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Nasopharyngeal Pituitary Neuroendocrine Tumor

MedGen UID:
1777923
•Concept ID:
C5420164
•
Neoplastic Process
Synonyms: Nasopharyngeal PitNET/Adenoma; Nasopharyngeal Pituitary Gland Adenoma; Nasopharyngeal Pituitary Neuroendocrine Tumor/Adenoma

Definition

An ectopic pituitary neuroendocrine tumor that arises from the nasopharynx. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasopharyngeal Pituitary Neuroendocrine Tumor

Professional guidelines

PubMed

Ectopic pituitary adenomas: clinical features, diagnostic challenges and management.
Zhu J, Wang Z, Zhang Y, Li X, Liu J, Deng K, Lu L, Pan H, Wang R, Yao Y, Zhu H
Pituitary 2020 Dec;23(6):648-664. doi: 10.1007/s11102-020-01071-x. PMID: 32757141
Radiation induced optic neuropathy: Does treatment modality influence the risk?
Mohamed Ali A, Mathis T, Bensadoun RJ, Thariat J
Bull Cancer 2019 Dec;106(12):1160-1176. Epub 2019 Nov 19 doi: 10.1016/j.bulcan.2019.09.008. PMID: 31757405
The Differential Diagnosis of Sinonasal/Nasopharyngeal Neuroendocrine/Neuroectodermally Derived Tumors.
Montone KT
Arch Pathol Lab Med 2015 Dec;139(12):1498-507. doi: 10.5858/arpa.2014-0383-RA. PMID: 26619022

Recent clinical studies

Etiology

Radiation induced optic neuropathy: Does treatment modality influence the risk?
Mohamed Ali A, Mathis T, Bensadoun RJ, Thariat J
Bull Cancer 2019 Dec;106(12):1160-1176. Epub 2019 Nov 19 doi: 10.1016/j.bulcan.2019.09.008. PMID: 31757405
Risk factors for postoperative cerebrospinal fluid leak and meningitis after expanded endoscopic endonasal surgery.
Ivan ME, Iorgulescu JB, El-Sayed I, McDermott MW, Parsa AT, Pletcher SD, Jahangiri A, Wagner J, Aghi MK
J Clin Neurosci 2015 Jan;22(1):48-54. Epub 2014 Nov 22 doi: 10.1016/j.jocn.2014.08.009. PMID: 25439754
Tumors of the anterior skull base.
Ivan ME, Han SJ, Aghi MK
Expert Rev Neurother 2014 Apr;14(4):425-38. Epub 2014 Feb 25 doi: 10.1586/14737175.2014.892830. PMID: 24564556
Radiotherapy-induced hypopituitarism: a review.
Sathyapalan T, Dixit S
Expert Rev Anticancer Ther 2012 May;12(5):669-83. doi: 10.1586/era.12.27. PMID: 22594901
Infrasellar craniopharyngioma.
Yu X, Liu R, Wang Y, Wang H, Zhao H, Wu Z
Clin Neurol Neurosurg 2012 Feb;114(2):112-9. Epub 2011 Oct 21 doi: 10.1016/j.clineuro.2011.09.010. PMID: 22018920

Diagnosis

The Differential Diagnosis of Sinonasal/Nasopharyngeal Neuroendocrine/Neuroectodermally Derived Tumors.
Montone KT
Arch Pathol Lab Med 2015 Dec;139(12):1498-507. doi: 10.5858/arpa.2014-0383-RA. PMID: 26619022
Benign and malignant diseases of the clivus.
Neelakantan A, Rana AK
Clin Radiol 2014 Dec;69(12):1295-303. Epub 2014 Aug 29 doi: 10.1016/j.crad.2014.07.010. PMID: 25168701
Radiotherapy-induced hypopituitarism: a review.
Sathyapalan T, Dixit S
Expert Rev Anticancer Ther 2012 May;12(5):669-83. doi: 10.1586/era.12.27. PMID: 22594901
Hypopituitarism after cranial irradiation.
Darzy KH, Shalet SM
J Endocrinol Invest 2005;28(5 Suppl):78-87. PMID: 16114281
Radiation-induced growth hormone deficiency.
Darzy KH, Shalet SM
Horm Res 2003;59 Suppl 1:1-11. doi: 10.1159/000067834. PMID: 12566714

Therapy

Radiation induced optic neuropathy: Does treatment modality influence the risk?
Mohamed Ali A, Mathis T, Bensadoun RJ, Thariat J
Bull Cancer 2019 Dec;106(12):1160-1176. Epub 2019 Nov 19 doi: 10.1016/j.bulcan.2019.09.008. PMID: 31757405
Risk factors for postoperative cerebrospinal fluid leak and meningitis after expanded endoscopic endonasal surgery.
Ivan ME, Iorgulescu JB, El-Sayed I, McDermott MW, Parsa AT, Pletcher SD, Jahangiri A, Wagner J, Aghi MK
J Clin Neurosci 2015 Jan;22(1):48-54. Epub 2014 Nov 22 doi: 10.1016/j.jocn.2014.08.009. PMID: 25439754
Radiotherapy-induced hypopituitarism: a review.
Sathyapalan T, Dixit S
Expert Rev Anticancer Ther 2012 May;12(5):669-83. doi: 10.1586/era.12.27. PMID: 22594901
Pituitary dysfunction in adult patients after cranial radiotherapy: systematic review and meta-analysis.
Appelman-Dijkstra NM, Kokshoorn NE, Dekkers OM, Neelis KJ, Biermasz NR, Romijn JA, Smit JW, Pereira AM
J Clin Endocrinol Metab 2011 Aug;96(8):2330-40. Epub 2011 May 25 doi: 10.1210/jc.2011-0306. PMID: 21613351Free PMC Article
Radiation-induced growth hormone deficiency.
Darzy KH, Shalet SM
Horm Res 2003;59 Suppl 1:1-11. doi: 10.1159/000067834. PMID: 12566714

Prognosis

Nasopharyngeal B-cell lymphoma with pan-hypopituitarism and oculomotor nerve palsy: a case report and review of the literature.
Zahedi M, Hizomi Arani R, Tohidi M, Haghighi S, Mehrpour M, Hadaegh F
BMC Endocr Disord 2020 Nov 3;20(1):163. doi: 10.1186/s12902-020-00644-y. PMID: 33143716Free PMC Article
Radiation induced optic neuropathy: Does treatment modality influence the risk?
Mohamed Ali A, Mathis T, Bensadoun RJ, Thariat J
Bull Cancer 2019 Dec;106(12):1160-1176. Epub 2019 Nov 19 doi: 10.1016/j.bulcan.2019.09.008. PMID: 31757405
Risk factors for postoperative cerebrospinal fluid leak and meningitis after expanded endoscopic endonasal surgery.
Ivan ME, Iorgulescu JB, El-Sayed I, McDermott MW, Parsa AT, Pletcher SD, Jahangiri A, Wagner J, Aghi MK
J Clin Neurosci 2015 Jan;22(1):48-54. Epub 2014 Nov 22 doi: 10.1016/j.jocn.2014.08.009. PMID: 25439754
Infrasellar craniopharyngioma.
Yu X, Liu R, Wang Y, Wang H, Zhao H, Wu Z
Clin Neurol Neurosurg 2012 Feb;114(2):112-9. Epub 2011 Oct 21 doi: 10.1016/j.clineuro.2011.09.010. PMID: 22018920
Recurrent craniopharyngioma with nasopharyngeal extension.
Taguchi Y, Tanaka K, Miyakita Y, Sekino H, Fujimoto M
Pediatr Neurosurg 2000 Mar;32(3):140-4. doi: 10.1159/000028919. PMID: 10867561

Clinical prediction guides

Risk factors for postoperative cerebrospinal fluid leak and meningitis after expanded endoscopic endonasal surgery.
Ivan ME, Iorgulescu JB, El-Sayed I, McDermott MW, Parsa AT, Pletcher SD, Jahangiri A, Wagner J, Aghi MK
J Clin Neurosci 2015 Jan;22(1):48-54. Epub 2014 Nov 22 doi: 10.1016/j.jocn.2014.08.009. PMID: 25439754
Pituitary dysfunction in adult patients after cranial irradiation for head and nasopharyngeal tumours.
Appelman-Dijkstra NM, Malgo F, Neelis KJ, Coremans I, Biermasz NR, Pereira AM
Radiother Oncol 2014 Oct;113(1):102-7. Epub 2014 Sep 15 doi: 10.1016/j.radonc.2014.08.018. PMID: 25236713
Imaging of the cavernous sinus lesions.
Korchi AM, Cuvinciuc V, Caetano J, Becker M, Lovblad KO, Vargas MI
Diagn Interv Imaging 2014 Sep;95(9):849-59. Epub 2013 Jun 12 doi: 10.1016/j.diii.2013.04.013. PMID: 23763988
Pituitary carcinoma in situ.
Pasquel FJ, Vincentelli C, Brat DJ, Oyesiku NM, Ioachimescu AG
Endocr Pract 2013 May-Jun;19(3):e69-73. doi: 10.4158/EP12351.CR. PMID: 23425649
Infrasellar craniopharyngioma.
Yu X, Liu R, Wang Y, Wang H, Zhao H, Wu Z
Clin Neurol Neurosurg 2012 Feb;114(2):112-9. Epub 2011 Oct 21 doi: 10.1016/j.clineuro.2011.09.010. PMID: 22018920

Recent systematic reviews

Infrasellar Nasopharyngeal Craniopharyngiomas: An Individual Participant Data Meta-Analysis and Review of the Literature.
Maddy KS, Luther E, Ramsay IA, Berry K, Daggubati L, Morell A, Merenzon M, Eichberg DG, Shah A, Komotar R, Ivan M
World Neurosurg 2024 Jun;186:174-183.e1. Epub 2024 Mar 12 doi: 10.1016/j.wneu.2024.03.029. PMID: 38484970
Risk factors for postoperative cerebrospinal fluid leakage after transsphenoidal surgery for pituitary adenoma: a meta-analysis and systematic review.
Zhou Z, Zuo F, Chen X, Zhao Q, Luo M, Jiang X, Duan Y
BMC Neurol 2021 Oct 27;21(1):417. doi: 10.1186/s12883-021-02440-0. PMID: 34706659Free PMC Article
Ectopic ACTH-secreting pituitary adenoma of the sphenoid sinus: case report of endoscopic endonasal resection and systematic review of the literature.
Seltzer J, Lucas J, Commins D, Lerner O, Lerner A, Carmichael JD, Zada G
Neurosurg Focus 2015 Feb;38(2):E10. doi: 10.3171/2014.10.FOCUS14685. PMID: 25639312
Pituitary dysfunction in adult patients after cranial radiotherapy: systematic review and meta-analysis.
Appelman-Dijkstra NM, Kokshoorn NE, Dekkers OM, Neelis KJ, Biermasz NR, Romijn JA, Smit JW, Pereira AM
J Clin Endocrinol Metab 2011 Aug;96(8):2330-40. Epub 2011 May 25 doi: 10.1210/jc.2011-0306. PMID: 21613351Free PMC Article
Paediatric nasopharyngeal rhabdomyosarcoma: A case series and literature review.
Healy JN, Borg MF
J Med Imaging Radiat Oncol 2010 Aug;54(4):388-94. doi: 10.1111/j.1754-9485.2010.02187.x. PMID: 20718921

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