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| Status |
Public on Feb 02, 2016 |
| Title |
Development of gene signatures of human unipotent megakaryocyte progenitor and other hematopoietic stem and progenitor populations |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We newly identified prospectively-isolatable unipotent megakaryocyte progenitor population (MegP) as the major source of megakaryocytes, which emerges directly from early stage of hematopoiesis bypassing megakaryocyte-erythroid lineage bifurcation and contributes to physiological and pathological human megakaryopoiesis. To explore gene expression signature of hematopoietic stem/progenitor populrations miroarry-based whole transcriptome analysis was performed. As a result, gene expression signature of MegP clearly reflected its differentiation potential.
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| Overall design |
Gene expression profile of megakaryocyte progenitor and other hematopoietic stem and progenitor populations (Manz et al., PNAS, 2002), which were derived from bone marrow aspirates, were analyzed.
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| Contributor(s) |
Miyawaki K |
| Citation(s) |
28336526 |
| |
| Submission date |
Feb 01, 2016 |
| Last update date |
Apr 09, 2020 |
| Contact name |
Kohta Miyawaki |
| E-mail(s) |
kohtam@gmail.com
|
| Organization name |
Kyushu University
|
| Street address |
3-1-1, Maidashi, Higashi-ku
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| City |
Fukuoka |
| ZIP/Postal code |
812-8582 |
| Country |
Japan |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (21)
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| Relations |
| BioProject |
PRJNA310336 |
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