Core binding factor β deficiency effect on bone marrow derived-LSK hematopoietic stem cells
Summary:
Analysis of purified Lin-c-kit+Sca1+ LSK cells from Cbfβ- conditional knockout mice. Runx/Cbfb heterodimers play important roles in hematopoietic cell development. Results provide insight into molecular mechanisms by which Cbfβ regulates cell fate decisions in bone marrow progenitors.
Satpathy AT, Briseño CG, Cai X, Michael DG et al. Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder. Blood 2014 May 8;123(19):2968-77. PMID: 24677539
