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Childhood epilepsy with centrotemporal spikes

MedGen UID:: 138210
•Concept ID:: C0376532
•: Disease or Syndrome

Synonym:	Rolandic epilepsy
Modes of inheritance:	Autosomal dominant inheritance MedGen UID: 141047 •Concept ID: C0443147 • Intellectual Product Source: Orphanet A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele. Autosomal dominant inheritance (Orphanet)

Related gene: Gene(s) associated with related conditions. For conditions in a hierarchy, the parent condition will list the genes associated with the children conditions.	GRIN2A

Monarch Initiative:	MONDO:0007295
Orphanet:	ORPHA1945

Definition

Rolandic epilepsy (RE) is a focal childhood epilepsy characterized by seizures consisting of unilateral facial sensory-motor symptoms, with electroencephalogram (EEG) showing sharp biphasic waves over the rolandic region. It is an age-related epilepsy, with excellent outcome. [from ORDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVChildhood epilepsy with centrotemporal spikes
- CROGVBenign Rolandic epilepsy
- CROGVLandau-Kleffner syndrome

Disorder by Site
- Disorder of nervous system
  - Disorder of the central nervous system
    - Brain disorder
      - Epilepsy
        Epilepsy syndrome
        Childhood epilepsy with centrotemporal spikes
        Benign Rolandic epilepsy
        Landau-Kleffner syndrome

Professional guidelines

PubMed

Lacosamide monotherapy for the treatment of childhood epilepsy with centrotemporal spikes.

Okanishi T, Fujii Y, Sakuma S, Shiraishi H, Motoi H, Yazaki K, Enoki H, Fujimoto A
Brain Dev 2022 Jun;44(6):380-385. Epub 2022 Feb 28 doi: 10.1016/j.braindev.2022.02.005. PMID: 35241306

Epilepsy: Epileptic Syndromes and Treatment.

Katyayan A, Diaz-Medina G
Neurol Clin 2021 Aug;39(3):779-795. doi: 10.1016/j.ncl.2021.04.002. PMID: 34215386

Treatment of benign focal epilepsies in children: when and how should be treated?

Oguni H
Brain Dev 2011 Mar;33(3):207-12. Epub 2010 Nov 20 doi: 10.1016/j.braindev.2010.10.024. PMID: 21095081

See all (8)

Recent clinical studies

Etiology

Xu F, Xu Y, Wang Y, Niu K, Li Y, Wang P, Li Y, Sun J, Chen Q, Wang X
Clin Neurophysiol 2023 Aug;152:11-21. Epub 2023 May 18 doi: 10.1016/j.clinph.2023.05.005. PMID: 37257319

Lacosamide monotherapy for the treatment of childhood epilepsy with centrotemporal spikes.

Okanishi T, Fujii Y, Sakuma S, Shiraishi H, Motoi H, Yazaki K, Enoki H, Fujimoto A
Brain Dev 2022 Jun;44(6):380-385. Epub 2022 Feb 28 doi: 10.1016/j.braindev.2022.02.005. PMID: 35241306

Evaluation of eating behaviors in childhood epilepsy with centrotemporal spikes: Case-control study.

Coskun O, Kipoglu O, Karacabey BN, Kilic MA, Simsek Ceran D, Yildiz EP, Aydınlı N, Caliskan M
Epilepsy Behav 2021 Jul;120:108029. Epub 2021 May 13 doi: 10.1016/j.yebeh.2021.108029. PMID: 33992962

Does a normalizing electroencephalogram in benign childhood epilepsy with centrotemporal spikes abort attention deficit hyperactivity disorder?

Schneebaum-Sender N, Goldberg-Stern H, Fattal-Valevski A, Kramer U
Pediatr Neurol 2012 Oct;47(4):279-83. doi: 10.1016/j.pediatrneurol.2012.06.009. PMID: 22964442

Gabapentin.

Morris GL
Epilepsia 1999;40 Suppl 5:S63-70. doi: 10.1111/j.1528-1157.1999.tb00921.x. PMID: 10530696

See all (131)

Diagnosis

Epilepsy: Epileptic Syndromes and Treatment.

Katyayan A, Diaz-Medina G
Neurol Clin 2021 Aug;39(3):779-795. doi: 10.1016/j.ncl.2021.04.002. PMID: 34215386

Oral language in children with benign childhood epilepsy with centrotemporal spikes.

Teixeira JM, Santos ME, Oom P
Epilepsy Behav 2020 Oct;111:107328. Epub 2020 Sep 9 doi: 10.1016/j.yebeh.2020.107328. PMID: 33027869

Benign childhood epilepsy with centrotemporal spikes (BECTS) and developmental co-ordination disorder.

Kirby A, Williams N, Koelewijn L, Brindley LM, Muthukumaraswamy SD, Te Water Naudé J, Thomas M, Gibbon F, Singh KD, Hamandi K
Epilepsy Behav 2017 Jul;72:122-126. Epub 2017 Jun 7 doi: 10.1016/j.yebeh.2017.04.014. PMID: 28575760

Atypical presentations of benign childhood epilepsy with centrotemporal spikes: a review.

Kramer U
J Child Neurol 2008 Jul;23(7):785-90. doi: 10.1177/0883073808316363. PMID: 18658078

Typical semiology of benign childhood epilepsy with centrotemporal spikes (BCECTS).

Stephani U
Epileptic Disord 2000;2 Suppl 1:S3-4. PMID: 11231216

See all (108)

Therapy

Lacosamide monotherapy for the treatment of childhood epilepsy with centrotemporal spikes.

Okanishi T, Fujii Y, Sakuma S, Shiraishi H, Motoi H, Yazaki K, Enoki H, Fujimoto A
Brain Dev 2022 Jun;44(6):380-385. Epub 2022 Feb 28 doi: 10.1016/j.braindev.2022.02.005. PMID: 35241306

Comparative assessment of health-related quality of life with and without anticonvulsant therapy in patients with childhood epilepsy with centrotemporal spikes.

An O, Nagae LM, Aringazina A, Winesett SP
J Int Med Res 2021 Aug;49(8):3000605211039805. doi: 10.1177/03000605211039805. PMID: 34459274 Free PMC Article

Cognitive and behavioral outcomes in benign childhood epilepsy with centrotemporal spikes.

Vannest J, Tenney JR, Gelineau-Morel R, Maloney T, Glauser TA
Epilepsy Behav 2015 Apr;45:85-91. Epub 2015 Mar 13 doi: 10.1016/j.yebeh.2015.01.041. PMID: 25775975

Does a normalizing electroencephalogram in benign childhood epilepsy with centrotemporal spikes abort attention deficit hyperactivity disorder?

Schneebaum-Sender N, Goldberg-Stern H, Fattal-Valevski A, Kramer U
Pediatr Neurol 2012 Oct;47(4):279-83. doi: 10.1016/j.pediatrneurol.2012.06.009. PMID: 22964442

Gabapentin.

Morris GL
Epilepsia 1999;40 Suppl 5:S63-70. doi: 10.1111/j.1528-1157.1999.tb00921.x. PMID: 10530696

See all (51)

Prognosis

International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions.

Specchio N, Wirrell EC, Scheffer IE, Nabbout R, Riney K, Samia P, Guerreiro M, Gwer S, Zuberi SM, Wilmshurst JM, Yozawitz E, Pressler R, Hirsch E, Wiebe S, Cross HJ, Perucca E, Moshé SL, Tinuper P, Auvin S
Epilepsia 2022 Jun;63(6):1398-1442. Epub 2022 May 3 doi: 10.1111/epi.17241. PMID: 35503717

Epilepsy: Epileptic Syndromes and Treatment.

Katyayan A, Diaz-Medina G
Neurol Clin 2021 Aug;39(3):779-795. doi: 10.1016/j.ncl.2021.04.002. PMID: 34215386

The attention networks in benign epilepsy with centrotemporal spikes: A long-term follow-up study.

Wu L, Yang X, Wang X, Yu S, Yang B
J Clin Neurosci 2021 Jun;88:22-27. Epub 2021 Mar 29 doi: 10.1016/j.jocn.2021.03.022. PMID: 33992188

Treatment of benign focal epilepsies in children: when and how should be treated?

Oguni H
Brain Dev 2011 Mar;33(3):207-12. Epub 2010 Nov 20 doi: 10.1016/j.braindev.2010.10.024. PMID: 21095081

Typical semiology of benign childhood epilepsy with centrotemporal spikes (BCECTS).

Stephani U
Epileptic Disord 2000;2 Suppl 1:S3-4. PMID: 11231216

See all (79)

Clinical prediction guides

Xu F, Xu Y, Wang Y, Niu K, Li Y, Wang P, Li Y, Sun J, Chen Q, Wang X
Clin Neurophysiol 2023 Aug;152:11-21. Epub 2023 May 18 doi: 10.1016/j.clinph.2023.05.005. PMID: 37257319

Involvement of brain structures in childhood epilepsy with centrotemporal spikes.

Ito Y, Maki Y, Okai Y, Kidokoro H, Bagarinao E, Takeuchi T, Ohno A, Nakata T, Ishihara N, Okumura A, Yamamoto H, Maesawa S, Natsume J
Pediatr Int 2022 Jan;64(1):e15001. doi: 10.1111/ped.15001. PMID: 34562291

Evaluation of eating behaviors in childhood epilepsy with centrotemporal spikes: Case-control study.

Coskun O, Kipoglu O, Karacabey BN, Kilic MA, Simsek Ceran D, Yildiz EP, Aydınlı N, Caliskan M
Epilepsy Behav 2021 Jul;120:108029. Epub 2021 May 13 doi: 10.1016/j.yebeh.2021.108029. PMID: 33992962

Benign epilepsy with centrotemporal spikes: Is there a thalamocortical network dysfunction present?

Şanlıdağ B, Köken ÖY, Temel EÜ, Arhan E, Aydın K, Serdaroğlu A
Seizure 2020 Jul;79:44-48. Epub 2020 May 5 doi: 10.1016/j.seizure.2020.04.003. PMID: 32416566

Does a normalizing electroencephalogram in benign childhood epilepsy with centrotemporal spikes abort attention deficit hyperactivity disorder?

Schneebaum-Sender N, Goldberg-Stern H, Fattal-Valevski A, Kramer U
Pediatr Neurol 2012 Oct;47(4):279-83. doi: 10.1016/j.pediatrneurol.2012.06.009. PMID: 22964442

See all (89)

Recent systematic reviews

Levetiracetam versus carbamazepine in treatment of rolandic epilepsy.

Asadi-Pooya AA, Forouzesh M, Eidi H, Mirzaghafour SE
Epilepsy Behav 2019 May;94:1-8. Epub 2019 Mar 15 doi: 10.1016/j.yebeh.2019.02.009. PMID: 30884401

Language skills in children with benign childhood epilepsy with centrotemporal spikes: A systematic review.

Teixeira J, Santos ME
Epilepsy Behav 2018 Jul;84:15-21. Epub 2018 May 3 doi: 10.1016/j.yebeh.2018.04.002. PMID: 29730501

See all (2)

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Childhood epilepsy with centrotemporal spikes

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

Practice guidelines

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Reviews

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