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Benign epithelial skin neoplasm

MedGen UID:
83395
•Concept ID:
C0345981
•
Neoplastic Process
Synonyms: Benign epithelial neoplasm of skin; Benign Epithelial Skin Neoplasm; benign epithelial skin neoplasm; Benign Epithelial Skin Tumor; benign epithelial skin tumor; benign epithelial skin tumour; Benign Skin Epithelium Neoplasm; benign skin epithelium neoplasm; Benign Skin Epithelium Tumor; benign skin epithelium tumor; benign skin epithelium tumour; Benign tumor of surface epithelium; epithelial skin neoplasm, benign
SNOMED CT: Benign epithelial neoplasm of skin (254658001); Benign tumor of surface epithelium (254658001)
 
Monarch Initiative: MONDO:0024666

Definition

An epithelial neoplasm that arises from the skin and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign epithelial skin neoplasm

Professional guidelines

PubMed

The Utilization of PRAME in the Diagnosis, Prognosis, and Treatment of Melanoma.
Blount SL, Liu X, McBride JD
Cells 2024 Oct 20;13(20) doi: 10.3390/cells13201740. PMID: 39451258Free PMC Article
Clinical and histopathological profile of primary caruncular lesions.
Alam MS, Pal SS, Krishnakumar S
Indian J Ophthalmol 2022 Jun;70(6):1975-1981. doi: 10.4103/ijo.IJO_2724_21. PMID: 35647965Free PMC Article
Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Follicular Differentiation.
Płachta I, Kleibert M, Czarnecka AM, Spałek M, Szumera-Ciećkiewicz A, Rutkowski P
Int J Mol Sci 2021 Apr 30;22(9) doi: 10.3390/ijms22094759. PMID: 33946233Free PMC Article

Recent clinical studies

Etiology

Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics.
Wolf J, Kist LF, Pereira SB, Quessada MA, Petek H, Pille A, Maccari JG, Mutlaq MP, Nasi LA
Rev Med Virol 2024 May;34(3):e2537. doi: 10.1002/rmv.2537. PMID: 38666757
Genital human papillomavirus infections.
Kaliterna V, Barisic Z
Front Biosci (Landmark Ed) 2018 Mar 1;23(9):1587-1611. doi: 10.2741/4662. PMID: 29293452
The low-risk papillomaviruses.
Egawa N, Doorbar J
Virus Res 2017 Mar 2;231:119-127. Epub 2016 Dec 28 doi: 10.1016/j.virusres.2016.12.017. PMID: 28040475
Pathology of eyelid tumors.
Pe'er J
Indian J Ophthalmol 2016 Mar;64(3):177-90. doi: 10.4103/0301-4738.181752. PMID: 27146927Free PMC Article
Aluminium and the human breast.
Darbre PD
Morphologie 2016 Jun;100(329):65-74. Epub 2016 Mar 17 doi: 10.1016/j.morpho.2016.02.001. PMID: 26997127

Diagnosis

Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics.
Wolf J, Kist LF, Pereira SB, Quessada MA, Petek H, Pille A, Maccari JG, Mutlaq MP, Nasi LA
Rev Med Virol 2024 May;34(3):e2537. doi: 10.1002/rmv.2537. PMID: 38666757
Follicular mucinosis: a review.
Khalil J, Kurban M, Abbas O
Int J Dermatol 2021 Feb;60(2):159-165. Epub 2020 Sep 2 doi: 10.1111/ijd.15165. PMID: 32880923
Genital human papillomavirus infections.
Kaliterna V, Barisic Z
Front Biosci (Landmark Ed) 2018 Mar 1;23(9):1587-1611. doi: 10.2741/4662. PMID: 29293452
Noninvasive diagnosis in dermatology.
Welzel J, Schuh S
J Dtsch Dermatol Ges 2017 Oct;15(10):999-1016. doi: 10.1111/ddg.13347. PMID: 28976087
Immunohistochemical characteristics of melanoma.
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807

Therapy

Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics.
Wolf J, Kist LF, Pereira SB, Quessada MA, Petek H, Pille A, Maccari JG, Mutlaq MP, Nasi LA
Rev Med Virol 2024 May;34(3):e2537. doi: 10.1002/rmv.2537. PMID: 38666757
Genital human papillomavirus infections.
Kaliterna V, Barisic Z
Front Biosci (Landmark Ed) 2018 Mar 1;23(9):1587-1611. doi: 10.2741/4662. PMID: 29293452
Aluminium and the human breast.
Darbre PD
Morphologie 2016 Jun;100(329):65-74. Epub 2016 Mar 17 doi: 10.1016/j.morpho.2016.02.001. PMID: 26997127
Cutaneous melanoma in solid organ transplant patients.
Russo I, Piaserico S, Belloni-Fortina A, Alaibac M
G Ital Dermatol Venereol 2014 Aug;149(4):389-94. PMID: 25068225
Breast adenomas.
Hertel BF, Zaloudek C, Kempson RL
Cancer 1976 Jun;37(6):2891-905. doi: 10.1002/1097-0142(197606)37:6<2891::aid-cncr2820370647>3.0.co;2-p. PMID: 949710

Prognosis

Calcifying Epithelial Odontogenic Tumour. Review of the literature and own experience.
Piskadło T, Brodowski R, Książek M, Pakla P, Dymek M, Haberko P, Franczak J, Stopyra W, Lewandowski B
Dev Period Med 2019;23(1):34-38. doi: 10.34763/devperiodmed.20192301.3438. PMID: 30954979Free PMC Article
Topics in histopathology of sweat gland and sebaceous neoplasms.
Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768
Cutaneous melanoma in solid organ transplant patients.
Russo I, Piaserico S, Belloni-Fortina A, Alaibac M
G Ital Dermatol Venereol 2014 Aug;149(4):389-94. PMID: 25068225
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694
Immunohistochemical characteristics of melanoma.
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807

Clinical prediction guides

NEAT1/miR-200b-3p/SMAD2 axis promotes progression of melanoma.
Zhou WJ, Wang HY, Zhang J, Dai HY, Yao ZX, Zheng Z, Meng-Yan S, Wu K
Aging (Albany NY) 2020 Nov 16;12(22):22759-22775. doi: 10.18632/aging.103909. PMID: 33202380Free PMC Article
Noninvasive diagnosis in dermatology.
Welzel J, Schuh S
J Dtsch Dermatol Ges 2017 Oct;15(10):999-1016. doi: 10.1111/ddg.13347. PMID: 28976087
Syringometaplasia: variants and underlying mechanisms.
Abbas O, Bhawan J
Int J Dermatol 2016 Feb;55(2):142-8. Epub 2015 Oct 13 doi: 10.1111/ijd.13040. PMID: 26460811
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694
A comparative review of melanocytic neoplasms.
Smith SH, Goldschmidt MH, McManus PM
Vet Pathol 2002 Nov;39(6):651-78. doi: 10.1354/vp.39-6-651. PMID: 12450197

Recent systematic reviews

A systematic review of Pilomatrix carcinoma arising from the previous scar site of Pilomatrixoma.
Panda SK, Sahoo PK, Agarwala SK, Houghton TT, Sankar KV, Mohanty P
J Cancer Res Ther 2023 Jul-Sep;19(5):1098-1102. doi: 10.4103/jcrt.jcrt_720_21. PMID: 37787269
Novel approaches for managing aged skin and nonmelanoma skin cancer.
Todorova K, Mandinova A
Adv Drug Deliv Rev 2020 Jan 1;153:18-27. Epub 2020 Jun 8 doi: 10.1016/j.addr.2020.06.004. PMID: 32526451

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