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Vaginal neoplasm

MedGen UID:: 22608
•Concept ID:: C0042258
•: Neoplastic Process

Synonyms:	Neoplasm, Vagina; Neoplasm, Vaginal; Neoplasms, Vagina; Neoplasms, Vaginal; Vagina Neoplasm; Vagina Neoplasms; Vaginal Neoplasm; Vaginal Neoplasms
SNOMED CT:	Neoplasm of vagina (126921000); Tumor of vagina (126921000)

HPO:	HP:0100650
Monarch Initiative:	MONDO:0021050

Definition

A tumor (abnormal growth of tissue) of the vagina. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVVaginal neoplasm

Disease
- Disorder by Site
  - Disorder of the genitourinary system
    - Reproductive system disorder
      - Female reproductive system disorder
        Female reproductive system neoplasm
        Vaginal neoplasm
        Benign vaginal neoplasm
        Benign Vaginal Melanocytic Nevus
        Vaginal Blue Nevus
        Benign vaginal mixed epithelial and mesenchymal neoplasm
        Benign vaginal mixed tumor
        Vaginal Angiomyofibroblastoma
        Vaginal Deep (Aggressive) Angiomyxoma
        Vaginal Dermoid Cyst
        Vaginal leiomyoma
        Vaginal mullerian papilloma
        Vaginal Rhabdomyoma
        Vaginal squamous papilloma
        Vaginal Superficial Myofibroblastoma
        Cervical clear cell adenocarcinoma
        Vaginal cancer
        Malignant vaginal mixed epithelial and mesenchymal neoplasm
        Malignant Vaginal Mixed Tumor Resembling Synovial Sarcoma
        Vaginal adenosarcoma
        Vaginal carcinosarcoma
        Metastatic Malignant Neoplasm in the Vagina
        Vagina sarcoma
        Vagina leiomyosarcoma
        Vaginal Low Grade Endometrioid Stromal Sarcoma
        Vaginal rhabdomyosarcoma
        Vaginal Undifferentiated Sarcoma
        Vaginal carcinoma
        Metastatic Vaginal Carcinoma
        Recurrent Vaginal Carcinoma
        Refractory Vaginal Carcinoma
        Unresectable Vaginal Carcinoma
        Vaginal adenocarcinoma
        Vaginal Adenoid Basal Carcinoma
        Vaginal adenoid cystic carcinoma
        Vaginal Adenosquamous Carcinoma
        Vaginal Cancer by AJCC v6 Stage
        Vaginal Cancer by AJCC v7 Stage
        Vaginal Cancer by AJCC v8 Stage
        Vaginal Neuroendocrine Carcinoma
        Vaginal squamous cell carcinoma
        Vaginal Undifferentiated Carcinoma
        Vaginal melanoma
        Vaginal yolk sac tumor
        Vaginal clear cell adenocarcinoma
        Vaginal Germ Cell Tumor
        Vaginal glandular neoplasm
        Vaginal adenoma
        Vaginal tubulovillous adenoma
        Vaginal villous adenoma
        Vaginal Mixed Epithelial and Mesenchymal Neoplasm
        Vaginal myxoma
        Vaginal Soft Tissue Neoplasm
        Endometrioid stromal and related neoplasms of the vagina
        Vaginal Smooth Muscle Tumor of Uncertain Malignant Potential
        Vaginal Solitary Fibrous Tumor
        Vaginal squamous tumor
        Condyloma acuminata of vagina
        Vaginal Intraepithelial Neoplasia
        High Grade Vaginal Intraepithelial Neoplasia
        Low Grade Vaginal Intraepithelial Neoplasia

Professional guidelines

PubMed

Treatment modalities for recurrent high-grade vaginal intraepithelial neoplasia.

Bogani G, Ditto A, Ferla S, Paolini B, Lombardo C, Lorusso D, Raspagliesi F
J Gynecol Oncol 2019 Mar;30(2):e20. Epub 2018 Nov 8 doi: 10.3802/jgo.2019.30.e20. PMID: 30740952 Free PMC Article

Topical imiquimod treatment for human papillomavirus infection in patients with and without cervical/vaginal intraepithelial neoplasia.

Lin CT, Qiu JT, Wang CJ, Chang SD, Tang YH, Wu PJ, Jung SM, Huang CC, Chou HH, Jao MS, Lai CH
Taiwan J Obstet Gynecol 2012 Dec;51(4):533-8. doi: 10.1016/j.tjog.2012.09.006. PMID: 23276555

See all (2)

Recent clinical studies

Etiology

Treatment modalities for recurrent high-grade vaginal intraepithelial neoplasia.

Bogani G, Ditto A, Ferla S, Paolini B, Lombardo C, Lorusso D, Raspagliesi F
J Gynecol Oncol 2019 Mar;30(2):e20. Epub 2018 Nov 8 doi: 10.3802/jgo.2019.30.e20. PMID: 30740952 Free PMC Article

Topical imiquimod treatment for human papillomavirus infection in patients with and without cervical/vaginal intraepithelial neoplasia.

Lin CT, Qiu JT, Wang CJ, Chang SD, Tang YH, Wu PJ, Jung SM, Huang CC, Chou HH, Jao MS, Lai CH
Taiwan J Obstet Gynecol 2012 Dec;51(4):533-8. doi: 10.1016/j.tjog.2012.09.006. PMID: 23276555

Risk of anal cancer in a cohort with human papillomavirus-related gynecologic neoplasm.

Saleem AM, Paulus JK, Shapter AP, Baxter NN, Roberts PL, Ricciardi R
Obstet Gynecol 2011 Mar;117(3):643-649. doi: 10.1097/AOG.0b013e31820bfb16. PMID: 21343768

See all (3)

Diagnosis

A novel technique for a rare diagnosis: MRI-guided vaginal biopsy of Skene gland adenocarcinoma: Pictorial Essay.

Dentry M, McBean R, Garrett A, Brown N
J Med Imaging Radiat Oncol 2021 Oct;65(6):724-727. Epub 2021 Jul 9 doi: 10.1111/1754-9485.13277. PMID: 34240821

Paraganglioma of the Vagina Associated With Germline SDHB Mutation: Report of a Case With Review of the Literature.

Wong RW, Liu APY, Choi CKM, Chan AOK
Int J Gynecol Pathol 2020 Nov;39(6):599-604. doi: 10.1097/PGP.0000000000000658. PMID: 31851064

Treatment modalities for recurrent high-grade vaginal intraepithelial neoplasia.

Bogani G, Ditto A, Ferla S, Paolini B, Lombardo C, Lorusso D, Raspagliesi F
J Gynecol Oncol 2019 Mar;30(2):e20. Epub 2018 Nov 8 doi: 10.3802/jgo.2019.30.e20. PMID: 30740952 Free PMC Article

Vaginal metastasis as the initial presentation of leiomyosarcoma: a case report.

Villalaín-González C, Tejerizo-García Á, Lopez-Garcia P, López-González G, Oliver-Perez MR, Jiménez-López JS
BMC Cancer 2017 Jul 26;17(1):503. doi: 10.1186/s12885-017-3484-1. PMID: 28747229 Free PMC Article

Embryonal rhabdomyosarcoma (botryoid type) of the uterine corpus and cervix in adult women: report of a case series and review of the literature.

Li RF, Gupta M, McCluggage WG, Ronnett BM
Am J Surg Pathol 2013 Mar;37(3):344-55. doi: 10.1097/PAS.0b013e31826e0271. PMID: 23348207

See all (9)

Therapy

Itraconazole treatment of primary malignant melanoma of the vagina evaluated using positron emission tomography and tissue cDNA microarray: a case report.

Inoue K, Tsubamoto H, Isono-Nakata R, Sakata K, Nakagomi N
BMC Cancer 2018 Jun 4;18(1):630. doi: 10.1186/s12885-018-4520-5. PMID: 29866134 Free PMC Article

Topical imiquimod treatment for human papillomavirus infection in patients with and without cervical/vaginal intraepithelial neoplasia.

Lin CT, Qiu JT, Wang CJ, Chang SD, Tang YH, Wu PJ, Jung SM, Huang CC, Chou HH, Jao MS, Lai CH
Taiwan J Obstet Gynecol 2012 Dec;51(4):533-8. doi: 10.1016/j.tjog.2012.09.006. PMID: 23276555

Aggressive clinical course of primary invasive vaginal carcinoma associated with type 61 HPV: a case report.

Zanfagnin V, Tripodi E, Perotto S, Ravarino N, Zola P
Tumori 2012 Mar-Apr;98(2):57e-58e. doi: 10.1700/1088.11951. PMID: 22678006

Risk of anal cancer in a cohort with human papillomavirus-related gynecologic neoplasm.

Saleem AM, Paulus JK, Shapter AP, Baxter NN, Roberts PL, Ricciardi R
Obstet Gynecol 2011 Mar;117(3):643-649. doi: 10.1097/AOG.0b013e31820bfb16. PMID: 21343768

See all (4)

Prognosis

Treatment modalities for recurrent high-grade vaginal intraepithelial neoplasia.

Bogani G, Ditto A, Ferla S, Paolini B, Lombardo C, Lorusso D, Raspagliesi F
J Gynecol Oncol 2019 Mar;30(2):e20. Epub 2018 Nov 8 doi: 10.3802/jgo.2019.30.e20. PMID: 30740952 Free PMC Article

Itraconazole treatment of primary malignant melanoma of the vagina evaluated using positron emission tomography and tissue cDNA microarray: a case report.

Inoue K, Tsubamoto H, Isono-Nakata R, Sakata K, Nakagomi N
BMC Cancer 2018 Jun 4;18(1):630. doi: 10.1186/s12885-018-4520-5. PMID: 29866134 Free PMC Article

Vaginal metastasis as the initial presentation of leiomyosarcoma: a case report.

Aggressive clinical course of primary invasive vaginal carcinoma associated with type 61 HPV: a case report.

Zanfagnin V, Tripodi E, Perotto S, Ravarino N, Zola P
Tumori 2012 Mar-Apr;98(2):57e-58e. doi: 10.1700/1088.11951. PMID: 22678006

See all (4)

Clinical prediction guides

Treatment modalities for recurrent high-grade vaginal intraepithelial neoplasia.

Bogani G, Ditto A, Ferla S, Paolini B, Lombardo C, Lorusso D, Raspagliesi F
J Gynecol Oncol 2019 Mar;30(2):e20. Epub 2018 Nov 8 doi: 10.3802/jgo.2019.30.e20. PMID: 30740952 Free PMC Article

Topical imiquimod treatment for human papillomavirus infection in patients with and without cervical/vaginal intraepithelial neoplasia.

Lin CT, Qiu JT, Wang CJ, Chang SD, Tang YH, Wu PJ, Jung SM, Huang CC, Chou HH, Jao MS, Lai CH
Taiwan J Obstet Gynecol 2012 Dec;51(4):533-8. doi: 10.1016/j.tjog.2012.09.006. PMID: 23276555

Risk of anal cancer in a cohort with human papillomavirus-related gynecologic neoplasm.

Saleem AM, Paulus JK, Shapter AP, Baxter NN, Roberts PL, Ricciardi R
Obstet Gynecol 2011 Mar;117(3):643-649. doi: 10.1097/AOG.0b013e31820bfb16. PMID: 21343768

Adenocarcinoma of the vagina in a patient with gonadal dysgenesis.

Shingleton HM, Younger JB, Beasley WE, Levy D, Gore H, Lawrence WD
Obstet Gynecol 1979 Mar;53(3 Suppl):92S-97S. PMID: 424140

See all (4)

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Vaginal neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

Practice guidelines

Consumer resources

Reviews

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