GEO DataSets

(Submitter supplied) The present study used microarray expression profiling to determine the effects of embryonic arsenic exposure. Fertilized killifish (Fundulus heteroclitus) eggs were exposed to 0, 5, 15, or 25ppm arsenic as sodium arsenite. To examine differentially expressed genes, the microarrays were probed using RNA obtained from the control and 25ppm-exposed killifish just after hatching. No differences were noted in survival or hatching success between any of the groups. more...

Organism:

Fundulus heteroclitus

Type:

Expression profiling by array

Platform:

GPL13723

20 Samples

Download data: TXT

(Submitter supplied) The Atlantic killifish (Fundulus heteroclitus), native to estuarine areas of the Atlantic coast of the United States, has become a valuable ecotoxicological model due to its ability to acclimate to rapid environmental changes and adapt to polluted habitats. Killifish respond to rapid increases in salinity with an immediate change in gene expression, as well as long-term remodeling of the gills. Arsenic, a major environmental toxicant, was previously shown to inhibit the ability of killifish gill to respond to a rapid increase in salinity. more...

Organism:

Fundulus heteroclitus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL25194

24 Samples

Download data: FA, TXT

(Submitter supplied) The changes in the transcriptome of Fundulus heteroclitus embryos incubated in water or in air from the blastula stage was investigated.

Organism:

Fundulus heteroclitus

Type:

Expression profiling by array

Platform:

GPL9786

42 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Pseudopleuronectes americanus; Fundulus heteroclitus

Type:

Expression profiling by array

Platform:

GPL2535

80 Samples

Download data: XLS

(Submitter supplied) The present study investigated arsenic’s effects on mummichogs (Fundulus heteroclitus), while also examining what role that gender or age of exposure might play. Adult male and female mummichogs were exposed to 172ppb, 575ppb, or 1,720ppb arsenic as sodium arsenite for 10 days immediately prior to spawning. No differences were noted in the number or viability of eggs between the groups, but there was a significant increase in deformities in the 1,720ppb arsenic exposure group. more...

Organism:

Fundulus heteroclitus; Pseudopleuronectes americanus

Type:

Expression profiling by array

Platform:

GPL2535

20 Samples

Download data: XLS

(Submitter supplied) The present study investigated arsenic’s effects on mummichogs (Fundulus heteroclitus), while also examining what role that gender or age of exposure might play. Adult male and female mummichogs were exposed to 172ppb, 575ppb, or 1,720ppb arsenic as sodium arsenite for 10 days immediately prior to spawning. No differences were noted in the number or viability of eggs between the groups, but there was a significant increase in deformities in the 1,720ppb arsenic exposure group. more...

Organism:

Pseudopleuronectes americanus; Fundulus heteroclitus

Type:

Expression profiling by array

Platform:

GPL2535

30 Samples

Download data: XLS

(Submitter supplied) The present study investigated arsenic’s effects on mummichogs (Fundulus heteroclitus), while also examining what role that gender or age of exposure might play. Adult male and female mummichogs were exposed to 172ppb, 575ppb, or 1,720ppb arsenic as sodium arsenite for 10 days immediately prior to spawning. No differences were noted in the number or viability of eggs between the groups, but there was a significant increase in deformities in the 1,720ppb arsenic exposure group. more...

Organism:

Pseudopleuronectes americanus; Fundulus heteroclitus

Type:

Expression profiling by array

Platform:

GPL2535

30 Samples

Download data: XLS

(Submitter supplied) RNA from PCB-126 exposed 10 days post-fertilization (dpf) embryos were sequenced to characterize the chemical exposure response of killifish from a PCB-resistant population (NBH, New Bedford Harbor, MA, Superfund site) as compared to a reference (SC, Scorton Creek, MA) population. Since the genome sequence was not available, we also performed shot-gun sequencing of RNA from 1-15 dpf embryos sampled every day from both populations to serve as a transcriptome assembly. more...

Organism:

Fundulus heteroclitus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22406

6 Samples

Download data: FNA, XLSX

(Submitter supplied) This study presents statistical analyses of gene expression in 5, 10 and 15 day post-fertilization (dpf) embryos of the teleost Fundulus heteroclitus treated with control vehicle (DMSO) or a potent non-ortho-PCB (PCB-126; 3,3’,4,4’,5-pentachlorobiphenyl). The embryos were from two populations: a clean, reference population (SC, Scorton Creek, MA USA) and a polluted Superfund population (N, New Bedford Harbor, MA USA). more...

Organism:

Fundulus heteroclitus

Type:

Expression profiling by array

Platform:

GPL10430

72 Samples

Download data: TXT

(Submitter supplied) Subspecies of the Atlantic killifish, Fundulus heteroclitus, differ in their maximum thermal tolerance. To determine whether there is a link between the heat shock response (HSR) and maximum thermal tolerance, we exposed 20ºC acclimated killifish from these subspecies to a 2hr heat shock at 34ºC and examined gene expression during heat shock and recovery using real time quantitative PCR and a heterologous cDNA microarray designed for salmonid fishes. more...

Organism:

Oncorhynchus mykiss; Oncorhynchus tshawytscha; Osmerus mordax; Salmo salar; Fundulus heteroclitus; Coregonus clupeaformis

Type:

Expression profiling by array

Platform:

GPL2716

16 Samples

Download data: MEV

(Submitter supplied) In the present study, we employed the RNA sequencing platform to examine the molecular response of zebrafish liver to arsenic exposure and carry out detailed transcriptomic analyses for further understanding of molecular toxicity. We found that several important biological processes were perturbed by arsenic exposure, including oxidation reduction, translation, iron ion transport, cell redox and homeostasis, as well as related pathways in metabolism and diseases. more...

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16034

2 Samples

Download data: TXT

(Submitter supplied) We demonstrate that expression of key markers of keratinocyte differentiation is suppressed by exposure to sodium arsenite. Folate deficiency exacerbates this effect. In addition, cancer-related cell movement genes, and growth and proliferation genes are altered. Several redox-sensitive transcription factors are implicated in mediating these gene expression changes due to arsenic treatment and folate deficiency. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2872

Platform:

GPL1261

24 Samples

Download data: CEL

Analysis of skin from transgenic K6/ODC animals maintained on a folate deficient diet and exposed to 1 or 10 ppm sodium arsenate. K6/ODC mice develop skin tumors when exposed to sodium arsenite. Results provide insight into the combined effect of folate deficiency and arsenic on the skin.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 3 dose, 2 protocol sets

Platform:

GPL1261

Series:

GSE8733

24 Samples

Download data: CEL

(Submitter supplied) Although alternative Flame Retardant (FR) chemicals are expected to be safer than the legacy FRs they replace, their risks to human health and the environment are often poorly characterized. This study used a small volume, fish embryo system to reveal potential mechanisms of action and diagnostic exposure patterns for TBPH (bis (2-ethylhexyl)-tetrabromophthalate), a component of several widely-used commercial products. more...

Organism:

Fundulus heteroclitus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25254

48 Samples

Download data: TXT

(Submitter supplied) Arsenic is a carcinogenic metalloid element found naturally in the environment; however human activities such as mining and pesticide use have led to increased concentrations in some areas. Silurana tropicalis eggs were exposed to sublethal concentrations of sodium arsenate (0, 0.5 and 1 ppm) for 3 days during embryogenesis. Four pooled of 10 larvae were sampled per treatment and analyzed for gene expression changes using a microarray approach.

Organism:

Xenopus tropicalis

Type:

Expression profiling by array

Platform:

GPL15626

16 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Methylation profiling by genome tiling array

Platforms:

GPL16356 GPL16284

48 Samples

Download data: CEL, PAIR

(Submitter supplied) Arsenic is methylated during its metabolism, thereby depleting the intracellular methyl donor S-adenosyl-methionine, which may lead to disturbances in DNA methylation patterns

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL16284

24 Samples

Download data: PAIR

(Submitter supplied) Arsenic is methylated during its metabolism, thereby depleting the intracellular methyl donor S-adenosyl-methionine, which may lead to disturbances in DNA methylation patterns which could lead to altered gene expression

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16356

24 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Meleagris gallopavo

Type:

Expression profiling by array

Platform:

GPL9788

70 Samples

Download data: GPR

(Submitter supplied) The purpose of Experiment 2 was two-fold: a) to evaluate a unique set of negative, distance, and mismatch control probes on the newly designed 6K TSKMLO microarray, and b) to identify differences in gene expression between two genetic lines of turkeys that phenotypically display differences in growth. Negative and mismatch controls confirmed specific hybridization using this array, and genes identified as differentially expressed between developmental stages by microarray analysis were confirmed by qRT-PCR. more...

Organism:

Meleagris gallopavo

Type:

Expression profiling by array

Platform:

GPL9788

30 Samples

Download data: GPR