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Vibratory urticaria(VBU)

MedGen UID:
510413
•Concept ID:
C0157743
•
Disease or Syndrome
Synonym: VBU
SNOMED CT: Vibratory urticaria (51247001)
 
Gene (location): ADGRE2 (19p13.12)
 
HPO: HP:0410138
Monarch Initiative: MONDO:0006618
OMIM®: 125630

Definition

Autosomal dominant vibratory urticaria is characterized by localized hives and systemic manifestations in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum (Boyden et al., 2016). [from OMIM]

Clinical features

From HPO
Flushing
MedGen UID:
5234
•Concept ID:
C0016382
•
Sign or Symptom
Recurrent episodes of redness of the skin together with a sensation of warmth or burning of the affected areas of skin.
See: Feature record | Search on this feature
Urticaria
MedGen UID:
22587
•Concept ID:
C0042109
•
Disease or Syndrome
Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intensely pruritic, and blanches completely with pressure.
See: Feature record | Search on this feature
Facial erythema
MedGen UID:
65986
•Concept ID:
C0239488
•
Finding
Redness of the skin of the face, caused by hyperemia of the capillaries in the lower layers of the skin.
See: Feature record | Search on this feature
Dermatographic urticaria
MedGen UID:
488854
•Concept ID:
C0343065
•
Disease or Syndrome
An exaggerated whealing tendency when the skin is stroked, that is, formation of red, itchy bumps and lines on the skin as a result of pressure on the skin (for instance, stroking the skin with a pen or tongue depressor).
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVibratory urticaria

Professional guidelines

PubMed

Vibratory Angioedema Subgroups, Features, and Treatment: Results of a Systematic Review.
Kulthanan K, Ungprasert P, Tapechum S, Rujitharanawong C, Kiratiwongwan R, Munprom K, Terhorst-Molawi D, Maurer M
J Allergy Clin Immunol Pract 2021 Feb;9(2):971-984. Epub 2020 Sep 19 doi: 10.1016/j.jaip.2020.09.009. PMID: 32961312
Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence.
Maurer M, Metz M, Brehler R, Hillen U, Jakob T, Mahler V, Pföhler C, Staubach P, Treudler R, Wedi B, Magerl M
J Allergy Clin Immunol 2018 Feb;141(2):638-649. Epub 2017 Jul 24 doi: 10.1016/j.jaci.2017.06.032. PMID: 28751232

Recent clinical studies

Etiology

How to Approach Chronic Inducible Urticaria.
Maurer M, Fluhr JW, Khan DA
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1119-1130. doi: 10.1016/j.jaip.2018.03.007. PMID: 30033913

Diagnosis

Vibratory Angioedema Subgroups, Features, and Treatment: Results of a Systematic Review.
Kulthanan K, Ungprasert P, Tapechum S, Rujitharanawong C, Kiratiwongwan R, Munprom K, Terhorst-Molawi D, Maurer M
J Allergy Clin Immunol Pract 2021 Feb;9(2):971-984. Epub 2020 Sep 19 doi: 10.1016/j.jaip.2020.09.009. PMID: 32961312
Chronic inducible urticaria: classification and prominent features of physical and non-physical types.
Pozderac I, Lugović-Mihić L, Artuković M, Stipić-Marković A, Kuna M, Ferček I
Acta Dermatovenerol Alp Pannonica Adriat 2020 Sep;29(3):141-148. PMID: 32975301
Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2.
Naranjo AN, Bandara G, Bai Y, Smelkinson MG, Tobío A, Komarow HD, Boyden SE, Kastner DL, Metcalfe DD, Olivera A
J Invest Dermatol 2020 Nov;140(11):2210-2220.e5. Epub 2020 Mar 25 doi: 10.1016/j.jid.2020.03.936. PMID: 32222457Free PMC Article
How to Approach Chronic Inducible Urticaria.
Maurer M, Fluhr JW, Khan DA
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1119-1130. doi: 10.1016/j.jaip.2018.03.007. PMID: 30033913
Physical urticarias and cholinergic urticaria.
Abajian M, Schoepke N, Altrichter S, Zuberbier T, Maurer M
Immunol Allergy Clin North Am 2014 Feb;34(1):73-88. Epub 2013 Oct 28 doi: 10.1016/j.iac.2013.09.010. PMID: 24262690

Therapy

Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2.
Naranjo AN, Bandara G, Bai Y, Smelkinson MG, Tobío A, Komarow HD, Boyden SE, Kastner DL, Metcalfe DD, Olivera A
J Invest Dermatol 2020 Nov;140(11):2210-2220.e5. Epub 2020 Mar 25 doi: 10.1016/j.jid.2020.03.936. PMID: 32222457Free PMC Article
Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia.
Le QT, Lyons JJ, Naranjo AN, Olivera A, Lazarus RA, Metcalfe DD, Milner JD, Schwartz LB
J Exp Med 2019 Oct 7;216(10):2348-2361. Epub 2019 Jul 23 doi: 10.1084/jem.20190701. PMID: 31337736Free PMC Article
Vibratory Urticaria Associated with a Missense Variant in ADGRE2.
Boyden SE, Desai A, Cruse G, Young ML, Bolan HC, Scott LM, Eisch AR, Long RD, Lee CC, Satorius CL, Pakstis AJ, Olivera A, Mullikin JC, Chouery E, Mégarbané A, Medlej-Hashim M, Kidd KK, Kastner DL, Metcalfe DD, Komarow HD
N Engl J Med 2016 Feb 18;374(7):656-63. Epub 2016 Feb 3 doi: 10.1056/NEJMoa1500611. PMID: 26841242Free PMC Article

Prognosis

Vibratory Urticaria Associated with a Missense Variant in ADGRE2.
Boyden SE, Desai A, Cruse G, Young ML, Bolan HC, Scott LM, Eisch AR, Long RD, Lee CC, Satorius CL, Pakstis AJ, Olivera A, Mullikin JC, Chouery E, Mégarbané A, Medlej-Hashim M, Kidd KK, Kastner DL, Metcalfe DD, Komarow HD
N Engl J Med 2016 Feb 18;374(7):656-63. Epub 2016 Feb 3 doi: 10.1056/NEJMoa1500611. PMID: 26841242Free PMC Article

Clinical prediction guides

Acquired vibratory angioedema with a severe impact on work performance.
Gatica-Ortega ME, Sánchez-Matas I, Sánchez-Muñoz L, Pastor-Nieto MA
Occup Med (Lond) 2022 Dec 7;72(8):566-569. doi: 10.1093/occmed/kqac092. PMID: 36130167
Vibratory Urticaria Associated with a Missense Variant in ADGRE2.
Boyden SE, Desai A, Cruse G, Young ML, Bolan HC, Scott LM, Eisch AR, Long RD, Lee CC, Satorius CL, Pakstis AJ, Olivera A, Mullikin JC, Chouery E, Mégarbané A, Medlej-Hashim M, Kidd KK, Kastner DL, Metcalfe DD, Komarow HD
N Engl J Med 2016 Feb 18;374(7):656-63. Epub 2016 Feb 3 doi: 10.1056/NEJMoa1500611. PMID: 26841242Free PMC Article

Recent systematic reviews

Vibratory Angioedema Subgroups, Features, and Treatment: Results of a Systematic Review.
Kulthanan K, Ungprasert P, Tapechum S, Rujitharanawong C, Kiratiwongwan R, Munprom K, Terhorst-Molawi D, Maurer M
J Allergy Clin Immunol Pract 2021 Feb;9(2):971-984. Epub 2020 Sep 19 doi: 10.1016/j.jaip.2020.09.009. PMID: 32961312

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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