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Epilepsy

MedGen UID:
4506
•Concept ID:
C0014544
•
Disease or Syndrome
Synonyms: Seizure disorder; Seizure Disorders
SNOMED CT: Epilepsy (84757009); Seizure disorder (128613002)
 
Monarch Initiative: MONDO:0005027

Definition

A disease of the brain characterized by an enduring predisposition to generate epileptic seizures. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpilepsy

Professional guidelines

PubMed

Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures.
Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702
ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions.
Zuberi SM, Wirrell E, Yozawitz E, Wilmshurst JM, Specchio N, Riney K, Pressler R, Auvin S, Samia P, Hirsch E, Galicchio S, Triki C, Snead OC, Wiebe S, Cross JH, Tinuper P, Scheffer IE, Perucca E, Moshé SL, Nabbout R
Epilepsia 2022 Jun;63(6):1349-1397. Epub 2022 May 3 doi: 10.1111/epi.17239. PMID: 35503712
Autoimmune encephalitis: clinical spectrum and management.
Uy CE, Binks S, Irani SR
Pract Neurol 2021 Oct;21(5):412-423. Epub 2021 Jun 9 doi: 10.1136/practneurol-2020-002567. PMID: 34108243Free PMC Article

Curated

UK NICE Guideline NG217, Epilepsies in children, young people and adults, 2022

Recent clinical studies

Etiology

The Genetics of Epilepsy.
Perucca P, Bahlo M, Berkovic SF
Annu Rev Genomics Hum Genet 2020 Aug 31;21:205-230. Epub 2020 Apr 27 doi: 10.1146/annurev-genom-120219-074937. PMID: 32339036
The Epidemiology of Epilepsy.
Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003
ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology.
Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, Hirsch E, Jain S, Mathern GW, Moshé SL, Nordli DR, Perucca E, Tomson T, Wiebe S, Zhang YH, Zuberi SM
Epilepsia 2017 Apr;58(4):512-521. Epub 2017 Mar 8 doi: 10.1111/epi.13709. PMID: 28276062Free PMC Article
The natural history and prognosis of epilepsy.
Beghi E, Giussani G, Sander JW
Epileptic Disord 2015 Sep;17(3):243-53. doi: 10.1684/epd.2015.0751. PMID: 26234761
The etiologic classification of epilepsy.
Shorvon SD
Epilepsia 2011 Jun;52(6):1052-7. Epub 2011 Mar 30 doi: 10.1111/j.1528-1167.2011.03041.x. PMID: 21449936

Diagnosis

Wearable Digital Health Technology for Epilepsy.
Donner E, Devinsky O, Friedman D
N Engl J Med 2024 Feb 22;390(8):736-745. doi: 10.1056/NEJMra2301913. PMID: 38381676
Epilepsy: Epileptic Syndromes and Treatment.
Katyayan A, Diaz-Medina G
Neurol Clin 2021 Aug;39(3):779-795. doi: 10.1016/j.ncl.2021.04.002. PMID: 34215386
Epilepsy in Neuropediatrics.
Neubauer BA
Neuropediatrics 2021 Apr;52(2):71-72. Epub 2021 Mar 19 doi: 10.1055/s-0041-1726339. PMID: 33742431
The Epidemiology of Epilepsy.
Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003
Neuropsychological assessment in epilepsy.
Baxendale S
Pract Neurol 2018 Feb;18(1):43-48. Epub 2018 Jan 11 doi: 10.1136/practneurol-2017-001827. PMID: 29326240

Therapy

New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: II. Treatments in Clinical Development.
Perucca E, White HS, Bialer M
CNS Drugs 2023 Sep;37(9):781-795. Epub 2023 Aug 21 doi: 10.1007/s40263-023-01025-4. PMID: 37603261Free PMC Article
Diagnosing nonconvulsive status epilepticus: Defining electroencephalographic and clinical response to diagnostic intravenous antiseizure medication trials.
Leitinger M, Gaspard N, Hirsch LJ, Beniczky S, Kaplan PW, Husari K, Trinka E
Epilepsia 2023 Sep;64(9):2351-2360. Epub 2023 Jul 10 doi: 10.1111/epi.17694. PMID: 37350392
Placebo in epilepsy.
Goldenholz DM, Goldenholz SR
Int Rev Neurobiol 2020;153:231-266. Epub 2020 Jun 9 doi: 10.1016/bs.irn.2020.03.033. PMID: 32563290
25 years of advances in the definition, classification and treatment of status epilepticus.
Trinka E, Kälviäinen R
Seizure 2017 Jan;44:65-73. Epub 2016 Nov 14 doi: 10.1016/j.seizure.2016.11.001. PMID: 27890484
Epilepsy biomarkers.
Engel J Jr, Pitkänen A, Loeb JA, Dudek FE, Bertram EH 3rd, Cole AJ, Moshé SL, Wiebe S, Jensen FE, Mody I, Nehlig A, Vezzani A
Epilepsia 2013 Aug;54 Suppl 4(0 4):61-9. doi: 10.1111/epi.12299. PMID: 23909854Free PMC Article

Prognosis

Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
GBD 2016 Neurology Collaborators
Lancet Neurol 2019 May;18(5):459-480. Epub 2019 Mar 14 doi: 10.1016/S1474-4422(18)30499-X. PMID: 30879893Free PMC Article
The epidemiology of drug-resistant epilepsy: A systematic review and meta-analysis.
Kalilani L, Sun X, Pelgrims B, Noack-Rink M, Villanueva V
Epilepsia 2018 Dec;59(12):2179-2193. Epub 2018 Nov 13 doi: 10.1111/epi.14596. PMID: 30426482
Practice guideline summary: Sudden unexpected death in epilepsy incidence rates and risk factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society.
Harden C, Tomson T, Gloss D, Buchhalter J, Cross JH, Donner E, French JA, Gil-Nagel A, Hesdorffer DC, Smithson WH, Spitz MC, Walczak TS, Sander JW, Ryvlin P
Neurology 2017 Apr 25;88(17):1674-1680. doi: 10.1212/WNL.0000000000003685. PMID: 28438841
Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies.
Fiest KM, Sauro KM, Wiebe S, Patten SB, Kwon CS, Dykeman J, Pringsheim T, Lorenzetti DL, Jetté N
Neurology 2017 Jan 17;88(3):296-303. Epub 2016 Dec 16 doi: 10.1212/WNL.0000000000003509. PMID: 27986877Free PMC Article
Epidemiology of epilepsy.
Abramovici S, Bagić A
Handb Clin Neurol 2016;138:159-71. doi: 10.1016/B978-0-12-802973-2.00010-0. PMID: 27637958

Clinical prediction guides

Chance and risk in epilepsy.
Baud MO, Proix T, Rao VR, Schindler K
Curr Opin Neurol 2020 Apr;33(2):163-172. doi: 10.1097/WCO.0000000000000798. PMID: 32049738
Seizure prediction and intervention.
Meisel C, Loddenkemper T
Neuropharmacology 2020 Aug 1;172:107898. Epub 2019 Dec 5 doi: 10.1016/j.neuropharm.2019.107898. PMID: 31839204
Predicting pharmacoresistance in pediatric epilepsy.
Wirrell EC
Epilepsia 2013 May;54 Suppl 2:19-22. doi: 10.1111/epi.12179. PMID: 23646966
Syncope diagnostic scores.
Sheldon R
Prog Cardiovasc Dis 2013 Jan-Feb;55(4):390-5. doi: 10.1016/j.pcad.2012.10.011. PMID: 23472776
Seizure prediction and its applications.
Iasemidis LD
Neurosurg Clin N Am 2011 Oct;22(4):489-506, vi. doi: 10.1016/j.nec.2011.07.004. PMID: 21939848Free PMC Article

Recent systematic reviews

Epilepsy-associated genes: an update.
Zhang MW, Liang XY, Wang J, Gao LD, Liao HJ, He YH, Yi YH, He N, Liao WP; China Epilepsy Gene 1.0 Project
Seizure 2024 Mar;116:4-13. Epub 2023 Sep 23 doi: 10.1016/j.seizure.2023.09.021. PMID: 37777370
Sleep quality and architecture in Idiopathic generalized epilepsy: A systematic review and meta-analysis.
Lehner J, Frueh JS, Datta AN
Sleep Med Rev 2022 Oct;65:101689. Epub 2022 Aug 17 doi: 10.1016/j.smrv.2022.101689. PMID: 36037570
Medical treatment of Rasmussen's Encephalitis: A systematic review.
Lagarde S, Boucraut J, Bartolomei F
Rev Neurol (Paris) 2022 Sep;178(7):675-691. Epub 2022 Feb 4 doi: 10.1016/j.neurol.2022.01.007. PMID: 35131107
Seizure cluster: Definition, prevalence, consequences, and management.
Jafarpour S, Hirsch LJ, Gaínza-Lein M, Kellinghaus C, Detyniecki K
Seizure 2019 May;68:9-15. Epub 2018 May 21 doi: 10.1016/j.seizure.2018.05.013. PMID: 29871784
Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies.
Fiest KM, Sauro KM, Wiebe S, Patten SB, Kwon CS, Dykeman J, Pringsheim T, Lorenzetti DL, Jetté N
Neurology 2017 Jan 17;88(3):296-303. Epub 2016 Dec 16 doi: 10.1212/WNL.0000000000003509. PMID: 27986877Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG217, Epilepsies in children, young people and adults, 2022

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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