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Clear cell acanthoma

MedGen UID:: 83098
•Concept ID:: C0333992
•: Neoplastic Process

Synonyms:	Acanthoma, Clear Cell; Acanthoma, Degos; Acanthomas, Clear Cell; Clear Cell Acanthoma; Clear Cell Acanthomas; Degos Acanthoma
SNOMED CT:	Clear cell acanthoma (65540008); Clear cell acanthoma (254670002); Clear cell acanthoma of Degos (254670002); Degos' acanthoma (254670002)

Monarch Initiative:	MONDO:0002086

Definition

An acanthoma characterized by the presence of psoriasiform epidermal acanthosis and basal cells with pale cytoplasm. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVClear cell acanthoma

Neoplasm
- Neoplasm by Special Category
  - Benign neoplasm
    - Benign epithelial neoplasm
      - Benign epithelial skin neoplasm
        Acanthoma
        Clear cell acanthoma

Professional guidelines

PubMed

Comparative study of treatment methods for benign lichenoid keratosis of the face.

Yoon JH, Baek EJ, Park EJ, Kim KH
Dermatol Ther 2022 May;35(5):e15419. Epub 2022 Mar 12 doi: 10.1111/dth.15419. PMID: 35246904

Lesions With an Epidermal Hyperplastic Pattern: Morphologic Clues in the Differential Diagnosis.

Fernandez-Flores A
Am J Dermatopathol 2016 Jan;38(1):1-16; quiz 17-9. doi: 10.1097/DAD.0000000000000324. PMID: 26730692

Expression of lumican in hidroacanthoma simplex and clonal-type seborrheic keratosis as a potent differential diagnostic marker.

Takayama R, Ansai S, Ishiwata T, Yamamoto T, Matsuda Y, Naito Z, Kawana S
Am J Dermatopathol 2014 Aug;36(8):655-60. doi: 10.1097/DAD.0b013e31828b6bbf. PMID: 23656908

See all (4)

Recent clinical studies

Etiology

Clear Cell Acanthoma: A Series of 70 Cases.

Marcoval J, Moreno-Vílchez C, Torrecilla-Vall-Llossera C, Muntaner-Virgili C, Penín RM
Actas Dermosifiliogr 2023 Sep;114(8):668-673. Epub 2023 Apr 29 doi: 10.1016/j.ad.2023.04.028. PMID: 37127205

Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease.

Kuo KL, Lo CS, Lee LY, Yang CH, Kuo TT
J Am Acad Dermatol 2019 Mar;80(3):749-755. Epub 2018 Dec 14 doi: 10.1016/j.jaad.2016.07.032. PMID: 30558902

Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?

Shalin SC, Rinaldi C, Horn TD
J Cutan Pathol 2013 Dec;40(12):1021-6. Epub 2013 Oct 10 doi: 10.1111/cup.12232. PMID: 24117902

Clear cell acanthoma: a rare clinical diagnosis prior to biopsy.

Morrison LK, Duffey M, Janik M, Shamma HN
Int J Dermatol 2010 Sep;49(9):1008-11. doi: 10.1111/j.1365-4632.2010.04521.x. PMID: 20931670

How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part II. Nonmelanocytic skin tumors.

Zalaudek I, Kreusch J, Giacomel J, Ferrara G, Catricalà C, Argenziano G
J Am Acad Dermatol 2010 Sep;63(3):377-86; quiz 387-8. doi: 10.1016/j.jaad.2009.11.697. PMID: 20708470

See all (10)

Diagnosis

Clear Cell Acanthoma: A Series of 70 Cases.

Marcoval J, Moreno-Vílchez C, Torrecilla-Vall-Llossera C, Muntaner-Virgili C, Penín RM
Actas Dermosifiliogr 2023 Sep;114(8):668-673. Epub 2023 Apr 29 doi: 10.1016/j.ad.2023.04.028. PMID: 37127205

Clear cell acanthoma.

Wagner G, Back W, Sachse MM
J Dtsch Dermatol Ges 2021 Jan;19(1):31-36. Epub 2020 Sep 28 doi: 10.1111/ddg.14270. PMID: 32989899

Multiple clear-cell acanthomas.

Martínez Escanamé M, Arzberger E, Hofmann-Wellenhof R, Massone C
Australas J Dermatol 2015 May;56(2):e46-8. Epub 2013 Aug 29 doi: 10.1111/ajd.12099. PMID: 23991751

Clear cell acanthoma.

Portal C, Fang F, Kanner W, Wilson B
Cutis 2013 Aug;92(2):62,77-9. PMID: 24087787

Clear cell acanthoma.

Tempark T, Shwayder T
Clin Exp Dermatol 2012 Dec;37(8):831-7. doi: 10.1111/j.1365-2230.2012.04428.x. PMID: 23171155

See all (45)

Therapy

Multiple eruptive clear cell acanthomas successfully treated with CO2 laser ablation.

Drumm C, Ngan K, Crema J, Khirwadkar N, Defty C, Eustace K
J Dermatolog Treat 2022 Aug;33(5):2687-2688. Epub 2022 Apr 21 doi: 10.1080/09546634.2022.2049587. PMID: 35238268

Clear Cell Acanthoma: Sural Nerve Entrapment and Neuropathy After Excision.

Bennett M, Sinclair R
Dermatol Surg 2021 Nov 1;47(11):1534-1535. doi: 10.1097/DSS.0000000000003234. PMID: 34608085

Bilateral clear cell acanthoma of the areola and nipple: good response to topical corticosteroids.

González-Guerra E, Rodriguez JR, Casado AF, Taboada AC, Toro JAC, Bran EL
An Bras Dermatol 2017;92(5 Suppl 1):27-29. doi: 10.1590/abd1806-4841.20175683. PMID: 29267438 Free PMC Article

Clear Cell Acanthoma of the Areola and Nipple.

Hidalgo-García Y, Gonzálvo P, Mallo-García S, Fernández-Sánchez C
Actas Dermosifiliogr 2016 Nov;107(9):793-795. Epub 2016 May 17 doi: 10.1016/j.ad.2016.04.008. PMID: 27206609

Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?

Shalin SC, Rinaldi C, Horn TD
J Cutan Pathol 2013 Dec;40(12):1021-6. Epub 2013 Oct 10 doi: 10.1111/cup.12232. PMID: 24117902

See all (8)

Prognosis

Multiple eruptive clear cell acanthomas successfully treated with CO2 laser ablation.

Drumm C, Ngan K, Crema J, Khirwadkar N, Defty C, Eustace K
J Dermatolog Treat 2022 Aug;33(5):2687-2688. Epub 2022 Apr 21 doi: 10.1080/09546634.2022.2049587. PMID: 35238268

Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases.

Veiga RR, Barros RS, Santos JE, Abreu Junior JM, Bittencourt Mde J, Miranda MF
An Bras Dermatol 2013 Jan-Feb;88(1):84-9. doi: 10.1590/s0365-05962013000100010. PMID: 23539008 Free PMC Article

A case of polypoid clear cell acanthoma on the scrotum.

Kawaguchi H, Tatewaki S, Takeuchi M
J Dermatol 2004 Mar;31(3):236-8. doi: 10.1111/j.1346-8138.2004.tb00662.x. PMID: 15187345

Psoriasis-like dermoscopic pattern of clear cell acanthoma.

Bugatti L, Filosa G, Broganelli P, Tomasini C
J Eur Acad Dermatol Venereol 2003 Jul;17(4):452-5. doi: 10.1046/j.1468-3083.2003.00754.x. PMID: 12834460

Polypoid clear cell acanthoma: case report.

Inalöz HS, Patel G, Knight AG
J Eur Acad Dermatol Venereol 2000 Nov;14(6):511-2. doi: 10.1046/j.1468-3083.2000.00141.x. PMID: 11444278

See all (7)

Clinical prediction guides

Clear Cell Acanthoma on the Areola.

Borda LJ, Mervis JS, Romanelli P, Lev-Tov H
Dermatol Online J 2018 Jul 15;24(7) PMID: 30261576

Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma.

Scanni G, Pellacani G
An Bras Dermatol 2014 Sep-Oct;89(5):803-5. doi: 10.1590/abd1806-4841.20143079. PMID: 25184922 Free PMC Article

Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?

Shalin SC, Rinaldi C, Horn TD
J Cutan Pathol 2013 Dec;40(12):1021-6. Epub 2013 Oct 10 doi: 10.1111/cup.12232. PMID: 24117902

Psoriasis-like dermoscopic pattern of clear cell acanthoma.

Bugatti L, Filosa G, Broganelli P, Tomasini C
J Eur Acad Dermatol Venereol 2003 Jul;17(4):452-5. doi: 10.1046/j.1468-3083.2003.00754.x. PMID: 12834460

Lectin-binding sites in clear cell acanthoma.

Akiyama M, Hayakawa K, Watanabe Y, Nishikawa T
J Cutan Pathol 1990 Aug;17(4):197-201. doi: 10.1111/j.1600-0560.1990.tb00084.x. PMID: 2394862

See all (8)

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Clear cell acanthoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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