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Phototoxic dermatitis

MedGen UID:
58188
•Concept ID:
C0162830
•
Disease or Syndrome
Synonyms: Contact Dermatitides, Phototoxic; Contact Dermatitis, Phototoxic; Dermatitides, Phototoxic; Dermatitides, Phototoxic Contact; Dermatitis, Contact, Phototoxic; Dermatitis, Phototoxic; Dermatitis, Phototoxic Contact; Phototoxic Contact Dermatitides; Phototoxic Contact Dermatitis; Phototoxic Dermatitides; Phototoxic Dermatitis
SNOMED CT: Photosensitization reaction (84326006); Phototoxic eczema (53597009); Phototoxic reaction (53597009); Photosensitive dermatitis (84326006); Phototoxic dermatitis (53597009)
 
Monarch Initiative: MONDO:0006598

Definition

Dermatitis caused or precipitated by exposure to ultraviolet sunlight, or by mediating phototoxic or photoallergic material in response to ultraviolet sunlight. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPhototoxic dermatitis

Professional guidelines

PubMed

Evidence-based consensus guidelines for the diagnosis and management of erythropoietic protoporphyria and X-linked protoporphyria.
Dickey AK, Naik H, Keel SB, Levy C, Beaven SW, Elmariah SB, Erwin AL, Goddu RJ, Hedstrom K, Leaf RK, Kazamel M, Mazepa M, Philpotts LL, Quigley J, Raef H, Rudnick SR, Saberi B, Thapar M, Ungar J, Wang B, Balwani M; Porphyrias Consortium of the Rare Diseases Clinical Research Network
J Am Acad Dermatol 2023 Dec;89(6):1227-1237. Epub 2022 Aug 27 doi: 10.1016/j.jaad.2022.08.036. PMID: 36041558Free PMC Article
Laser-Assisted Photodynamic Therapy: Two Novel Protocols for Enhanced Treatment Results.
Stevenson ML, Karen JK, Hale EK
J Drugs Dermatol 2017 Apr 1;16(4):329-331. PMID: 28403266
Treatment of the cutaneous porphyrias.
Mathews-Roth MM
Clin Dermatol 1998 Mar-Apr;16(2):295-8. doi: 10.1016/s0738-081x(97)00208-3. PMID: 9554241

Recent clinical studies

Etiology

Photodermatoses in skin of colour.
Gutierrez D, Gaulding JV, Motta Beltran AF, Lim HW, Pritchett EN
J Eur Acad Dermatol Venereol 2018 Nov;32(11):1879-1886. Epub 2018 Jul 15 doi: 10.1111/jdv.15115. PMID: 29888465
Voriconazole-associated phototoxic dermatoses and skin cancer.
Goyal RK
Expert Rev Anti Infect Ther 2015;13(12):1537-46. Epub 2015 Oct 21 doi: 10.1586/14787210.2015.1102053. PMID: 26488688
Fragrance material review on 2,6-dimethyl-4-heptanol.
McGinty D, Scognamiglio J, Letizia CS, Api AM
Food Chem Toxicol 2010 Jul;48 Suppl 4:S89-92. doi: 10.1016/j.fct.2010.05.037. PMID: 20659645
Fragrance material review on 4-methyl-2-pentanol.
McGinty D, Scognamiglio J, Letizia CS, Api AM
Food Chem Toxicol 2010 Jul;48 Suppl 4:S55-9. doi: 10.1016/j.fct.2010.05.028. PMID: 20659636
Coal tar in dermatology.
Roelofzen JH, Aben KK, van der Valk PG, van Houtum JL, van de Kerkhof PC, Kiemeney LA
J Dermatolog Treat 2007;18(6):329-34. doi: 10.1080/09546630701496347. PMID: 17852640

Diagnosis

Lime Dermatitis.
Belcadi J, Oulad Ali S, Senouci K
Dermatitis 2024 Sep-Oct;35(5):429-430. Epub 2024 Feb 22 doi: 10.1089/derm.2024.0017. PMID: 38387001
Psoralen-Induced Phytophotodermatitis.
Ellis CR, Elston DM
Dermatitis 2021 May-Jun 01;32(3):140-143. doi: 10.1097/DER.0000000000000691. PMID: 33273237
Phototoxicity revisited.
Nat Methods 2018 Oct;15(10):751. doi: 10.1038/s41592-018-0170-4. PMID: 30275585
Phytophotodermatitis.
Marcos LA, Kahler R
Int J Infect Dis 2015 Sep;38:7-8. Epub 2015 Jul 9 doi: 10.1016/j.ijid.2015.07.004. PMID: 26166698
Phytophotodermatitis.
Moreau JF, English JC 3rd, Gehris RP
J Pediatr Adolesc Gynecol 2014 Apr;27(2):93-4. doi: 10.1016/j.jpag.2013.11.001. PMID: 24745072

Therapy

Lime Dermatitis.
Belcadi J, Oulad Ali S, Senouci K
Dermatitis 2024 Sep-Oct;35(5):429-430. Epub 2024 Feb 22 doi: 10.1089/derm.2024.0017. PMID: 38387001
Psoralen-Induced Phytophotodermatitis.
Ellis CR, Elston DM
Dermatitis 2021 May-Jun 01;32(3):140-143. doi: 10.1097/DER.0000000000000691. PMID: 33273237
Phytophotodermatitis.
Marcos LA, Kahler R
Int J Infect Dis 2015 Sep;38:7-8. Epub 2015 Jul 9 doi: 10.1016/j.ijid.2015.07.004. PMID: 26166698
Cutaneous adverse reactions of amiodarone.
Jaworski K, Walecka I, Rudnicka L, Gnatowski M, Kosior DA
Med Sci Monit 2014 Nov 21;20:2369-72. doi: 10.12659/MSM.890881. PMID: 25413691Free PMC Article
Phytophotodermatitis.
Moreau JF, English JC 3rd, Gehris RP
J Pediatr Adolesc Gynecol 2014 Apr;27(2):93-4. doi: 10.1016/j.jpag.2013.11.001. PMID: 24745072

Prognosis

Photodermatoses in skin of colour.
Gutierrez D, Gaulding JV, Motta Beltran AF, Lim HW, Pritchett EN
J Eur Acad Dermatol Venereol 2018 Nov;32(11):1879-1886. Epub 2018 Jul 15 doi: 10.1111/jdv.15115. PMID: 29888465
Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments.
Onoue S, Seto Y, Sato H, Nishida H, Hirota M, Ashikaga T, Api AM, Basketter D, Tokura Y
J Dermatol Sci 2017 Jan;85(1):4-11. Epub 2016 Aug 6 doi: 10.1016/j.jdermsci.2016.08.005. PMID: 27528585
Molecular mechanisms of drug photodegradation and photosensitization.
Zaheer MR, Gupta A, Iqbal J, Zia Q, Ahmad A, Roohi, Owais M, Hashlamon A, Mohd Setapar SH, Ashraf GM, Aliev G
Curr Pharm Des 2016;22(7):768-82. doi: 10.2174/1381612822666151209151408. PMID: 26675230
Photosensitive disorders of the skin with ocular involvement.
Rambhatla PV, Brescoll J, Hwang F, Juzych M, Lim HW
Clin Dermatol 2015 Mar-Apr;33(2):238-46. doi: 10.1016/j.clindermatol.2014.10.016. PMID: 25704944
Update on photodermatoses.
Santoro FA, Lim HW
Semin Cutan Med Surg 2011 Dec;30(4):229-38. doi: 10.1016/j.sder.2011.07.007. PMID: 22123421

Clinical prediction guides

Evaluation of phototoxicity induced by the anticancer drug rucaparib.
Mateos-Pujante A, Jiménez MC, Andreu I
Sci Rep 2022 Mar 2;12(1):3434. doi: 10.1038/s41598-022-07319-9. PMID: 35236893Free PMC Article
RIFM fragrance ingredient safety assessment, 6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-propionaldehyde, CAS Registry Number 33885-51-7.
Api AM, Belsito D, Botelho D, Bruze M, Burton GA Jr, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y
Food Chem Toxicol 2022 Jan 15;159 Suppl 1:112658. Epub 2021 Nov 4 doi: 10.1016/j.fct.2021.112658. PMID: 34742791
The influence of microemulsion structure on their skin irritation and phototoxicity potential.
Rozman B, Gosenca M, Falson F, Gašperlin M
Int J Pharm 2016 Feb 29;499(1-2):228-235. Epub 2016 Jan 3 doi: 10.1016/j.ijpharm.2015.12.064. PMID: 26757147
Development of novel in vitro photosafety assays focused on the Keap1-Nrf2-ARE pathway.
Tsujita-Inoue K, Hirota M, Atobe T, Ashikaga T, Tokura Y, Kouzuki H
J Appl Toxicol 2016 Jul;36(7):956-68. Epub 2015 Oct 28 doi: 10.1002/jat.3234. PMID: 26511905
Alternative methods for eye and skin irritation tests: an overview.
Vinardell MP, Mitjans M
J Pharm Sci 2008 Jan;97(1):46-59. doi: 10.1002/jps.21088. PMID: 17701961

Recent systematic reviews

Drug-induced phototoxicity: A systematic review.
Kim WB, Shelley AJ, Novice K, Joo J, Lim HW, Glassman SJ
J Am Acad Dermatol 2018 Dec;79(6):1069-1075. Epub 2018 Jul 10 doi: 10.1016/j.jaad.2018.06.061. PMID: 30003982
Third and fourth generation fluoroquinolone antibacterials: a systematic review of safety and toxicity profiles.
Sousa J, Alves G, Fortuna A, Falcão A
Curr Drug Saf 2014;9(2):89-105. doi: 10.2174/1574886308666140106154754. PMID: 24410307

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