Similar studies for GEO DataSets (Select 200012428) - GEO DataSets

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Items: 20

Select item 2000124281.

Current smoking-specific gene expression signature in bronchial epithelium is enhanced in squamous cell lung cancer

(Submitter supplied) Cigarette smoking is the main risk factor for the development of squamous cell lung carcinoma (SCC). However, the smoking-related molecular changes in SCC have not been studied. We wanted to identify genes in both histologically normal bronchial epithelium and SCC samples that are differentially expressed between current and ex-smokers. In addition, to analyze the levels of the smoking-related genes identified in normal bronchial epithelium with the levels in SCC. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL1708
62 Samples

Download data: PDF, TXT

Series

Accession:: GSE12428

ID:: 200012428

Select item 2000160252.

miRNA prognostic profiles in lung cancer

(Submitter supplied) Non-small-cell lung cancer (NSCLC), which is comprised mainly of adenocarcinoma and squamous cell carcinoma (SCC), is the cause of 80% of all lung cancer deaths in the US. NSCLC is also associated with a high rate of relapse following clinical treatment and therefore requires robust prognostic markers to better manage therapy options. The aim of this study was to identify miRNA expression profiles in squamous cell carcinoma (SSC) of the lung that would better predict prognosis.

Organism:: Homo sapiens; Mus musculus; Rattus norvegicus

Type:: Non-coding RNA profiling by array

Platform:: GPL5106
71 Samples

Download data: TXT

Series

Accession:: GSE16025

ID:: 200016025

Select item 2000364953.

Miscellaneous unmatched samples

(Submitter supplied) unmatched samples

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL2845
4 Samples

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Series

Accession:: GSE36495

ID:: 200036495

Select item 2000109394.

Non-small Cell Lung Cancer (qRT-PCR)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL2845
105 Samples

Download data: TXT

Series

Accession:: GSE10939

ID:: 200010939

Select item 2000109375.

Gene expression differences between matched tumor and normal samples of NSCLC patients (qRT-PCR)

(Submitter supplied) Gene expression differences between between matched tumor and normal samples were analyzed using paired t-test. Keywords: disease state analysis

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL2845
90 Samples

Download data: TXT

Series

Accession:: GSE10937

ID:: 200010937

Select item 2000109366.

Gene expression differences between adenocarcinoma and squamous cell carcinoma in human NSCLC (qRT-PCR)

(Submitter supplied) Gene expression differences between the tumor subtypes AC and SCC were analyzed using t-test. Keywords: disease subtype analysis

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL2845
56 Samples

Download data: TXT

Series

Accession:: GSE10936

ID:: 200010936

Select item 2000102457.

Gene expression differences between adenocarcinoma and squamous cell carcinoma in human NSCLC

(Submitter supplied) Non-small cell lung cancer (NSCLC) can be classified into the major subtypes adenocarcinoma (AC) and squamous cell carcinoma (SCC) subtypes. Although explicit molecular, histological and clinical characteristics have been reported for both subtypes, no specific therapy exists so far. However, the characterization of suitable molecular targets holds great promises to develop novel therapies in NSCLC. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3627
Platform:: GPL570
58 Samples

Download data: CEL

Series

Accession:: GSE10245

ID:: 200010245

Select item 36278.

Non-small lung cancer subtypes: adenocarcinoma and squamous cell carcinoma

Comparison of two non-small cell lung cancer histological subtypes: adenocarcinomas (AC) and squamous cell carcinomas (SCC). Results provide insight into the molecular differences between AC and SCC.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 disease state sets

Platform:: GPL570
Series:: GSE10245
58 Samples

Download data: CEL

DataSet

Accession:: GDS3627

ID:: 3627

Select item 2000124729.

(Submitter supplied) Chronic obstructive pulmonary disease (COPD) and squamous cell lung carcinoma (SCC) are both smoking-related diseases. Interestingly, COPD itself is a risk factor for SCC, and this is independent of smoking history. Inferring from this knowledge, it is plausible to assume that patients with COPD may have a different gene expression profile in normal bronchial epithelium and in SCC. To test this hypothesis, we compared gene expression profiles in bronchial epithelium and in SCC from patients with and without COPD. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL1708
63 Samples

Download data: TXT

Series

Accession:: GSE12472

ID:: 200012472

Select item 20001228010.

Specific genomic aberrations in squamous cell lung carcinoma with lymph node or distant metastasis

(Submitter supplied) The majority of patients with squamous cell lung cancer (SCC) die because of metastatic disease. The genomic mechanisms underlying this metastatic behaviour are underexposed. We analyzed a cohort of patients with primary squamous cell carcinoma (SCC) using array-based comparative genomic hybridization (aCGH) to identify which genomic aberrations were related metastatic behaviour. The cohort consisted of 34 patients with a follow-up of at least 5 years, including 15 without any metastases, 8 with metastases in regional lymph nodes only, and 11 with metastases exclusively in distant organs within two years after surgery. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL7096
34 Samples

Download data: TXT

Series

Accession:: GSE12280

ID:: 200012280

Select item 20000411511.

Airway Epithelial Gene Expression Diagnostic for the Evaluation of Smokers with Suspect Lung Cancer

(Submitter supplied) RNA was obtained from histologically normal bronchial epithelium of smokers during time of clinical bronchoscopy from relatively accessible airway tissue. Gene expression data from smokers with lung cancer was compared with samples from smokers without lung cancer. This allowed us to generate a diagnostic gene expression profile that could distinguish the two classes. This profile could provide additional clinical benefit in diagnosing cancer amongst smokers with suspect lung cancer. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2771
Platform:: GPL96
192 Samples

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Series

Accession:: GSE4115

ID:: 200004115

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 277112.

Large airway epithelial cells from cigarette smokers with suspect lung cancer

Analysis of large airway epithelial cells from cigarette smokers without cancer, with cancer, and with suspect lung cancer. Results provide insight into the feasibility of using gene expression to detect early stage lung cancer in smokers.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 disease state sets

Platform:: GPL96
Series:: GSE4115
192 Samples

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DataSet

Accession:: GDS2771

ID:: 2771

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20002002813.

Identification of miR-145 or miR-133a target genes in squamous cell carcinoma

(Submitter supplied) We recently identified a subset of down-regulated miRNAs such as miR-145 and miR-133a in squamous cell carcinoma. Cell growth inhibitions occurred in miR-145 and miR-133a transfectants compared with the controls, suggesting that both miRNAs function as tumor suppressors. The aims of our expression studies were identification of these miRNAs target genes.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
4 Samples

Download data: TXT

Series

Accession:: GSE20028

ID:: 200020028

Select item 20001971714.

Identification of miR-145 or miR-133a target genes in bladder cancer

(Submitter supplied) We recently identified a subset of down-regulated miRNAs such as miR-145 and miR-133a in bladder cancer. Cell growth inhibitions occurred in miR-145 and miR-133a transfectants compared with the controls, suggesting that both miRNAs function as tumor suppressors. The aims of our expression studies were identification of these miRNAs target genes.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
4 Samples

Download data: TXT

Series

Accession:: GSE19717

ID:: 200019717

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000250315.

Novel Molecular Markers for non-melanoma skin cancer

(Submitter supplied) normal skin (no), actinic keratosis (ak), and squamous cell carcinoma (scc) of the skin were examined: Carcinogenesis is a multi-step process indicated by several genes up- or down-regulated during tumor progression. The type and number of genes involved in non-melanoma skin cancer (NMSC) are still unclear. This study examined and identified different expressed genes in NMSC. Fifteen snap-frozen biopsies of five immunosuppressed organ-transplanted recipients each normal skin, actinic keratosis (AK) and invasive squamous cell carcinoma (SCC) were analysed. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2200
Platform:: GPL96
15 Samples

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Series

Accession:: GSE2503

ID:: 200002503

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 220016.

Non-melanoma skin cancer

Analysis of normal skin, actinic keratotic (AK) lesion, and squamous cell carcinoma (SCC) tumor biopsies from 5 patients with non-melanoma skin cancer (NMSC). Results provide insight into the molecular pathogenesis of NMSC.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 disease state sets

Platform:: GPL96
Series:: GSE2503
15 Samples

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DataSet

Accession:: GDS2200

ID:: 2200

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20000370817.

Expression profiling of normal lung parenchyma

(Submitter supplied) 2 normal lung parenchyma SAGE libraries, generated from 2 pools of 4 individuals each Discussed in the study: IDENTIFICATION OF NOVEL LUNG GENES IN BRONCHIAL EPITHELIUM BY SERIAL ANALYSIS OF GENE EXPRESSION Kim M. Lonergan1, Raj Chari1, Ronald J. deLeeuw1, Ashleen Shadeo1, Bryan Chi1, Ming-Sound Tsao2, Steven Jones3, Marco Marra3, Victor Ling1, Raymond Ng1,4, Calum MacAulay5, Stephen Lam5 and Wan L. more...

Organism:: Homo sapiens

Type:: Expression profiling by SAGE

Platform:: GPL4
2 Samples

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Series

Accession:: GSE3708

ID:: 200003708

PubMed Similar studies

Select item 20002354618.

Whole-genome gene expression profiles of non-tumorous human lung tissues

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10379
1349 Samples

Download data: CEL

Series

Accession:: GSE23546

ID:: 200023546

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002354519.

Whole-genome gene expression profiles of non-tumorous human lung tissues: GRNG set

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).