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| Status |
Public on Sep 17, 2014 |
| Title |
Sodium arsenite induced DNA methylation changes in A549 human epithelial lung carcinoma cells |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
|
| Summary |
Arsenic is methylated during its metabolism, thereby depleting the intracellular methyl donor S-adenosyl-methionine, which may lead to disturbances in DNA methylation patterns
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| |
|
| Overall design |
Cells were exposed to sodium arsenite (NaAsO2, Sigma) at concentrations of 0.08 µM, 0.4 µM and 2 µM for 1, 2 and 8 weeks. A549 arsenic dose time response study.
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| |
|
| Contributor(s) |
van Breda SG |
| Citation(s) |
25199682 |
| |
| Submission date |
Feb 08, 2013 |
| Last update date |
Sep 17, 2014 |
| Contact name |
Simone G van Breda |
| E-mail(s) |
s.vanbreda@maastrichtuniversity.nl
|
| Phone |
0031433882127
|
| Organization name |
Maastricht University
|
| Department |
Toxicogenomics
|
| Street address |
Universiteitssingel 50
|
| City |
Maastricht |
| State/province |
Limburg |
| ZIP/Postal code |
6229 ER |
| Country |
Netherlands |
| |
|
| Platforms (1) |
| GPL16284 |
NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1] |
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| Samples (24)
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| This SubSeries is part of SuperSeries: |
| GSE44174 |
Sodium arsenite induced changes in A549 human epithelial lung carcinoma cells |
|
| Relations |
| BioProject |
PRJNA188955 |
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