GEO DataSets

Analysis of liver from Lmna Gly609Gly knock-in C57BL/6 females. These mice accumulate progerin and manifest the main clinical features of human Hutchinson-Gilford progeria syndrome (HGPS). Results provide insight into the molecular mechanisms underlying HGPS.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE32609

6 Samples

Download data: CEL

Analysis of tarsal joints for up to 4 weeks following treatment with collagen to induce arthritis. Collagen induced arthritis is a model for rheumatoid arthritis. Results provide insight into the molecular events underlying the inflammation and bone remodeling that occurs in inflammatory arthritis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 5 time sets

Platform:

GPL6246

Series:

GSE61140

15 Samples

Download data: CEL

Analysis of soleus muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE70213

12 Samples

Download data: CEL

Analysis of quadriceps muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE70213

12 Samples

Download data: CEL

Analysis of spinal cord segment from interleukin (IL)-1α -/- and IL-1β -/- C57BL/6 adults 24 hrs after spinal cord injury (SCI). IL-1α and IL-1β belong to a family of cytokines playing a key role in neurodegeneration. Results provide insight into the role of IL-1α in the neuropathology of SCI.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:

GPL6246

Series:

GSE70302

12 Samples

Download data: CEL

Analysis of primary adipocytes from epididymis of C57BL/6J males fed a 60% high fat diet (HFD) for up to 7 days to induce obesity. Results provide insight into the molecular mechanisms underlying insulin resistance in adipose tissues during early obesity.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol, 3 time, 2 tissue sets

Platform:

GPL6246

Series:

GSE65557

18 Samples

Download data: CEL

Analysis of C57BL6/J primary hepatocytes depleted of either lysine acetyltransferase 2B (KAT2B) or WD repeat-containing protein 5 (WDR5) via shRNA knockdown, then stimulated with glucagon for 90 minutes. Results provide insight into the roles of KAT2B and WDR5 in hepatic gluconeogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 3 genotype/variation sets

Platform:

GPL6246

Series:

GSE47179

10 Samples

Download data: CEL, CHP

Analysis of FACS-sorted, interleukin-10 receptor (IL-10R)-deficient intestinal macrophages from 6-week-old C57BL/6 animals. IL-10 is a pleiotropic anti-inflammatory cytokine. Results provide insight into the role of IL-10 sensing by intestinal macrophages in gut homeostasis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE56444

5 Samples

Download data: CEL

Analysis of GM-CSF myeloid dendritic cells (GM-DCs) isolated from interleukin-2 (IL-2) knockouts and activated with curdlan, a pathogen-associated molecular pattern (PAMP). GM-DCs secrete cytokines such as IL-2, upon PAMP activation. Results provide insight into role of IL-2 signaling in DCs.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE58120

12 Samples

Download data: CEL

Analysis of papillary thyroid carcinoma (TPOCreER; BrafV600E) and anaplastic thyroid carcinoma (TPOCreER; BrafV600E; p53 -/-) tumors. BRAF and TP53 mutations co-occur often in ATCs, especially those with a precursor PTC. Results provide insight into the molecular basis of PTC to ATC progression.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 tissue sets

Platform:

GPL6246

Series:

GSE55933

10 Samples

Download data: CEL

Analysis of retinoblastoma (RB) ∆G/∆G mutant MEFs deprived of serum to induce quiescence. The mutant allele disrupts RB protein (pRB) interactions with the transactivation domain of E2F transcription factors. Results provide insight into pRB functions in cell cycle control independent of E2F.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:

GPL6246

Series:

GSE54924

9 Samples

Download data: CEL

Analysis of naive CD4+ T cells purified from the spleen of bHLH transcription factor Bhlhe40 knockouts, cultured in TH1, TH2 or TH17 conditions for 4 days, and stimulated with PMA and ionomycin for 4 hrs. Results provide insight into the role of Bhlhe40 in the polarized TH cell lineages.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 3 growth protocol sets

Platform:

GPL6246

Series:

GSE49166

6 Samples

Download data: CEL

Analysis of ventral midbrain (VMB) from Rev-erbα knock-outs that were entrained under a 12hr light-dark photoperiod for >10 days, kept in darkness for 2 days, and sacrificed on the third day. REV-ERBα is associated with bipolar disorder. Results provide insight into the role of REV-ERBα in VMB.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE55119

4 Samples

Download data: CEL

Analysis of male donor islets transplanted into streptozotocin-induced diabetic females then removed at pregnancy day 12.5. During pregnancy, the mother’s insulin demand increases to sustain fetal growth. Results provide insight into the molecular response of male beta cells during pregnancy.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 gender, 4 protocol, 2 tissue sets

Platform:

GPL6246

Series:

GSE59143

20 Samples

Download data: CEL

Analysis of mixed lineage leukemia (MLL)-AF9 transformed cells (MAF9) transduced with TGF-β induced factor 1 (TGIF1). TGIF1 is a member of the TALE (three-amino-acid loop extension) family of homeodomain-containing transcription factors. Results provide insight into the role of TGIF1 in MAF9 cells.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL6246

Series:

GSE55713

6 Samples

Download data: CEL

Analysis of brain dorsal cortices of E18.5 embryos deleted for Mek1 and Mek2, dual specificity kinases. Mek1 and Mek2 are components of the RAF/MEK/ERK singaling pathway. Results provide insight into the role of Mek1 and Mek2 in gliogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE40675

4 Samples

Download data: CEL, CHP

Analysis of splenocytes from WT, B6.Sle1.Sle3 (lupus mice) and B6.Sle1.Sle3 Tcf4+/− (Sle/het) mice haplodeficient for the transcription factor E2-2 (Tcf4). E2-2 is a specific regulator of plasmacytoid dendritic cell (pDC) development. Results provide insight into role of pDC in SLE pathogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 genotype/variation sets

Platform:

GPL6246

Series:

GSE57324

8 Samples

Download data: CEL

Analysis of malignant peripheral nerve sheath tumors (MPNST) from NPcis animals (carrying Nf1 and p53 mutations) treated with rapamycin, MEK inhibitor PD-0325901, or the combination of rapamycin and PD-0325901. Results provide insight into the molecular mechanisms underlying MPNST pathogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 4 protocol sets

Platform:

GPL6246

Series:

GSE57141

8 Samples

Download data: CEL

Analysis of purified Lin-c-kit+Sca1-CD16/32+ GMP cells from Cbfβ-conditional knockout mice. Runx/Cbfb heterodimers play important roles in hematopoietic cell development. Results provide insight into molecular mechanisms by which Cbfβ regulates cell fate decisions in bone marrow progenitors.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE55227

4 Samples

Download data: CEL

Analysis of purified Lin-c-kit+Sca1+ LSK cells from Cbfβ- conditional knockout mice. Runx/Cbfb heterodimers play important roles in hematopoietic cell development. Results provide insight into molecular mechanisms by which Cbfβ regulates cell fate decisions in bone marrow progenitors.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE55227

4 Samples

Download data: CEL