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Migraine, familial typical, susceptibility to, 2

MedGen UID:
341144
Concept ID:
C1848066
Finding
Synonym: Migraine with or without aura, susceptibility to, 2
 
Monarch Initiative: MONDO:0010253
OMIM®: 300125

Clinical features

From HPO
Nausea
MedGen UID:
10196
Concept ID:
C0027497
Sign or Symptom
A sensation of unease in the stomach together with an urge to vomit.
Vomiting
MedGen UID:
12124
Concept ID:
C0042963
Sign or Symptom
Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.
Photophobia
MedGen UID:
43220
Concept ID:
C0085636
Sign or Symptom
Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.
Migraine with aura
MedGen UID:
57822
Concept ID:
C0154723
Disease or Syndrome
A type of migraine in which there is an aura characterized by focal neurological phenomena that usually proceed, but may accompany or occur in the absence of, the headache. The symptoms of an aura may include fully reversible visual, sensory, and speech symptoms but not motor weakness. Visual symptoms may include flickering lights, spots and lines and/or loss of vision and/or unilateral sensory symptoms such as paresthesias or numbness. At least one of the symptoms of an aura develops gradually over 5 or more minutes and/or different symptoms occur in succession.
Migraine without aura
MedGen UID:
137899
Concept ID:
C0338480
Disease or Syndrome
Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria
Phonophobia
MedGen UID:
155864
Concept ID:
C0751466
Mental or Behavioral Dysfunction
An abnormally heightened sensitivity to loud sounds.

Recent clinical studies

Etiology

Gormley P, Kurki MI, Hiekkala ME, Veerapen K, Häppölä P, Mitchell AA, Lal D, Palta P, Surakka I, Kaunisto MA, Hämäläinen E, Vepsäläinen S, Havanka H, Harno H, Ilmavirta M, Nissilä M, Säkö E, Sumelahti ML, Liukkonen J, Sillanpää M, Metsähonkala L, Koskinen S, Lehtimäki T, Raitakari O, Männikkö M, Ran C, Belin AC, Jousilahti P, Anttila V, Salomaa V, Artto V, Färkkilä M; 23andMe Research Team; International Headache Genetics Consortium (IHGC), Runz H, Daly MJ, Neale BM, Ripatti S, Kallela M, Wessman M, Palotie A
Neuron 2018 May 16;98(4):743-753.e4. Epub 2018 May 3 doi: 10.1016/j.neuron.2018.04.014. PMID: 29731251Free PMC Article
Ambrosini A, D'Onofrio M, Buzzi MG, Arisi I, Grieco GS, Pierelli F, Santorelli FM, Schoenen J
Headache 2017 Jul;57(7):1136-1144. Epub 2017 Jun 1 doi: 10.1111/head.13107. PMID: 28573794
Nyholt DR, Gillespie NG, Merikangas KR, Treloar SA, Martin NG, Montgomery GW
Genet Epidemiol 2009 Feb;33(2):105-13. doi: 10.1002/gepi.20361. PMID: 18636479Free PMC Article
Nyholt DR, Morley KI, Ferreira MA, Medland SE, Boomsma DI, Heath AC, Merikangas KR, Montgomery GW, Martin NG
Am J Hum Genet 2005 Sep;77(3):500-12. Epub 2005 Jul 28 doi: 10.1086/444510. PMID: 16080125Free PMC Article

Therapy

Rozen TD
Headache 2018 May;58(5):688-699. Epub 2018 Mar 14 doi: 10.1111/head.13295. PMID: 29536529

Clinical prediction guides

Peddareddygari LR, Kramer PD, Hanna PA, Levenstien MA, Grewal RP
Can J Neurol Sci 2019 Sep;46(5):512-517. Epub 2019 Jul 1 doi: 10.1017/cjn.2019.64. PMID: 31258098
Gormley P, Kurki MI, Hiekkala ME, Veerapen K, Häppölä P, Mitchell AA, Lal D, Palta P, Surakka I, Kaunisto MA, Hämäläinen E, Vepsäläinen S, Havanka H, Harno H, Ilmavirta M, Nissilä M, Säkö E, Sumelahti ML, Liukkonen J, Sillanpää M, Metsähonkala L, Koskinen S, Lehtimäki T, Raitakari O, Männikkö M, Ran C, Belin AC, Jousilahti P, Anttila V, Salomaa V, Artto V, Färkkilä M; 23andMe Research Team; International Headache Genetics Consortium (IHGC), Runz H, Daly MJ, Neale BM, Ripatti S, Kallela M, Wessman M, Palotie A
Neuron 2018 May 16;98(4):743-753.e4. Epub 2018 May 3 doi: 10.1016/j.neuron.2018.04.014. PMID: 29731251Free PMC Article
Nyholt DR, Gillespie NG, Merikangas KR, Treloar SA, Martin NG, Montgomery GW
Genet Epidemiol 2009 Feb;33(2):105-13. doi: 10.1002/gepi.20361. PMID: 18636479Free PMC Article
Nyholt DR, Curtain RP, Griffiths LR
Hum Genet 2000 Jul;107(1):18-23. doi: 10.1007/s004390000329. PMID: 10982029

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