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| Status |
Public on Sep 04, 2008 |
| Title |
Gene expression from human prefrontal cortex (BA10) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We performed the oligonucleotide microarray analysis in bipolar disorder, major depression, schizophrenia, and control subjects using postmortem prefrontal cortices provided by the Stanley Foundation Brain Collection. By comparing the gene expression profiles of similar but distinctive mental disorders, we explored the uniqueness of bipolar disorder and its similarity to other mental disorders at the molecular level. Notably, most of the altered gene expressions in each disease were not shared by one another, suggesting the molecular distinctiveness of these mental disorders. We found a tendency of downregulation of the genes encoding receptor, channels or transporters, and upregulation of the genes encoding stress response proteins or molecular chaperons in bipolar disorder. Altered expressions in bipolar disorder shared by other mental disorders mainly consisted of upregulation of the genes encoding proteins for transcription or translation. The genes identified in this study would be useful for the understanding of the pathophysiology of bipolar disorder, as well as the common pathophysiological background in major mental disorders at the molecular level.
Keywords: disease state analysis
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| Overall design |
A total of 50 postmortem brains obtained from the Stanley Medical Research Institute were used for DNA microarray analysis. Fresh frozen samples were used for RNA extraction.
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| Contributor(s) |
Iwamoto K, Kakiuchi C, Bundo M, Ikeda K, Kato T |
| Citation(s) |
14743183 |
| Submission date |
Sep 03, 2008 |
| Last update date |
Dec 13, 2018 |
| Contact name |
Kazuya Iwamoto |
| E-mail(s) |
kaziwamoto@brain.riken.jp
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| Phone |
+81-48-467-6949
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| Fax |
+81-48-467-6947
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| URL |
http://www.brain.riken.go.jp/labs/mdmd/indexe.htm
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| Organization name |
RIKEN
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| Department |
Brain Science Institute
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| Lab |
Lab for Molecular Dynamics of Mental Disorders
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| Street address |
2-1 Hirosawa
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| City |
Wako |
| ZIP/Postal code |
351-0198 |
| Country |
Japan |
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| Platforms (1) |
| GPL8300 |
[HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array |
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| Samples (50)
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| GSM317652 |
control, BA10-4(2) |
| GSM317653 |
bipolar disorder, BA10-5 |
| GSM317654 |
schizophrenia, BA10-6(2) |
| GSM317655 |
schizophrenia, BA10-7(2) |
| GSM317656 |
bipolar disorder, BA10-8(2) |
| GSM317657 |
depression, BA10-9 |
| GSM317658 |
bipolar disorder, BA10-11 |
| GSM317659 |
schizophrenia, BA10-12(3) |
| GSM317660 |
bipolar disorder, BA10-13(2) |
| GSM317661 |
schizophrenia, BA10-14(2) |
| GSM317662 |
schizophrenia, BA10-15 |
| GSM317663 |
bipolar disorder, BA10-16 |
| GSM317664 |
bipolar disorder, BA10-18 |
| GSM317665 |
bipolar disorder, BA10-19 |
| GSM317666 |
control, BA10-21 |
| GSM317667 |
depression, BA10-22(4) |
| GSM317668 |
schizophrenia, BA10-25 |
| GSM317669 |
schizophrenia, BA10-26 |
| GSM317670 |
depression, BA10-28(2) |
| GSM317671 |
schizophrenia, BA10-29 |
| GSM317672 |
control, BA10-30 |
| GSM317673 |
bipolar disorder, BA10-31 |
| GSM317674 |
depression, BA10-33 |
| GSM317675 |
depression, BA10-35 |
| GSM317676 |
schizophrenia, BA10-37(3) |
| GSM317677 |
depression, BA10-38 |
| GSM317678 |
depression, BA10-39 |
| GSM317679 |
control, BA10-40 |
| GSM317680 |
schizophrenia, BA10-41 |
| GSM317681 |
control, BA10-42 |
| GSM317682 |
control, BA10-43 |
| GSM317683 |
control, BA10-44 |
| GSM317684 |
schizophrenia, BA10-45 |
| GSM317685 |
schizophrenia, BA10-46 |
| GSM317686 |
bipolar disorder, BA10-47 |
| GSM317687 |
depression, BA10-48 |
| GSM317688 |
bipolar disorder, BA10-49 |
| GSM317689 |
control, BA10-50(2) |
| GSM317690 |
bipolar disorder, BA10-51 |
| GSM317691 |
control, BA10-53 |
| GSM317692 |
control, BA10-54 |
| GSM317693 |
control, BA10-55 |
| GSM317694 |
schizophrenia, BA10-56 |
| GSM317695 |
depression, BA10-57 |
| GSM317696 |
control, BA10-58 |
| GSM317697 |
control, BA10-59 |
| GSM317698 |
control, BA10-60 |
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| Relations |
| BioProject |
PRJNA113059 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE12654_RAW.tar |
135.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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