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Dermatosis papulosa nigra

MedGen UID:
4238
•Concept ID:
C0011645
•
Disease or Syndrome
Synonym: Dermatosis Papulosa Nigra
SNOMED CT: Dermatosis papulosa nigra (103672009); Dermatosis papulosa nigra (254669003)
 
Monarch Initiative: MONDO:0007446
OMIM®: 125600

Definition

A benign skin condition commonly seen in dark-skinned individuals that is characterized by multiple small hyperpigmented papular lesions resembling seborrheic keratosis on the face and upper body. [from NCI]

Clinical features

From HPO
Abnormality of the skin
MedGen UID:
1845238
•Concept ID:
C5848159
•
Anatomical Abnormality
An abnormality of the skin.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDermatosis papulosa nigra

Professional guidelines

PubMed

A Systematic Review on the Treatment of Dermatosis Papulosa Nigra.
Maghfour J, Ogunleye T
J Drugs Dermatol 2021 Apr 1;20(4):467-472. doi: 10.36849/JDD.2021.5555. PMID: 33852246
Elective Treatment of Dermatosis Papulosa Nigra: A Review of Treatment Modalities.
Tran M, Richer V
Skin Therapy Lett 2020 Sep;25(4):1-5. PMID: 33017107
What's new in objective assessment and treatment of facial hyperpigmentation?
Molinar VE, Taylor SC, Pandya AG
Dermatol Clin 2014 Apr;32(2):123-35. doi: 10.1016/j.det.2013.12.008. PMID: 24679999

Recent clinical studies

Etiology

Elective Treatment of Dermatosis Papulosa Nigra: A Review of Treatment Modalities.
Tran M, Richer V
Skin Therapy Lett 2020 Sep;25(4):1-5. PMID: 33017107
Carbon dioxide laser ablation of dermatosis papulosa nigra: high satisfaction and few complications in patients with pigmented skin.
Ali FR, Bakkour W, Ferguson JE, Madan V
Lasers Med Sci 2016 Apr;31(3):593-5. Epub 2016 Feb 11 doi: 10.1007/s10103-016-1906-y. PMID: 26868030
Dermatosis Papulosa Nigra and 10,600-nm CO2 laser, a good choice.
Bruscino N, Conti R, Campolmi P, Bonan P, Cannarozzo G, Lazzeri L, Moretti S
J Cosmet Laser Ther 2014 Jun;16(3):114-6. Epub 2013 Nov 18 doi: 10.3109/14764172.2013.854640. PMID: 24131098
FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra.
Hafner C, Landthaler M, Mentzel T, Vogt T
Br J Dermatol 2010 Mar;162(3):508-12. Epub 2009 Sep 1 doi: 10.1111/j.1365-2133.2009.09488.x. PMID: 19845664
Dermatosis papulosa nigra in Dakar, Senegal.
Niang SO, Kane A, Diallo M, Choutah F, Dieng MT, Ndiaye B
Int J Dermatol 2007 Oct;46 Suppl 1:45-7. doi: 10.1111/j.1365-4632.2007.03465.x. PMID: 17919208

Diagnosis

Common Dermatologic Conditions in Skin of Color.
Frazier WT, Proddutur S, Swope K
Am Fam Physician 2023 Jan;107(1):26-34. PMID: 36689965
Superimposed segmental dermatosis papulosa nigra.
Grimalt R, Happle R
Clin Exp Dermatol 2020 Jun;45(4):521-523. Epub 2019 Oct 22 doi: 10.1111/ced.14121. PMID: 31642076
Recent advances in managing and understanding seborrheic keratosis.
Wollina U
F1000Res 2019;8 Epub 2019 Aug 28 doi: 10.12688/f1000research.18983.1. PMID: 31508199Free PMC Article
Dermatosis papulosa nigra: a clinically and histopathologically distinct entity.
Metin SA, Lee BW, Lambert WC, Parish LC
Clin Dermatol 2017 Sep-Oct;35(5):491-496. Epub 2017 Jun 8 doi: 10.1016/j.clindermatol.2017.06.001. PMID: 28916031
Acquired hyperpigmentations.
Cestari TF, Dantas LP, Boza JC
An Bras Dermatol 2014 Jan-Feb;89(1):11-25. doi: 10.1590/abd1806-4841.20142353. PMID: 24626644Free PMC Article

Therapy

Photodynamic therapy for facial dermatosis papulosa nigra: Efficacy and safety in a preliminary study.
Huang Z, Wang F, Liu D, Zhang R
Photodiagnosis Photodyn Ther 2024 Aug;48:104273. Epub 2024 Jul 11 doi: 10.1016/j.pdpdt.2024.104273. PMID: 39002830
A Systematic Review on the Treatment of Dermatosis Papulosa Nigra.
Maghfour J, Ogunleye T
J Drugs Dermatol 2021 Apr 1;20(4):467-472. doi: 10.36849/JDD.2021.5555. PMID: 33852246
Treatment of dermatosis papulosa nigra using a carbon dioxide laser.
Furukawa F, Mizawa M, Shimizu T
J Cosmet Dermatol 2020 Oct;19(10):2572-2575. Epub 2020 Jan 28 doi: 10.1111/jocd.13309. PMID: 31990432
What's new in objective assessment and treatment of facial hyperpigmentation?
Molinar VE, Taylor SC, Pandya AG
Dermatol Clin 2014 Apr;32(2):123-35. doi: 10.1016/j.det.2013.12.008. PMID: 24679999
Dermatosis Papulosa Nigra and 10,600-nm CO2 laser, a good choice.
Bruscino N, Conti R, Campolmi P, Bonan P, Cannarozzo G, Lazzeri L, Moretti S
J Cosmet Laser Ther 2014 Jun;16(3):114-6. Epub 2013 Nov 18 doi: 10.3109/14764172.2013.854640. PMID: 24131098

Prognosis

A Systematic Review on the Treatment of Dermatosis Papulosa Nigra.
Maghfour J, Ogunleye T
J Drugs Dermatol 2021 Apr 1;20(4):467-472. doi: 10.36849/JDD.2021.5555. PMID: 33852246
The color of skin: black diseases of the skin, nails, and mucosa.
Qiu CC, Brown AE, Lobitz GR, Shanker A, Hsu S
Clin Dermatol 2019 Sep-Oct;37(5):447-467. Epub 2019 Aug 17 doi: 10.1016/j.clindermatol.2019.08.003. PMID: 31896402
Clinical features and treatment of dermatosis papulosa nigra in migrants to Italy.
Calcaterra R, Franco G, Valenzano M, Fazio R, Morrone A
Skinmed 2010 Jul-Aug;8(4):207-9. PMID: 21137605
Study of the skin disease spectrum occurring in an Afro-Caribbean population.
Dunwell P, Rose A
Int J Dermatol 2003 Apr;42(4):287-9. doi: 10.1046/j.1365-4362.2003.01358.x. PMID: 12694494

Clinical prediction guides

Carbon dioxide laser ablation of dermatosis papulosa nigra: high satisfaction and few complications in patients with pigmented skin.
Ali FR, Bakkour W, Ferguson JE, Madan V
Lasers Med Sci 2016 Apr;31(3):593-5. Epub 2016 Feb 11 doi: 10.1007/s10103-016-1906-y. PMID: 26868030
Dermatosis Papulosa Nigra and 10,600-nm CO2 laser, a good choice.
Bruscino N, Conti R, Campolmi P, Bonan P, Cannarozzo G, Lazzeri L, Moretti S
J Cosmet Laser Ther 2014 Jun;16(3):114-6. Epub 2013 Nov 18 doi: 10.3109/14764172.2013.854640. PMID: 24131098
Clinical features and treatment of dermatosis papulosa nigra in migrants to Italy.
Calcaterra R, Franco G, Valenzano M, Fazio R, Morrone A
Skinmed 2010 Jul-Aug;8(4):207-9. PMID: 21137605
A randomized, double-blind comparison of two topical anesthetic formulations prior to electrodesiccation of dermatosis papulosa nigra.
Carter EL, Coppola CA, Barsanti FA
Dermatol Surg 2006 Jan;32(1):1-6. doi: 10.1111/1524-4725.2006.32000. PMID: 16393591

Recent systematic reviews

A Systematic Review on the Treatment of Dermatosis Papulosa Nigra.
Maghfour J, Ogunleye T
J Drugs Dermatol 2021 Apr 1;20(4):467-472. doi: 10.36849/JDD.2021.5555. PMID: 33852246

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