Analysis of skin from transgenic K6/ODC animals maintained on a folate deficient diet and exposed to 1 or 10 ppm sodium arsenate. K6/ODC mice develop skin tumors when exposed to sodium arsenite. Results provide insight into the combined effect of folate deficiency and arsenic on the skin.
Nelson GM, Ahlborn GJ, Delker DA, Kitchin KT et al. Folate deficiency enhances arsenic effects on expression of genes involved in epidermal differentiation in transgenic K6/ODC mouse skin. Toxicology 2007 Nov 30;241(3):134-45. PMID: 17928125
