GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE55036 Query DataSets for GSE55036
Status Public on Jun 05, 2015
Title Expression data from skin biopsies in pateints with systemic sclerosis treated with anti-TGF-beta, fresolimumab
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Systemic sclerosis is associated with skin fibrosis thought mediated by TGFb. This open label clinical trial examines the effect of TGFb inhibition on skin gene expression.
Patients 1-9 received two doses 1 mg/kg dose of fresolimumab at baseline and 3 weeks; patients 10-19 received a single 5 mg/kg dose
Overall design Patients with diffuse cutaneous systemic sclerosis within 2 years of first raynauds had skin biopsies before treatment and the 3-4 weeks, 7 weeks and 24 weeks after treatment with fresolimumab
Contributor(s) Lafyatis R
Citation(s) 26098215
Submission date Feb 14, 2014
Last update date Apr 16, 2021
Contact name Robert Lafyatis
Phone 6176385388
Organization name Boston University School of Medicine
Department Rheumatology
Street address 72 E Concord St
City Boston
State/province MA
ZIP/Postal code 02118
Country USA
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (53)
GSM1328197 Patient 1 - skin-baseline visit
GSM1328198 Patient 1 - skin-week 3/4 visit
GSM1328199 Patient 1 - skin-week 7 visit
BioProject PRJNA238310

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE55036_RAW.tar 101.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap