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Dermatitis

MedGen UID:
4233
•Concept ID:
C0011603
•
Disease or Syndrome
Synonym: Dermatitides
SNOMED CT: Dermatitis (703938007)

Definition

An inflammatory process affecting the skin. Signs include red rash, itching, and blister formation. Representative examples are contact dermatitis, atopic dermatitis, and seborrheic dermatitis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDermatitis

Professional guidelines

PubMed

International consensus statement on allergy and rhinology: Allergic rhinitis - 2023.
Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, Luong A, Rodriguez K, Sedaghat AR, Toskala E, Villwock J, Abdullah B, Akdis C, Alt JA, Ansotegui IJ, Azar A, Baroody F, Benninger MS, Bernstein J, Brook C, Campbell R, Casale T, Chaaban MR, Chew FT, Chambliss J, Cianferoni A, Custovic A, Davis EM, DelGaudio JM, Ellis AK, Flanagan C, Fokkens WJ, Franzese C, Greenhawt M, Gill A, Halderman A, Hohlfeld JM, Incorvaia C, Joe SA, Joshi S, Kuruvilla ME, Kim J, Klein AM, Krouse HJ, Kuan EC, Lang D, Larenas-Linnemann D, Laury AM, Lechner M, Lee SE, Lee VS, Loftus P, Marcus S, Marzouk H, Mattos J, McCoul E, Melen E, Mims JW, Mullol J, Nayak JV, Oppenheimer J, Orlandi RR, Phillips K, Platt M, Ramanathan M Jr, Raymond M, Rhee CS, Reitsma S, Ryan M, Sastre J, Schlosser RJ, Schuman TA, Shaker MS, Sheikh A, Smith KA, Soyka MB, Takashima M, Tang M, Tantilipikorn P, Taw MB, Tversky J, Tyler MA, Veling MC, Wallace D, Wang Y, White A, Zhang L
Int Forum Allergy Rhinol 2023 Apr;13(4):293-859. Epub 2023 Mar 6 doi: 10.1002/alr.23090. PMID: 36878860
Scabies: Epidemiology, Diagnosis, and Treatment.
Sunderkötter C, Wohlrab J, Hamm H
Dtsch Arztebl Int 2021 Oct 15;118(41):695-704. doi: 10.3238/arztebl.m2021.0296. PMID: 34615594Free PMC Article
Atopic Dermatitis: Diagnosis and Treatment.
Frazier W, Bhardwaj N
Am Fam Physician 2020 May 15;101(10):590-598. PMID: 32412211

Recent clinical studies

Etiology

Phytotherapy in paediatric skin disorders - A systematic literature review.
Kloter E, Albanese F, Schweighoffer R, Wolf U
Complement Ther Med 2023 Jun;74:102942. Epub 2023 Mar 21 doi: 10.1016/j.ctim.2023.102942. PMID: 36958415
Atopic dermatitis endotypes: knowledge for personalized medicine.
Kim J, Ahn K
Curr Opin Allergy Clin Immunol 2022 Jun 1;22(3):153-159. Epub 2022 Feb 11 doi: 10.1097/ACI.0000000000000820. PMID: 35152229
From Emollients to Biologicals: Targeting Atopic Dermatitis.
Salvati L, Cosmi L, Annunziato F
Int J Mol Sci 2021 Sep 26;22(19) doi: 10.3390/ijms221910381. PMID: 34638722Free PMC Article
Irritant Contact Dermatitis.
Bains SN, Nash P, Fonacier L
Clin Rev Allergy Immunol 2019 Feb;56(1):99-109. doi: 10.1007/s12016-018-8713-0. PMID: 30293200
Common spongiotic dermatoses.
Gru AA, Salavaggione AL
Semin Diagn Pathol 2017 May;34(3):226-236. Epub 2017 Feb 10 doi: 10.1053/j.semdp.2017.02.002. PMID: 28237387

Diagnosis

Plant Dermatitis.
Diedrich V, Zweerink K, Elder B
Emerg Med Clin North Am 2024 Aug;42(3):613-638. Epub 2024 May 23 doi: 10.1016/j.emc.2024.03.001. PMID: 38925778
Contact Dermatitis: Classifications and Management.
Li Y, Li L
Clin Rev Allergy Immunol 2021 Dec;61(3):245-281. Epub 2021 Jul 15 doi: 10.1007/s12016-021-08875-0. PMID: 34264448
Mimics of Dermatitis.
Bailiff OA, Mowad CM
Immunol Allergy Clin North Am 2021 Aug;41(3):493-515. doi: 10.1016/j.iac.2021.04.009. PMID: 34225903
Common spongiotic dermatoses.
Gru AA, Salavaggione AL
Semin Diagn Pathol 2017 May;34(3):226-236. Epub 2017 Feb 10 doi: 10.1053/j.semdp.2017.02.002. PMID: 28237387
Perioral dermatitis.
Lipozenčić J, Hadžavdić SL
Clin Dermatol 2014 Jan-Feb;32(1):125-30. doi: 10.1016/j.clindermatol.2013.05.034. PMID: 24314386

Therapy

Systemic treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.
Chu AWL, Wong MM, Rayner DG, Guyatt GH, Díaz Martinez JP, Ceccacci R, Zhao IX, McMullen E, Srivastava A, Wang J, Wen A, Wang FC, Brignardello-Petersen R, Izcovich A, Oykhman P, Wheeler KE, Wang J, Spergel JM, Singh JA, Silverberg JI, Ong PY, O'Brien M, Martin SA, Lio PA, Lind ML, LeBovidge J, Kim E, Huynh J, Greenhawt M, Gardner DD, Frazier WT, Ellison K, Chen L, Capozza K, De Benedetto A, Boguniewicz M, Smith Begolka W, Asiniwasis RN, Schneider LC, Chu DK
J Allergy Clin Immunol 2023 Dec;152(6):1470-1492. Epub 2023 Sep 9 doi: 10.1016/j.jaci.2023.08.029. PMID: 37678577
Efficacy and Safety of Upadacitinib in Patients With Moderate to Severe Atopic Dermatitis: Analysis of Follow-up Data From the Measure Up 1 and Measure Up 2 Randomized Clinical Trials.
Simpson EL, Papp KA, Blauvelt A, Chu CY, Hong HC, Katoh N, Calimlim BM, Thyssen JP, Chiou AS, Bissonnette R, Stein Gold LF, Wegzyn C, Hu X, Liu M, Liu J, Tenorio AR, Chu AD, Guttman-Yassky E
JAMA Dermatol 2022 Apr 1;158(4):404-413. doi: 10.1001/jamadermatol.2022.0029. PMID: 35262646Free PMC Article
Topical finasteride for male and female pattern hair loss: Is it a safe and effective alternative?
Gupta AK, Talukder M
J Cosmet Dermatol 2022 May;21(5):1841-1848. Epub 2022 Mar 14 doi: 10.1111/jocd.14895. PMID: 35238144
Role of nutritional supplements in selected dermatological disorders: A review.
Sardana K, Sachdeva S
J Cosmet Dermatol 2022 Jan;21(1):85-98. Epub 2021 Sep 26 doi: 10.1111/jocd.14436. PMID: 34564936
Systematic review of treatments for atopic eczema.
Hoare C, Li Wan Po A, Williams H
Health Technol Assess 2000;4(37):1-191. PMID: 11134919Free PMC Article

Prognosis

Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study.
Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, Lu Q
Br J Dermatol 2023 Dec 20;190(1):55-61. doi: 10.1093/bjd/ljad339. PMID: 37705227
Erythroderma (exfoliative dermatitis). Part 1: underlying causes, clinical presentation and pathogenesis.
Tso S, Satchwell F, Moiz H, Hari T, Dhariwal S, Barlow R, Forbat E, Randeva H, Tan YT, Ilchyshyn A, Kwok MM, Barber TM, Thind C, Tso ACY
Clin Exp Dermatol 2021 Aug;46(6):1001-1010. Epub 2021 May 1 doi: 10.1111/ced.14625. PMID: 33639006
The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990-2017.
Laughter MR, Maymone MBC, Mashayekhi S, Arents BWM, Karimkhani C, Langan SM, Dellavalle RP, Flohr C
Br J Dermatol 2021 Feb;184(2):304-309. Epub 2020 Nov 29 doi: 10.1111/bjd.19580. PMID: 33006135
Atopic dermatitis.
Mounsey SJ, Agius E
Br J Hosp Med (Lond) 2017 Dec 2;78(12):C183-C187. doi: 10.12968/hmed.2017.78.12.C183. PMID: 29240493
Diagnosis and management of contact dermatitis.
Usatine RP, Riojas M
Am Fam Physician 2010 Aug 1;82(3):249-55. PMID: 20672788

Clinical prediction guides

Counting the Burden: Atopic Dermatitis and Health-related Quality of Life.
Ali F, Vyas J, Finlay AY
Acta Derm Venereol 2020 Jun 9;100(12):adv00161. doi: 10.2340/00015555-3511. PMID: 32412644Free PMC Article
The Validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD): The development and reliability testing of a novel clinical outcome measurement instrument for the severity of atopic dermatitis.
Simpson E, Bissonnette R, Eichenfield LF, Guttman-Yassky E, King B, Silverberg JI, Beck LA, Bieber T, Reich K, Kabashima K, Seyger M, Siegfried E, Stingl G, Feldman SR, Menter A, van de Kerkhof P, Yosipovitch G, Paul C, Martel P, Dubost-Brama A, Armstrong J, Chavda R, Frey S, Joubert Y, Milutinovic M, Parneix A, Teixeira HD, Lin CY, Sun L, Klekotka P, Nickoloff B, Dutronc Y, Mallbris L, Janes JM, DeLozier AM, Nunes FP, Paller AS
J Am Acad Dermatol 2020 Sep;83(3):839-846. Epub 2020 Apr 25 doi: 10.1016/j.jaad.2020.04.104. PMID: 32344071
European S2k Guideline on Chronic Pruritus.
Weisshaar E, Szepietowski JC, Dalgard FJ, Garcovich S, Gieler U, Giménez-Arnau AM, Lambert J, Leslie T, Mettang T, Misery L, Şavk E, Streit M, Tschachler E, Wallengren J, Ständer S
Acta Derm Venereol 2019 Apr 1;99(5):469-506. doi: 10.2340/00015555-3164. PMID: 30931482
The grenz zone.
Abbas O, Mahalingam M
Am J Dermatopathol 2013 Feb;35(1):83-91. doi: 10.1097/DAD.0b013e31824feb4e. PMID: 23348142
Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis.
Dermatology 1993;186(1):23-31. doi: 10.1159/000247298. PMID: 8435513

Recent systematic reviews

Dupilumab in Inflammatory Skin Diseases: A Systematic Review.
Olbrich H, Sadik CD, Ludwig RJ, Thaçi D, Boch K
Biomolecules 2023 Mar 31;13(4) doi: 10.3390/biom13040634. PMID: 37189381Free PMC Article
Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis.
Drucker AM, Morra DE, Prieto-Merino D, Ellis AG, Yiu ZZN, Rochwerg B, Di Giorgio S, Arents BWM, Burton T, Spuls PI, Schmitt J, Flohr C
JAMA Dermatol 2022 May 1;158(5):523-532. doi: 10.1001/jamadermatol.2022.0455. PMID: 35293977Free PMC Article
Perioral dermatitis: Diagnosis, proposed etiologies, and management.
Searle T, Ali FR, Al-Niaimi F
J Cosmet Dermatol 2021 Dec;20(12):3839-3848. Epub 2021 Mar 16 doi: 10.1111/jocd.14060. PMID: 33751778
Prevalence and Incidence of Atopic Dermatitis: A Systematic Review.
Bylund S, Kobyletzki LB, Svalstedt M, Svensson Å
Acta Derm Venereol 2020 Jun 9;100(12):adv00160. doi: 10.2340/00015555-3510. PMID: 32412646Free PMC Article
Evidence-Based Skin Care: A Systematic Literature Review and the Development of a Basic Skin Care Algorithm.
Lichterfeld A, Hauss A, Surber C, Peters T, Blume-Peytavi U, Kottner J
J Wound Ostomy Continence Nurs 2015 Sep-Oct;42(5):501-24. doi: 10.1097/WON.0000000000000162. PMID: 26165590

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