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Refractory B Acute Lymphoblastic Leukemia with BCR-ABL1-Like Features

MedGen UID:
1626003
•Concept ID:
C4525407
•
Neoplastic Process
Synonyms: Refractory B-Acute Lymphoblastic Leukemia with BCR::ABL1-Like Features; Refractory Ph-Like Acute Lymphoblastic Leukemia

Definition

B acute lymphoblastic leukemia with BCR-ABL1-like features that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory B Acute Lymphoblastic Leukemia with BCR-ABL1-Like Features

Recent clinical studies

Diagnosis

Identification of RNPC3 as a novel JAK2 fusion partner gene in B-acute lymphoblastic leukemia refractory to combination therapy including ruxolitinib.
Chen X, Wang F, Zhang Y, Ma X, Liu M, Cao P, Zhou L, Wang L, Zhang X, Wang T, Liu H
Mol Genet Genomic Med 2020 Mar;8(3):e1110. Epub 2019 Dec 30 doi: 10.1002/mgg3.1110. PMID: 31885183Free PMC Article

Therapy

Identification of RNPC3 as a novel JAK2 fusion partner gene in B-acute lymphoblastic leukemia refractory to combination therapy including ruxolitinib.
Chen X, Wang F, Zhang Y, Ma X, Liu M, Cao P, Zhou L, Wang L, Zhang X, Wang T, Liu H
Mol Genet Genomic Med 2020 Mar;8(3):e1110. Epub 2019 Dec 30 doi: 10.1002/mgg3.1110. PMID: 31885183Free PMC Article

Prognosis

Identification of RNPC3 as a novel JAK2 fusion partner gene in B-acute lymphoblastic leukemia refractory to combination therapy including ruxolitinib.
Chen X, Wang F, Zhang Y, Ma X, Liu M, Cao P, Zhou L, Wang L, Zhang X, Wang T, Liu H
Mol Genet Genomic Med 2020 Mar;8(3):e1110. Epub 2019 Dec 30 doi: 10.1002/mgg3.1110. PMID: 31885183Free PMC Article

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