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Recurrent Malignant Nasopharyngeal Neoplasm

MedGen UID:
237176
•Concept ID:
C1377767
•
Neoplastic Process

Definition

The reemergence of a nasopharyngeal malignant neoplasm after a period of remission. [from NCI]

Professional guidelines

PubMed

Recurrent/Metastatic Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Heading?
Juarez-Vignon Whaley JJ, Afkhami M, Onyshchenko M, Massarelli E, Sampath S, Amini A, Bell D, Villaflor VM
Curr Treat Options Oncol 2023 Sep;24(9):1138-1166. Epub 2023 Jun 15 doi: 10.1007/s11864-023-01101-3. PMID: 37318724Free PMC Article
International Recommendations on Reirradiation by Intensity Modulated Radiation Therapy for Locally Recurrent Nasopharyngeal Carcinoma.
Ng WT, Soong YL, Ahn YC, AlHussain H, Choi HCW, Corry J, Grégoire V, Harrington KJ, Hu CS, Jensen K, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Pan JJ, Peters LJ, Poh SS, Rosenthal DI, Sanguineti G, Tao Y, Wee JT, Yom SS, Chua MLK, Lee AWM
Int J Radiat Oncol Biol Phys 2021 Jul 1;110(3):682-695. Epub 2021 Feb 9 doi: 10.1016/j.ijrobp.2021.01.041. PMID: 33571626
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314

Recent clinical studies

Etiology

Efficacy, safety, and biomarker analysis of Camrelizumab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma (CAPTAIN study).
Yang Y, Zhou T, Chen X, Li J, Pan J, He X, Lin L, Shi YR, Feng W, Xiong J, Yang K, Yu Q, Zhang Q, Hu D, Sun Y, Hu G, Li P, Shen L, Lin Q, Zhang B, Qu X, Zou J, Zhang L, Fang W, Zhao Y
J Immunother Cancer 2021 Dec;9(12) doi: 10.1136/jitc-2021-003790. PMID: 34933967Free PMC Article
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Nasopharyngeal carcinoma.
Chan AT
Ann Oncol 2010 Oct;21 Suppl 7:vii308-12. doi: 10.1093/annonc/mdq277. PMID: 20943634
Nasopharyngeal carcinoma.
Wei WI, Sham JS
Lancet 2005 Jun 11-17;365(9476):2041-54. doi: 10.1016/S0140-6736(05)66698-6. PMID: 15950718
Nasopharyngeal carcinomas: an update.
Spano JP, Busson P, Atlan D, Bourhis J, Pignon JP, Esteban C, Armand JP
Eur J Cancer 2003 Oct;39(15):2121-35. doi: 10.1016/s0959-8049(03)00367-8. PMID: 14522369

Diagnosis

Recurrent/Metastatic Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Heading?
Juarez-Vignon Whaley JJ, Afkhami M, Onyshchenko M, Massarelli E, Sampath S, Amini A, Bell D, Villaflor VM
Curr Treat Options Oncol 2023 Sep;24(9):1138-1166. Epub 2023 Jun 15 doi: 10.1007/s11864-023-01101-3. PMID: 37318724Free PMC Article
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Nasopharyngeal carcinoma.
Chan AT
Ann Oncol 2010 Oct;21 Suppl 7:vii308-12. doi: 10.1093/annonc/mdq277. PMID: 20943634
Nasopharyngeal carcinoma.
Chong VF, Ong CK
Eur J Radiol 2008 Jun;66(3):437-47. Epub 2008 May 15 doi: 10.1016/j.ejrad.2008.03.029. PMID: 18485650
Nasopharyngeal carcinoma.
Wei WI, Sham JS
Lancet 2005 Jun 11-17;365(9476):2041-54. doi: 10.1016/S0140-6736(05)66698-6. PMID: 15950718

Therapy

Toripalimab Plus Chemotherapy for Recurrent or Metastatic Nasopharyngeal Carcinoma: The JUPITER-02 Randomized Clinical Trial.
Mai HQ, Chen QY, Chen D, Hu C, Yang K, Wen J, Li J, Shi Y, Jin F, Xu R, Pan J, Qu S, Li P, Hu C, Liu YC, Jiang Y, He X, Wang HM, Lim WT, Liao W, He X, Chen X, Wang S, Yuan X, Li Q, Lin X, Jing S, Chen Y, Lu Y, Hsieh CY, Yang MH, Yen CJ, Samol J, Luo X, Wang X, Tang X, Feng H, Yao S, Keegan P, Xu RH
JAMA 2023 Nov 28;330(20):1961-1970. doi: 10.1001/jama.2023.20181. PMID: 38015220Free PMC Article
Tislelizumab plus chemotherapy as first-line treatment for recurrent or metastatic nasopharyngeal cancer: A multicenter phase 3 trial (RATIONALE-309).
Yang Y, Pan J, Wang H, Zhao Y, Qu S, Chen N, Chen X, Sun Y, He X, Hu C, Lin L, Yu Q, Wang S, Wang G, Lei F, Wen J, Yang K, Lin Z, Guo Y, Chen S, Huang X, Wu Y, Liang L, Chen C, Bai F, Ma X, Zhang Y, Leaw S, Zhang L, Fang W
Cancer Cell 2023 Jun 12;41(6):1061-1072.e4. Epub 2023 May 18 doi: 10.1016/j.ccell.2023.04.014. PMID: 37207654
Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
You R, Liu YP, Xie YL, Lin C, Duan CY, Chen DP, Pan Y, Qi B, Zou X, Guo L, Cao JY, Zhang YN, Wang ZQ, Liu YL, Ouyang YF, Wen K, Yang Q, Xie RQ, Li HF, Duan XT, Ding X, Peng L, Chen SY, Liang JL, Feng ZK, Xia TL, Xie RL, Jiang R, Gu CM, Liu RZ, Sun R, Yang X, Liu LZ, Ling L, Liu Q, Ng WT, Hua YJ, Huang PY, Chen MY
Lancet 2023 Mar 18;401(10380):917-927. Epub 2023 Feb 23 doi: 10.1016/S0140-6736(23)00269-6. PMID: 36842439
Camrelizumab Plus Apatinib in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma: An Open-Label, Single-Arm, Phase II Study.
Ding X, Zhang WJ, You R, Zou X, Wang ZQ, Ouyang YF, Peng L, Liu YP, Duan CY, Yang Q, Lin C, Xie YL, Chen SY, Liu YL, Gu CM, Xie RQ, Huang PY, Hong MH, Hua YJ, Chen MY
J Clin Oncol 2023 May 10;41(14):2571-2582. Epub 2023 Feb 3 doi: 10.1200/JCO.22.01450. PMID: 36735896Free PMC Article
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article

Prognosis

Prospective randomized clinical studies involving reirradiation: update of a systematic review.
Nieder C, Willmann J, Andratschke NH
Strahlenther Onkol 2023 Sep;199(9):787-797. Epub 2023 Jul 27 doi: 10.1007/s00066-023-02118-1. PMID: 37500926Free PMC Article
Patterns and prognosis of regional recurrence in nasopharyngeal carcinoma after intensity-modulated radiotherapy.
Xiao XT, Wu YS, Chen YP, Liu X, Guo R, Tang LL, Ma J, Li WF
Cancer Med 2023 Jan;12(2):1399-1408. Epub 2022 Jul 13 doi: 10.1002/cam4.5020. PMID: 35822664Free PMC Article
Efficacy, safety, and biomarker analysis of Camrelizumab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma (CAPTAIN study).
Yang Y, Zhou T, Chen X, Li J, Pan J, He X, Lin L, Shi YR, Feng W, Xiong J, Yang K, Yu Q, Zhang Q, Hu D, Sun Y, Hu G, Li P, Shen L, Lin Q, Zhang B, Qu X, Zou J, Zhang L, Fang W, Zhao Y
J Immunother Cancer 2021 Dec;9(12) doi: 10.1136/jitc-2021-003790. PMID: 34933967Free PMC Article
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Juvenile nasopharyngeal angiofibroma staging: An overview.
Alshaikh NA, Eleftheriadou A
Ear Nose Throat J 2015 Jun;94(6):E12-22. doi: 10.1177/014556131509400615. PMID: 26053985

Clinical prediction guides

GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.
Chen Y, Feng Y, Lin Y, Zhou X, Wang L, Zhou Y, Lin K, Cai L
Br J Cancer 2024 Mar;130(5):755-768. Epub 2024 Jan 16 doi: 10.1038/s41416-024-02574-1. PMID: 38228715Free PMC Article
Prospective randomized clinical studies involving reirradiation: update of a systematic review.
Nieder C, Willmann J, Andratschke NH
Strahlenther Onkol 2023 Sep;199(9):787-797. Epub 2023 Jul 27 doi: 10.1007/s00066-023-02118-1. PMID: 37500926Free PMC Article
Tislelizumab plus chemotherapy as first-line treatment for recurrent or metastatic nasopharyngeal cancer: A multicenter phase 3 trial (RATIONALE-309).
Yang Y, Pan J, Wang H, Zhao Y, Qu S, Chen N, Chen X, Sun Y, He X, Hu C, Lin L, Yu Q, Wang S, Wang G, Lei F, Wen J, Yang K, Lin Z, Guo Y, Chen S, Huang X, Wu Y, Liang L, Chen C, Bai F, Ma X, Zhang Y, Leaw S, Zhang L, Fang W
Cancer Cell 2023 Jun 12;41(6):1061-1072.e4. Epub 2023 May 18 doi: 10.1016/j.ccell.2023.04.014. PMID: 37207654
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Juvenile nasopharyngeal angiofibroma staging: An overview.
Alshaikh NA, Eleftheriadou A
Ear Nose Throat J 2015 Jun;94(6):E12-22. doi: 10.1177/014556131509400615. PMID: 26053985

Recent systematic reviews

Prospective randomized clinical studies involving reirradiation: update of a systematic review.
Nieder C, Willmann J, Andratschke NH
Strahlenther Onkol 2023 Sep;199(9):787-797. Epub 2023 Jul 27 doi: 10.1007/s00066-023-02118-1. PMID: 37500926Free PMC Article
Embolization in Juvenile Nasopharyngeal Angiofibroma Surgery: A Systematic Review and Meta-Analysis.
Diaz A, Wang E, Bujnowski D, Arimoto R, Armstrong M, Cyberski T, Nordgren R, Seal SM, Kass-Hout T, Roxbury C
Laryngoscope 2023 Jul;133(7):1529-1539. Epub 2023 Feb 15 doi: 10.1002/lary.30616. PMID: 36789781
Salvage treatments for locally recurrent nasopharyngeal cancer: Systematic review and meta-analysis.
Wang D, Liao M, Wu J, Luo W, Qi S, Liu B, Li J
Head Neck 2023 Feb;45(2):503-520. Epub 2022 Nov 24 doi: 10.1002/hed.27253. PMID: 36420965
International Guideline on Dose Prioritization and Acceptance Criteria in Radiation Therapy Planning for Nasopharyngeal Carcinoma.
Lee AW, Ng WT, Pan JJ, Chiang CL, Poh SS, Choi HC, Ahn YC, AlHussain H, Corry J, Grau C, Grégoire V, Harrington KJ, Hu CS, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Peters LJ, Rosenthal DI, Sanguineti G, Soong YL, Tao Y, Yom SS, Wee JT
Int J Radiat Oncol Biol Phys 2019 Nov 1;105(3):567-580. Epub 2019 Jul 2 doi: 10.1016/j.ijrobp.2019.06.2540. PMID: 31276776
Systemic therapies for recurrent or metastatic nasopharyngeal carcinoma: a systematic review.
Prawira A, Oosting SF, Chen TW, Delos Santos KA, Saluja R, Wang L, Siu LL, Chan KKW, Hansen AR
Br J Cancer 2017 Dec 5;117(12):1743-1752. Epub 2017 Oct 24 doi: 10.1038/bjc.2017.357. PMID: 29065104Free PMC Article

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