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Acute myeloblastic leukemia without maturation

MedGen UID:
10232
Concept ID:
C0026998
Neoplastic Process
Synonyms: Acute Myeloid Leukemia without Maturation; Leukemia, Myeloid, Acute, M1; Myeloid Leukemia, Acute, M1
SNOMED CT: Acute myeloid leukemia without maturation (103690005); Acute myeloblastic leukemia without maturation (103690005); Acute granulocytic leukemia without maturation (103690005); Acute myelogenous leukemia without maturation (103690005); Acute myelocytic leukemia without maturation (103690005); FAB M1 (103690005); Acute myelogenous leukemia without maturation (359640008); M1 - Acute myeloblastic leukemia without maturation (359640008); Acute myeloid leukemia without maturation, FAB M1 (359640008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005224
Orphanet: ORPHA98833

Definition

A rare, acute myeloid leukemia characterized by no significant myeloid maturation and more than 90% blast cells in the non-erythroid population. Various degrees of anemia, thrombocytopenia, or pancytopenia are present. Frequent clinical manifestations include fatigue, fever, bleeding disorders, and organomegaly, especially hepatosplenomegaly. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute myeloblastic leukemia without maturation

Professional guidelines

PubMed

Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Shimony S, Stahl M, Stone RM
Am J Hematol 2023 Mar;98(3):502-526. Epub 2023 Jan 13 doi: 10.1002/ajh.26822. PMID: 36594187
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514

Recent clinical studies

Etiology

Sultan S, Zaheer HA, Irfan SM, Ashar S
Asian Pac J Cancer Prev 2016;17(1):369-72. doi: 10.7314/apjcp.2016.17.1.369. PMID: 26838239
Hamamoto K, Date M, Taniguchi H, Nagano T, Kishimoto Y, Kimura T, Fukuhara S
Ultrastruct Pathol 1995 Jan-Feb;19(1):9-14. doi: 10.3109/01913129509014598. PMID: 7770965
Cousar JB, Briggs RC
Leuk Res 1990;14(10):915-20. doi: 10.1016/0145-2126(90)90182-9. PMID: 2259228
Matsuo T, Cox C, Bennett JM
Hematol Pathol 1989;3(4):153-8. PMID: 2560775

Diagnosis

Sultan S, Zaheer HA, Irfan SM, Ashar S
Asian Pac J Cancer Prev 2016;17(1):369-72. doi: 10.7314/apjcp.2016.17.1.369. PMID: 26838239

Therapy

Hamamoto K, Date M, Taniguchi H, Nagano T, Kishimoto Y, Kimura T, Fukuhara S
Ultrastruct Pathol 1995 Jan-Feb;19(1):9-14. doi: 10.3109/01913129509014598. PMID: 7770965

Prognosis

Hamamoto K, Date M, Taniguchi H, Nagano T, Kishimoto Y, Kimura T, Fukuhara S
Ultrastruct Pathol 1995 Jan-Feb;19(1):9-14. doi: 10.3109/01913129509014598. PMID: 7770965
Matsuo T, Cox C, Bennett JM
Hematol Pathol 1989;3(4):153-8. PMID: 2560775

Clinical prediction guides

Sultan S, Zaheer HA, Irfan SM, Ashar S
Asian Pac J Cancer Prev 2016;17(1):369-72. doi: 10.7314/apjcp.2016.17.1.369. PMID: 26838239
Hamamoto K, Date M, Taniguchi H, Nagano T, Kishimoto Y, Kimura T, Fukuhara S
Ultrastruct Pathol 1995 Jan-Feb;19(1):9-14. doi: 10.3109/01913129509014598. PMID: 7770965
Matsuo T, Cox C, Bennett JM
Hematol Pathol 1989;3(4):153-8. PMID: 2560775

Supplemental Content

Table of contents

    Clinical resources

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