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Bone marrow disorder

MedGen UID:
2311
•Concept ID:
C0005956
•
Disease or Syndrome
Synonyms: Bone Marrow Disease; Bone Marrow Diseases; Disease, Bone Marrow; Diseases, Bone Marrow; Marrow Disease, Bone; Marrow Diseases, Bone
SNOMED CT: Bone marrow disorder (127035006)

Definition

Any disease of the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone marrow disorder

Professional guidelines

PubMed

Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management.
Rajkumar SV
Am J Hematol 2024 Sep;99(9):1802-1824. Epub 2024 Jun 28 doi: 10.1002/ajh.27422. PMID: 38943315Free PMC Article
Multiple myeloma: 2022 update on diagnosis, risk stratification, and management.
Rajkumar SV
Am J Hematol 2022 Aug;97(8):1086-1107. Epub 2022 May 23 doi: 10.1002/ajh.26590. PMID: 35560063Free PMC Article
Multiple myeloma: 2020 update on diagnosis, risk-stratification and management.
Rajkumar SV
Am J Hematol 2020 May;95(5):548-567. doi: 10.1002/ajh.25791. PMID: 32212178

Recent clinical studies

Etiology

Bone Marrow Adipose Tissue.
Marinelli Busilacchi E, Morsia E, Poloni A
Cells 2024 Apr 23;13(9) doi: 10.3390/cells13090724. PMID: 38727260Free PMC Article
Updated recommendations on the use of ruxolitinib for the treatment of myelofibrosis.
Devos T, Selleslag D, Granacher N, Havelange V, Benghiat FS
Hematology 2022 Dec;27(1):23-31. doi: 10.1080/16078454.2021.2009645. PMID: 34957926
The applications of buckminsterfullerene C60 and derivatives in orthopaedic research.
Liu Q, Cui Q, Li XJ, Jin L
Connect Tissue Res 2014 Apr;55(2):71-9. Epub 2014 Jan 24 doi: 10.3109/03008207.2013.877894. PMID: 24409811Free PMC Article
Unexplained macrocytosis.
Younes M, Dagher GA, Dulanto JV, Njeim M, Kuriakose P
South Med J 2013 Feb;106(2):121-5. doi: 10.1097/SMJ.0b013e3182824cdf. PMID: 23380746
Evaluation of anemia in children.
Janus J, Moerschel SK
Am Fam Physician 2010 Jun 15;81(12):1462-71. PMID: 20540485

Diagnosis

Updated recommendations on the use of ruxolitinib for the treatment of myelofibrosis.
Devos T, Selleslag D, Granacher N, Havelange V, Benghiat FS
Hematology 2022 Dec;27(1):23-31. doi: 10.1080/16078454.2021.2009645. PMID: 34957926
Cold agglutinin disease.
Berentsen S
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):226-231. doi: 10.1182/asheducation-2016.1.226. PMID: 27913484Free PMC Article
The clinical and laboratory evaluation of the patient with erythrocytosis.
Lee G, Arcasoy MO
Eur J Intern Med 2015 Jun;26(5):297-302. Epub 2015 Mar 31 doi: 10.1016/j.ejim.2015.03.007. PMID: 25837692
Unexplained macrocytosis.
Younes M, Dagher GA, Dulanto JV, Njeim M, Kuriakose P
South Med J 2013 Feb;106(2):121-5. doi: 10.1097/SMJ.0b013e3182824cdf. PMID: 23380746
Evaluation of anemia in children.
Janus J, Moerschel SK
Am Fam Physician 2010 Jun 15;81(12):1462-71. PMID: 20540485

Therapy

Updated recommendations on the use of ruxolitinib for the treatment of myelofibrosis.
Devos T, Selleslag D, Granacher N, Havelange V, Benghiat FS
Hematology 2022 Dec;27(1):23-31. doi: 10.1080/16078454.2021.2009645. PMID: 34957926
DNA-hypomethylating agents as epigenetic therapy before and after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndromes and juvenile myelomonocytic leukemia.
Flotho C, Sommer S, Lübbert M
Semin Cancer Biol 2018 Aug;51:68-79. Epub 2017 Nov 9 doi: 10.1016/j.semcancer.2017.10.011. PMID: 29129488
Cold agglutinin disease.
Berentsen S
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):226-231. doi: 10.1182/asheducation-2016.1.226. PMID: 27913484Free PMC Article
Evaluation of anemia in children.
Janus J, Moerschel SK
Am Fam Physician 2010 Jun 15;81(12):1462-71. PMID: 20540485
Arsenic trioxide as a treatment for myelodysplastic syndrome.
Sekeres MA
Curr Hematol Malig Rep 2006 Mar;1(1):34-8. doi: 10.1007/s11899-006-0015-6. PMID: 20425329

Prognosis

MiR-181a-2-3p as a potential diagnostic and prognostic marker for myelodysplastic syndrome.
Liang X, Shi Z, Huang X, Wan C, Zhu S, Wu M, Li Z, Tang Z, Li J, Zhao W, Luo J, Liu Z
Hematology 2022 Dec;27(1):1246-1252. doi: 10.1080/16078454.2022.2149971. PMID: 36444993
Updated recommendations on the use of ruxolitinib for the treatment of myelofibrosis.
Devos T, Selleslag D, Granacher N, Havelange V, Benghiat FS
Hematology 2022 Dec;27(1):23-31. doi: 10.1080/16078454.2021.2009645. PMID: 34957926
Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis.
Martí-Carvajal AJ, Anand V, Solà I
Cochrane Database Syst Rev 2015 Apr 10;2015(4):CD010298. doi: 10.1002/14651858.CD010298.pub2. PMID: 25860512Free PMC Article
Pediatric aplastic anemia and refractory cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors.
Forester CM, Sartain SE, Guo D, Harris MH, Weinberg OK, Fleming MD, London WB, Williams DA, Hofmann I
Am J Hematol 2015 Apr;90(4):320-6. Epub 2015 Mar 2 doi: 10.1002/ajh.23937. PMID: 25580823Free PMC Article
Unexplained macrocytosis.
Younes M, Dagher GA, Dulanto JV, Njeim M, Kuriakose P
South Med J 2013 Feb;106(2):121-5. doi: 10.1097/SMJ.0b013e3182824cdf. PMID: 23380746

Clinical prediction guides

A nomogram model for predicting the efficacy of cyclosporine in patients with pure red cell aplasia.
Yang L, Niu H, Zhang T, Cao Q, Liu M, Liu Y, Yan L, Qi W, Wang T, Liu C, Li L, Xing L, Wang H, Shao Z, Fu R
Ann Hematol 2024 Jun;103(6):1877-1885. Epub 2024 Feb 3 doi: 10.1007/s00277-024-05636-9. PMID: 38308019
Efficacy of ALK5 inhibition in myelofibrosis.
Yue L, Bartenstein M, Zhao W, Ho WT, Han Y, Murdun C, Mailloux AW, Zhang L, Wang X, Budhathoki A, Pradhan K, Rapaport F, Wang H, Shao Z, Ren X, Steidl U, Levine RL, Zhao ZJ, Verma A, Epling-Burnette PK
JCI Insight 2017 Apr 6;2(7):e90932. doi: 10.1172/jci.insight.90932. PMID: 28405618Free PMC Article
Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis.
Martí-Carvajal AJ, Anand V, Solà I
Cochrane Database Syst Rev 2015 Apr 10;2015(4):CD010298. doi: 10.1002/14651858.CD010298.pub2. PMID: 25860512Free PMC Article
Pediatric aplastic anemia and refractory cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors.
Forester CM, Sartain SE, Guo D, Harris MH, Weinberg OK, Fleming MD, London WB, Williams DA, Hofmann I
Am J Hematol 2015 Apr;90(4):320-6. Epub 2015 Mar 2 doi: 10.1002/ajh.23937. PMID: 25580823Free PMC Article
Peripheral neuropathies in Waldenström's macroglobulinaemia.
Levine T, Pestronk A, Florence J, Al-Lozi MT, Lopate G, Miller T, Ramneantu I, Waheed W, Stambuk M, Stone MJ, Choksi R
J Neurol Neurosurg Psychiatry 2006 Feb;77(2):224-8. doi: 10.1136/jnnp.2005.071175. PMID: 16421127Free PMC Article

Recent systematic reviews

Comparison of a therapeutic-only versus prophylactic platelet transfusion policy for people with congenital or acquired bone marrow failure disorders.
Malouf R, Ashraf A, Hadjinicolaou AV, Doree C, Hopewell S, Estcourt LJ
Cochrane Database Syst Rev 2018 May 14;5(5):CD012342. doi: 10.1002/14651858.CD012342.pub2. PMID: 29758592Free PMC Article
Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis.
Martí-Carvajal AJ, Anand V, Solà I
Cochrane Database Syst Rev 2015 Apr 10;2015(4):CD010298. doi: 10.1002/14651858.CD010298.pub2. PMID: 25860512Free PMC Article

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