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Headache Disorders, Primary

MedGen UID:
297452
•Concept ID:
C1565106
•
Disease or Syndrome
Synonyms: Disorder, Primary Headache; Disorders, Primary Headache; Headache Disorder, Primary; Primary Headache Disorder; Primary Headache Disorders

Definition

Conditions in which the primary symptom is HEADACHE and the headache cannot be attributed to any known causes. [from MeSH]

Professional guidelines

PubMed

Diagnosis and Management of Headache: A Review.
Robbins MS
JAMA 2021 May 11;325(18):1874-1885. doi: 10.1001/jama.2021.1640. PMID: 33974014
Occipital Neuralgia and Cervicogenic Headache: Diagnosis and Management.
Barmherzig R, Kingston W
Curr Neurol Neurosci Rep 2019 Mar 19;19(5):20. doi: 10.1007/s11910-019-0937-8. PMID: 30888540
Evaluation and Management of the Emergency Department Headache.
Filler L, Akhter M, Nimlos P
Semin Neurol 2019 Feb;39(1):20-26. Epub 2019 Feb 11 doi: 10.1055/s-0038-1677023. PMID: 30743289

Recent clinical studies

Etiology

Reversible cerebral vasoconstriction syndrome: review of neuroimaging findings.
Perillo T, Paolella C, Perrotta G, Serino A, Caranci F, Manto A
Radiol Med 2022 Sep;127(9):981-990. Epub 2022 Aug 6 doi: 10.1007/s11547-022-01532-2. PMID: 35932443Free PMC Article
Updates in the Diagnostic Approach of Headache.
Do TP, la Cour Karottki NF, Ashina M
Curr Pain Headache Rep 2021 Dec 11;25(12):80. doi: 10.1007/s11916-021-00995-8. PMID: 34894320
Other primary headaches-thunderclap-, cough-, exertional-, and sexual headache.
Bahra A
J Neurol 2020 May;267(5):1554-1566. Epub 2020 Mar 4 doi: 10.1007/s00415-020-09728-0. PMID: 32130497Free PMC Article
Primary headaches.
Onderwater GLJ, Van Dongen RM, Zielman R, Terwindt GM, Ferrari MD
Handb Clin Neurol 2017;146:267-284. doi: 10.1016/B978-0-12-804279-3.00016-2. PMID: 29110775
Guideline for primary care management of headache in adults.
Becker WJ, Findlay T, Moga C, Scott NA, Harstall C, Taenzer P
Can Fam Physician 2015 Aug;61(8):670-9. PMID: 26273080Free PMC Article

Diagnosis

Hypnic Headache - What do we know in 2022?
Lindner D, Scheffler A, Nsaka M, Holle-Lee D
Cephalalgia 2023 Mar;43(3):3331024221148659. doi: 10.1177/03331024221148659. PMID: 36786376
Classification and Diagnosis of Primary Headache Disorders.
Levin M
Semin Neurol 2022 Aug;42(4):406-417. Epub 2022 Oct 3 doi: 10.1055/a-1954-3937. PMID: 36191595
Diagnosing Secondary and Primary Headache Disorders.
Dodick DW
Continuum (Minneap Minn) 2021 Jun 1;27(3):572-585. doi: 10.1212/CON.0000000000000980. PMID: 34048392
Primary headaches.
Onderwater GLJ, Van Dongen RM, Zielman R, Terwindt GM, Ferrari MD
Handb Clin Neurol 2017;146:267-284. doi: 10.1016/B978-0-12-804279-3.00016-2. PMID: 29110775
Guideline for primary care management of headache in adults.
Becker WJ, Findlay T, Moga C, Scott NA, Harstall C, Taenzer P
Can Fam Physician 2015 Aug;61(8):670-9. PMID: 26273080Free PMC Article

Therapy

Other Primary Headache Disorders.
Smith JH
Continuum (Minneap Minn) 2021 Jun 1;27(3):652-664. doi: 10.1212/CON.0000000000000960. PMID: 34048397
Primary Exercise Headache.
Upadhyaya P, Nandyala A, Ailani J
Curr Neurol Neurosci Rep 2020 Apr 15;20(5):9. doi: 10.1007/s11910-020-01028-4. PMID: 32296942Free PMC Article
Ice Pick Headache.
Chua AL, Nahas S
Curr Pain Headache Rep 2016 May;20(5):30. doi: 10.1007/s11916-016-0559-7. PMID: 27038969
Rare primary headaches.
Holle D, Obermann M
Curr Opin Neurol 2014 Jun;27(3):332-6. doi: 10.1097/WCO.0000000000000089. PMID: 24792342
Primary headache disorders.
Benoliel R, Eliav E
Dent Clin North Am 2013 Jul;57(3):513-39. Epub 2013 Jun 4 doi: 10.1016/j.cden.2013.04.005. PMID: 23809307

Prognosis

Reversible cerebral vasoconstriction syndrome: review of neuroimaging findings.
Perillo T, Paolella C, Perrotta G, Serino A, Caranci F, Manto A
Radiol Med 2022 Sep;127(9):981-990. Epub 2022 Aug 6 doi: 10.1007/s11547-022-01532-2. PMID: 35932443Free PMC Article
Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome as Syndromes of Cerebrovascular Dysregulation.
Singhal AB
Continuum (Minneap Minn) 2021 Oct 1;27(5):1301-1320. doi: 10.1212/CON.0000000000001037. PMID: 34618761
Primary Stabbing Headache.
Murray D, Dilli E
Curr Neurol Neurosci Rep 2019 Jun 8;19(7):47. doi: 10.1007/s11910-019-0955-6. PMID: 31175457
Primary headaches.
Onderwater GLJ, Van Dongen RM, Zielman R, Terwindt GM, Ferrari MD
Handb Clin Neurol 2017;146:267-284. doi: 10.1016/B978-0-12-804279-3.00016-2. PMID: 29110775
Thunderclap headache.
Dilli E
Curr Neurol Neurosci Rep 2014 Apr;14(4):437. doi: 10.1007/s11910-014-0437-9. PMID: 24643327

Clinical prediction guides

Primary Cough Headache.
Nandyala A, Zhang N
Curr Pain Headache Rep 2023 Nov;27(11):679-684. Epub 2023 Sep 25 doi: 10.1007/s11916-023-01171-w. PMID: 37747622
Other Primary Headache Disorders.
Smith JH
Continuum (Minneap Minn) 2021 Jun 1;27(3):652-664. doi: 10.1212/CON.0000000000000960. PMID: 34048397
Evaluating thunderclap headache.
Chen CY, Fuh JL
Curr Opin Neurol 2021 Jun 1;34(3):356-362. doi: 10.1097/WCO.0000000000000917. PMID: 33661161
RCVS(2) score and diagnostic approach for reversible cerebral vasoconstriction syndrome.
Rocha EA, Topcuoglu MA, Silva GS, Singhal AB
Neurology 2019 Feb 12;92(7):e639-e647. Epub 2019 Jan 11 doi: 10.1212/WNL.0000000000006917. PMID: 30635475
Primary headaches.
Onderwater GLJ, Van Dongen RM, Zielman R, Terwindt GM, Ferrari MD
Handb Clin Neurol 2017;146:267-284. doi: 10.1016/B978-0-12-804279-3.00016-2. PMID: 29110775

Recent systematic reviews

Epidemiology and clinical features of hypnic headache: A systematic review and meta-analysis.
Melchior AG, Ayyoub A, Christensen RH, Al-Khazali HM, Amin FM, Ashina H
Cephalalgia 2023 Dec;43(12):3331024231218389. doi: 10.1177/03331024231218389. PMID: 38051816
Association between primary headaches and temporomandibular disorders: A systematic review and meta-analysis.
Réus JC, Polmann H, Souza BDM, Flores-Mir C, Gonçalves DAG, de Queiroz LP, Okeson J, De Luca Canto G
J Am Dent Assoc 2022 Feb;153(2):120-131.e6. Epub 2021 Oct 12 doi: 10.1016/j.adaj.2021.07.021. PMID: 34649707
Reversible cerebral vasoconstriction syndrome: a comprehensive systematic review.
Song TJ, Lee KH, Li H, Kim JY, Chang K, Kim SH, Han KH, Kim BY, Kronbichler A, Ducros A, Koyanagi A, Jacob L, Kim MS, Yon DK, Lee SW, Yang JM, Hong SH, Ghayda RA, Kang JW, Shin JI, Smith L
Eur Rev Med Pharmacol Sci 2021 May;25(9):3519-3529. doi: 10.26355/eurrev_202105_25834. PMID: 34002826
Spontaneous extracranial hemorrhagic phenomena in primary headache disorders: A systematic review of published cases.
Peretz AM, Woldeamanuel YW, Rapoport AM, Cowan RP
Cephalalgia 2016 Nov;36(13):1257-1267. Epub 2016 Jul 19 doi: 10.1177/0333102415618951. PMID: 26611681
WITHDRAWN: Dipyrone for acute primary headaches.
Ramacciotti AS, Soares BG, Atallah AN
Cochrane Database Syst Rev 2014 Jul 11;2014(7):CD004842. doi: 10.1002/14651858.CD004842.pub3. PMID: 25019294Free PMC Article

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