Pregnancy effect on transplanted male pancreatic islets
Summary:
Analysis of male donor islets transplanted into streptozotocin-induced diabetic females then removed at pregnancy day 12.5. During pregnancy, the mother’s insulin demand increases to sustain fetal growth. Results provide insight into the molecular response of male beta cells during pregnancy.
Goyvaerts L, Lemaire K, Arijs I, Auffret J et al. Prolactin receptors and placental lactogen drive male mouse pancreatic islets to pregnancy-related mRNA changes. PLoS One 2015;10(3):e0121868. PMID: 25816302
