doi: 10.1111/epi.12074. PMID: 23350722

Prognosis

Friedman D
Curr Opin Neurol 2022 Apr 1;35(2):181-188. doi: 10.1097/WCO.0000000000001034. PMID: 35102124Free PMC Article
GBD 2016 Neurology Collaborators
Lancet Neurol 2019 May;18(5):459-480. Epub 2019 Mar 14 doi: 10.1016/S1474-4422(18)30499-X. PMID: 30879893Free PMC Article
Kalilani L, Sun X, Pelgrims B, Noack-Rink M, Villanueva V
Epilepsia 2018 Dec;59(12):2179-2193. Epub 2018 Nov 13 doi: 10.1111/epi.14596. PMID: 30426482
Fiest KM, Sauro KM, Wiebe S, Patten SB, Kwon CS, Dykeman J, Pringsheim T, Lorenzetti DL, Jetté N
Neurology 2017 Jan 17;88(3):296-303. Epub 2016 Dec 16 doi: 10.1212/WNL.0000000000003509. PMID: 27986877Free PMC Article
Abramovici S, Bagić A
Handb Clin Neurol 2016;138:159-71. doi: 10.1016/B978-0-12-802973-2.00010-0. PMID: 27637958

Clinical prediction guides

Baud MO, Proix T, Rao VR, Schindler K
Curr Opin Neurol 2020 Apr;33(2):163-172. doi: 10.1097/WCO.0000000000000798. PMID: 32049738
Donos C, Maliia MD, Dümpelmann M, Schulze-Bonhage A
Epilepsia 2018 Mar;59(3):650-660. Epub 2018 Jan 11 doi: 10.1111/epi.13997. PMID: 29322500
Wirrell EC
Epilepsia 2013 May;54 Suppl 2:19-22. doi: 10.1111/epi.12179. PMID: 23646966
Sheldon R
Prog Cardiovasc Dis 2013 Jan-Feb;55(4):390-5. doi: 10.1016/j.pcad.2012.10.011. PMID: 23472776
Litt B, Echauz J
Lancet Neurol 2002 May;1(1):22-30. doi: 10.1016/s1474-4422(02)00003-0. PMID: 12849542

Recent systematic reviews

Duñabeitia I, Bidaurrazaga-Letona I, Diz JC, Colon-Leira S, García-Fresneda A, Ayán C
Epilepsy Behav 2022 Dec;137(Pt A):108959. Epub 2022 Nov 15 doi: 10.1016/j.yebeh.2022.108959. PMID: 36399947
Sheidley BR, Malinowski J, Bergner AL, Bier L, Gloss DS, Mu W, Mulhern MM, Partack EJ, Poduri A
Epilepsia 2022 Feb;63(2):375-387. Epub 2021 Dec 10 doi: 10.1111/epi.17141. PMID: 34893972
Jafarpour S, Hirsch LJ, Gaínza-Lein M, Kellinghaus C, Detyniecki K
Seizure 2019 May;68:9-15. Epub 2018 May 21 doi: 10.1016/j.seizure.2018.05.013. PMID: 29871784
Kalilani L, Sun X, Pelgrims B, Noack-Rink M, Villanueva V
Epilepsia 2018 Dec;59(12):2179-2193. Epub 2018 Nov 13 doi: 10.1111/epi.14596. PMID: 30426482
Maguire M, Marson AG, Ramaratnam S
BMJ Clin Evid 2011 May 6;2011 PMID: 21549021Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG217, Epilepsies in children, young people and adults, 2022

    Consumer resources

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