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Benign neoplasm of oropharynx

MedGen UID:
87572
•Concept ID:
C0347229
•
Neoplastic Process
Synonyms: Benign Neoplasm of Oropharynx; benign neoplasm of oropharynx; Benign Neoplasm of the Oropharynx; benign neoplasm of the oropharynx; Benign Oropharyngeal Neoplasm; benign oropharyngeal neoplasm; Benign Oropharyngeal Tumor; benign oropharyngeal tumor; benign oropharyngeal tumour; Benign tumor of mesopharynx; Benign tumor of oropharynx; Benign Tumor of Oropharynx; benign tumor of oropharynx; Benign Tumor of the Oropharynx; benign tumor of the oropharynx; benign tumour of oropharynx; benign tumour of the oropharynx; Oropharyngeal Neoplasm Benign; oropharyngeal neoplasm benign; oropharynx benign neoplasm
SNOMED CT: Benign tumor of oropharynx (92259008); Benign tumor of mesopharynx (92259008); Benign neoplasm of oropharynx (92259008)
 
Monarch Initiative: MONDO:0021479

Definition

A neoplasm that arises from the oropharynx and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of oropharynx

Professional guidelines

PubMed

Selection of lymph node target volumes for definitive head and neck radiation therapy: a 2019 Update.
Biau J, Lapeyre M, Troussier I, Budach W, Giralt J, Grau C, Kazmierska J, Langendijk JA, Ozsahin M, O'Sullivan B, Bourhis J, Grégoire V
Radiother Oncol 2019 May;134:1-9. Epub 2019 Jan 30 doi: 10.1016/j.radonc.2019.01.018. PMID: 31005201
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

Chordoma of the Oropharynx.
Ramas A, Kasumovic M, Uscupsic S, Mujic M, Tokic L
Med Arch 2024;78(1):68-70. doi: 10.5455/medarh.2024.78.68-70. PMID: 38481587Free PMC Article
Tonsillectomy and the incidence of various types of cancer.
Holló G
Immunol Res 2021 Dec;69(6):467-470. Epub 2021 Sep 15 doi: 10.1007/s12026-021-09230-3. PMID: 34523058Free PMC Article
Clinical practice guideline for the prevention of oral and oropharyngeal mucositis in pediatric cancer and hematopoietic stem cell transplant patients: 2021 update.
Patel P, Robinson PD, Baggott C, Gibson P, Ljungman G, Massey N, Ottaviani G, Phillips R, Revon-Rivière G, Treister N, White M, Cabral S, Dupuis L, Sung L
Eur J Cancer 2021 Sep;154:92-101. Epub 2021 Jul 9 doi: 10.1016/j.ejca.2021.05.013. PMID: 34252760
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Gamma-delta t-cell lymphomas.
Foppoli M, Ferreri AJ
Eur J Haematol 2015 Mar;94(3):206-18. Epub 2014 Oct 1 doi: 10.1111/ejh.12439. PMID: 25154298

Diagnosis

Chordoma of the Oropharynx.
Ramas A, Kasumovic M, Uscupsic S, Mujic M, Tokic L
Med Arch 2024;78(1):68-70. doi: 10.5455/medarh.2024.78.68-70. PMID: 38481587Free PMC Article
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Paediatric parapharyngeal ganglioneuroma.
Bach J, Azher Q, Salih A
BMJ Case Rep 2018 Aug 20;2018 doi: 10.1136/bcr-2018-225763. PMID: 30131403Free PMC Article
Gamma-delta t-cell lymphomas.
Foppoli M, Ferreri AJ
Eur J Haematol 2015 Mar;94(3):206-18. Epub 2014 Oct 1 doi: 10.1111/ejh.12439. PMID: 25154298
The broad spectrum of lymphatic health and disease.
Rockson SG
Lymphat Res Biol 2010 Jun;8(2):101. doi: 10.1089/lrb.2010.8203. PMID: 20583871

Therapy

Efficacy and safety of pembrolizumab with preoperative neoadjuvant chemotherapy in patients with resectable locally advanced head and neck squamous cell carcinomas.
Wang K, Gui L, Lu H, He X, Li D, Liu C, Liu S, Wang X
Front Immunol 2023;14:1189752. Epub 2023 Jul 31 doi: 10.3389/fimmu.2023.1189752. PMID: 37583698Free PMC Article
Clinical practice guideline for the prevention of oral and oropharyngeal mucositis in pediatric cancer and hematopoietic stem cell transplant patients: 2021 update.
Patel P, Robinson PD, Baggott C, Gibson P, Ljungman G, Massey N, Ottaviani G, Phillips R, Revon-Rivière G, Treister N, White M, Cabral S, Dupuis L, Sung L
Eur J Cancer 2021 Sep;154:92-101. Epub 2021 Jul 9 doi: 10.1016/j.ejca.2021.05.013. PMID: 34252760
Management of the Neck in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx: ASCO Clinical Practice Guideline.
Koyfman SA, Ismaila N, Crook D, D'Cruz A, Rodriguez CP, Sher DJ, Silbermins D, Sturgis EM, Tsue TT, Weiss J, Yom SS, Holsinger FC
J Clin Oncol 2019 Jul 10;37(20):1753-1774. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01921. PMID: 30811281Free PMC Article
Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501).
Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL
Head Neck 2005 Oct;27(10):843-50. doi: 10.1002/hed.20279. PMID: 16161069
Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma.
Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Calais G
J Clin Oncol 2004 Jan 1;22(1):69-76. Epub 2003 Dec 2 doi: 10.1200/JCO.2004.08.021. PMID: 14657228

Prognosis

Radiation-Associated Sarcoma of the Head and Neck: Incidence, Latency, and Survival.
Smith JB, Cass LM, Simpson MC, Osazuwa-Peters N, Ward GM, Massa ST
Laryngoscope 2022 May;132(5):1034-1041. Epub 2021 Nov 15 doi: 10.1002/lary.29942. PMID: 34779517
Tonsillectomy and the incidence of various types of cancer.
Holló G
Immunol Res 2021 Dec;69(6):467-470. Epub 2021 Sep 15 doi: 10.1007/s12026-021-09230-3. PMID: 34523058Free PMC Article
Hypomagnesemia and incidence of osteoradionecrosis in patients with head and neck cancers.
Liu W, Qdaisat A, Zhou S, Fuller CD, Ferrarotto R, Guo M, Lai SY, Cardoso R, Mohamed ASR, Lopez G, Narayanan S, van Dijk LV, Cohen L, Bruera E, Yeung SJ, Hanna EY
Head Neck 2021 Feb;43(2):613-621. Epub 2020 Oct 23 doi: 10.1002/hed.26510. PMID: 33094893Free PMC Article
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Lymphangioma of the palatine tonsil.
Mardekian S, Karp JK
Arch Pathol Lab Med 2013 Dec;137(12):1837-42. doi: 10.5858/arpa.2012-0678-RS. PMID: 24283866

Clinical prediction guides

Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Tonsillectomy and the incidence of various types of cancer.
Holló G
Immunol Res 2021 Dec;69(6):467-470. Epub 2021 Sep 15 doi: 10.1007/s12026-021-09230-3. PMID: 34523058Free PMC Article
Clinical parameters predicting tonsillar malignancy.
Fellner A, Gavriel H, Pitaro J, Muallem Kalmovich L
Eur Arch Otorhinolaryngol 2020 Jun;277(6):1779-1783. Epub 2020 Mar 4 doi: 10.1007/s00405-020-05873-4. PMID: 32130510
The evolving landscape of HPV-related neoplasia in the head and neck.
Devins KM, Tetzlaff MT, Baloch Z, LiVolsi VA
Hum Pathol 2019 Dec;94:29-39. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.001. PMID: 31654690
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Recent systematic reviews

Global prevalence of human papillomavirus-related oral and oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis.
Fonsêca TC, Jural LA, Marañón-Vásquez GA, Magno MB, Roza ALOC, Ferreira DMTP, Maia LC, Romañach MJ, Agostini M, Abrahão AC
Clin Oral Investig 2023 Dec 30;28(1):62. doi: 10.1007/s00784-023-05425-0. PMID: 38158517
Expert Consensus Statement: Management of Dysphagia in Head and Neck Cancer Patients.
Kuhn MA, Gillespie MB, Ishman SL, Ishii LE, Brody R, Cohen E, Dhar SI, Hutcheson K, Jefferson G, Johnson F, Rameau A, Sher D, Starmer H, Strohl M, Ulmer K, Vaitaitis V, Begum S, Batjargal M, Dhepyasuwan N
Otolaryngol Head Neck Surg 2023 Apr;168(4):571-592. doi: 10.1002/ohn.302. PMID: 36965195
Interventions for head and neck cancer survivors: Systematic review.
Margalit DN, Salz T, Venchiarutti R, Milley K, McNamara M, Chima S, Wong J, Druce P, Nekhlyudov L
Head Neck 2022 Nov;44(11):2579-2599. Epub 2022 Jul 18 doi: 10.1002/hed.27142. PMID: 35848095Free PMC Article
Systematic review of neuroendocrine carcinomas of the oropharynx.
Froehlich MH, Shih MC, Shehee L, Kompelli AR, Aylward A, Nguyen SA, Kaczmar JM, Nathan CA, Day T, Neskey DM
Head Neck 2022 Jul;44(7):1725-1736. Epub 2022 Apr 18 doi: 10.1002/hed.27055. PMID: 35437851
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article

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