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Chronic Myelomonocytic Leukemia with Eosinophilia

MedGen UID:
232364
Concept ID:
C1333045
Neoplastic Process
Synonym: CMML with Eosinophilia

Definition

A chronic myelomonocytic leukemia characterized by a peripheral blood eosinophil count of equal or greater than 1.5x10E9/L, and absence of PDGFRA or PDGFRB gene abnormalities. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic Myelomonocytic Leukemia with Eosinophilia

Professional guidelines

PubMed

Patnaik MM, Tefferi A
Am J Hematol 2023 Apr;98(4):681-689. Epub 2023 Jan 4 doi: 10.1002/ajh.26828. PMID: 36601682
Vardiman J, Hyjek E
Hematology Am Soc Hematol Educ Program 2011;2011:250-6. doi: 10.1182/asheducation-2011.1.250. PMID: 22160042
Tefferi A, Elliott MA, Pardanani A
Mayo Clin Proc 2006 Apr;81(4):553-63. doi: 10.4065/81.4.553. PMID: 16610578

Recent clinical studies

Etiology

Patnaik MM, Tefferi A
Am J Hematol 2023 Apr;98(4):681-689. Epub 2023 Jan 4 doi: 10.1002/ajh.26828. PMID: 36601682
Tang G, Tam W, Short NJ, Bose P, Wu D, Hurwitz SN, Bagg A, Rogers HJ, Hsi ED, Quesada AE, Wang W, Miranda RN, Bueso-Ramos CE, Medeiros LJ, Nardi V, Hasserjian RP, Arber DA, Orazi A, Foucar K, Wang SA
Mod Pathol 2021 Sep;34(9):1673-1685. Epub 2021 May 14 doi: 10.1038/s41379-021-00817-7. PMID: 33990705
Butterfield JH, Weiler CR
Am J Hematol 2013 May;88(5):406-8. Epub 2013 Mar 27 doi: 10.1002/ajh.23426. PMID: 23436294
Vardiman J, Hyjek E
Hematology Am Soc Hematol Educ Program 2011;2011:250-6. doi: 10.1182/asheducation-2011.1.250. PMID: 22160042
Gotlib J
Acta Haematol 2005;114(1):7-25. doi: 10.1159/000085559. PMID: 15995322

Diagnosis

Patnaik MM, Tefferi A
Am J Hematol 2023 Apr;98(4):681-689. Epub 2023 Jan 4 doi: 10.1002/ajh.26828. PMID: 36601682
Cross NCP
Clin Lymphoma Myeloma Leuk 2020 Sep;20 Suppl 1:S101-S102. doi: 10.1016/S2152-2650(20)30477-8. PMID: 32862848
Cessna MH, Paulraj P, Hilton B, Sadre-Bazzaz K, Szankasi P, Cluff A, Patel JL, Hoda D, Toydemir RM
Cancer Genet 2019 Oct;238:31-36. Epub 2019 Jul 13 doi: 10.1016/j.cancergen.2019.07.004. PMID: 31425923
Falchi L, Verstovsek S
Immunol Allergy Clin North Am 2015 Aug;35(3):439-52. doi: 10.1016/j.iac.2015.04.004. PMID: 26209894Free PMC Article
Tefferi A, Gotlib J, Pardanani A
Mayo Clin Proc 2010 Feb;85(2):158-64. Epub 2010 Jan 6 doi: 10.4065/mcp.2009.0503. PMID: 20053713Free PMC Article

Therapy

Falchi L, Verstovsek S
Immunol Allergy Clin North Am 2015 Aug;35(3):439-52. doi: 10.1016/j.iac.2015.04.004. PMID: 26209894Free PMC Article
Cheah CY, Burbury K, Apperley JF, Huguet F, Pitini V, Gardembas M, Ross DM, Forrest D, Genet P, Rousselot P, Patton N, Smith G, Dunbar CE, Ito S, Aguiar RC, Odenike O, Gimelfarb A, Cross NC, Seymour JF
Blood 2014 Jun 5;123(23):3574-7. Epub 2014 Mar 31 doi: 10.1182/blood-2014-02-555607. PMID: 24687085Free PMC Article
Iastrebner M, Jang JH, Nucifora E, Kim K, Sackmann F, Kim DH, Orlando S, Jung CW, Basquiera A, Klein G, Santini F, Bernard HI, Korin J, Taborda G
Leuk Lymphoma 2010 Dec;51(12):2250-7. Epub 2010 Oct 7 doi: 10.3109/10428194.2010.524324. PMID: 20929328
Tefferi A, Gotlib J, Pardanani A
Mayo Clin Proc 2010 Feb;85(2):158-64. Epub 2010 Jan 6 doi: 10.4065/mcp.2009.0503. PMID: 20053713Free PMC Article
Tefferi A, Pardanani A
Int J Hematol 2004 Jun;79(5):441-7. doi: 10.1532/ijh97.04046. PMID: 15239393

Prognosis

Cross NCP
Clin Lymphoma Myeloma Leuk 2020 Sep;20 Suppl 1:S101-S102. doi: 10.1016/S2152-2650(20)30477-8. PMID: 32862848
Cessna MH, Paulraj P, Hilton B, Sadre-Bazzaz K, Szankasi P, Cluff A, Patel JL, Hoda D, Toydemir RM
Cancer Genet 2019 Oct;238:31-36. Epub 2019 Jul 13 doi: 10.1016/j.cancergen.2019.07.004. PMID: 31425923
Lasho TL, Finke CM, Zblewski D, Patnaik M, Ketterling RP, Chen D, Hanson CA, Tefferi A, Pardanani A
Blood Cancer J 2015 Jan 23;5(1):e275. doi: 10.1038/bcj.2014.94. PMID: 25615281Free PMC Article
Butterfield JH, Weiler CR
Am J Hematol 2013 May;88(5):406-8. Epub 2013 Mar 27 doi: 10.1002/ajh.23426. PMID: 23436294
Bain BJ
Leuk Lymphoma 1999 Aug;34(5-6):443-9. doi: 10.3109/10428199909058471. PMID: 10492067

Clinical prediction guides

Tang G, Tam W, Short NJ, Bose P, Wu D, Hurwitz SN, Bagg A, Rogers HJ, Hsi ED, Quesada AE, Wang W, Miranda RN, Bueso-Ramos CE, Medeiros LJ, Nardi V, Hasserjian RP, Arber DA, Orazi A, Foucar K, Wang SA
Mod Pathol 2021 Sep;34(9):1673-1685. Epub 2021 May 14 doi: 10.1038/s41379-021-00817-7. PMID: 33990705
Zhang H, Paliga A, Hobbs E, Moore S, Olson S, Long N, Dao KT, Tyner JW
Cold Spring Harb Mol Case Stud 2018 Dec;4(6) Epub 2018 Dec 17 doi: 10.1101/mcs.a003079. PMID: 30559310Free PMC Article
Lasho TL, Finke CM, Zblewski D, Patnaik M, Ketterling RP, Chen D, Hanson CA, Tefferi A, Pardanani A
Blood Cancer J 2015 Jan 23;5(1):e275. doi: 10.1038/bcj.2014.94. PMID: 25615281Free PMC Article
Butterfield JH, Weiler CR
Am J Hematol 2013 May;88(5):406-8. Epub 2013 Mar 27 doi: 10.1002/ajh.23426. PMID: 23436294
Wlodarska I, Mecucci C, Baens M, Marynen P, van den Berghe H
Leuk Lymphoma 1996 Oct;23(3-4):287-95. doi: 10.3109/10428199609054831. PMID: 9031109

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