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Migraine with or without aura, susceptibility to, 12(MGR12)

MedGen UID:
388698
•Concept ID:
C2673676
•
Finding
Synonyms: MGR12; Migraine, with or without aura 12
 
Monarch Initiative: MONDO:0012715
OMIM®: 611706

Clinical features

From HPO
Nausea
MedGen UID:
10196
•Concept ID:
C0027497
•
Sign or Symptom
A sensation of unease in the stomach together with an urge to vomit.
See: Feature record | Search on this feature
Vomiting
MedGen UID:
12124
•Concept ID:
C0042963
•
Sign or Symptom
Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.
See: Feature record | Search on this feature
Headache
MedGen UID:
9149
•Concept ID:
C0018681
•
Sign or Symptom
Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.
See: Feature record | Search on this feature
Photophobia
MedGen UID:
43220
•Concept ID:
C0085636
•
Sign or Symptom
Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.
See: Feature record | Search on this feature
Migraine
MedGen UID:
57451
•Concept ID:
C0149931
•
Disease or Syndrome
Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms.
See: Feature record | Search on this feature
Phonophobia
MedGen UID:
155864
•Concept ID:
C0751466
•
Mental or Behavioral Dysfunction
An abnormally heightened sensitivity to loud sounds.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

The American Headache Society Consensus Statement: Update on integrating new migraine treatments into clinical practice.
Ailani J, Burch RC, Robbins MS; Board of Directors of the American Headache Society
Headache 2021 Jul;61(7):1021-1039. Epub 2021 Jun 23 doi: 10.1111/head.14153. PMID: 34160823
Migraine and Tension-Type Headache: Diagnosis and Treatment.
Burch R
Med Clin North Am 2019 Mar;103(2):215-233. Epub 2018 Dec 3 doi: 10.1016/j.mcna.2018.10.003. PMID: 30704678
The pathophysiology of migraine: implications for clinical management.
Charles A
Lancet Neurol 2018 Feb;17(2):174-182. Epub 2017 Dec 8 doi: 10.1016/S1474-4422(17)30435-0. PMID: 29229375

Recent clinical studies

Etiology

Pediatric migraine is characterized by traits of ecological and metabolic dysbiosis and inflammation.
Papetti L, Del Chierico F, Frattale I, Toto F, Scanu M, Mortera SL, Rapisarda F, Di Michele M, Monte G, Ursitti F, Sforza G, Putignani L, Valeriani M
J Headache Pain 2024 Oct 9;25(1):171. doi: 10.1186/s10194-024-01871-7. PMID: 39379796Free PMC Article
Somatic amplification and addiction profile as risk factors for medication overuse headache with chronic migraine.
Cesur E, Yavuz BG, Acar E, Özdemir Z, Soyukibar TE, Aydınlar EI
Neurol Sci 2024 Nov;45(11):5375-5383. Epub 2024 Jun 13 doi: 10.1007/s10072-024-07639-w. PMID: 38872072
FEATURES OF HEMODYNAMICS IN HEAD MAGISTRAL AND CEREBRAL ARTERIES IN THE PATIENTS WITH MIGRAINE.
Kalashnikov VI, Stoyanov AN, Pulyk AR, Bakumenko IK, Andreeva TА, Oliinyk S
Wiad Lek 2021;74(10 pt 1):2489-2493. PMID: 34897010
Acute migraine management in the emergency department: experience from a large Spanish tertiary hospital.
Navarro-Pérez MP, Ballesta-Martínez S, Rodríguez-Montolio J, Bellosta-Diago E, García-Noaín JA, Santos-Lasaosa S
Intern Emerg Med 2021 Nov;16(8):2243-2249. Epub 2021 Mar 12 doi: 10.1007/s11739-021-02698-9. PMID: 33712966
Prescribing practices of migraine-specific pharmacotherapy associated with emergency department use for migraine.
Cheng V, Billups SJ, Saseen JJ
Headache 2021 Mar;61(3):455-461. Epub 2020 Dec 30 doi: 10.1111/head.14029. PMID: 33377525

Diagnosis

Prevalence, characteristics, and treatment outcomes of migraine headache in Nigeria: a systematic review and meta-analysis.
Aderinto N, Olatunji G, Kokori E, Ogieuhi IJ, Babalola AE, Ukoaka B, Moradeyo A, Egbunu E, Afolabi S, Yusuf IA, Aboje JE
J Headache Pain 2024 Oct 8;25(1):172. doi: 10.1186/s10194-024-01869-1. PMID: 39379798Free PMC Article
Neurological abnormalities in individuals with Marfan syndrome: results from a genetically confirmed Italian cohort.
Benini M, Foschi M, Barone V, Vornetti G, Spinardi L, Mariucci E, Donti A, Cortelli P, Guarino M
Neurol Sci 2024 Nov;45(11):5355-5363. Epub 2024 Jun 5 doi: 10.1007/s10072-024-07625-2. PMID: 38837112
Treatment of Stapedial Myoclonus as a Migraine-Related Phenomenon.
Birkenbeuel JL, Tawk K, Martin EC, Abouzari M, Djalilian HR
Otol Neurotol 2023 Apr 1;44(4):388-391. Epub 2023 Feb 20 doi: 10.1097/MAO.0000000000003838. PMID: 36843031Free PMC Article
Acute migraine management in the emergency department: experience from a large Spanish tertiary hospital.
Navarro-Pérez MP, Ballesta-Martínez S, Rodríguez-Montolio J, Bellosta-Diago E, García-Noaín JA, Santos-Lasaosa S
Intern Emerg Med 2021 Nov;16(8):2243-2249. Epub 2021 Mar 12 doi: 10.1007/s11739-021-02698-9. PMID: 33712966
Prescribing practices of migraine-specific pharmacotherapy associated with emergency department use for migraine.
Cheng V, Billups SJ, Saseen JJ
Headache 2021 Mar;61(3):455-461. Epub 2020 Dec 30 doi: 10.1111/head.14029. PMID: 33377525

Therapy

Migraine in older adults.
Hugger SS, Do TP, Ashina H, Goicochea MT, Jenkins B, Sacco S, Lee MJ, Brennan KC, Amin FM, Steiner TJ, Ashina M
Lancet Neurol 2023 Oct;22(10):934-945. Epub 2023 Sep 14 doi: 10.1016/S1474-4422(23)00206-5. PMID: 37717587
Evaluating the efficacy of CGRP mAbs and gepants for the preventive treatment of migraine: A systematic review and network meta-analysis of phase 3 randomised controlled trials.
Haghdoost F, Puledda F, Garcia-Azorin D, Huessler EM, Messina R, Pozo-Rosich P
Cephalalgia 2023 Apr;43(4):3331024231159366. doi: 10.1177/03331024231159366. PMID: 36855951
Cognitive dysfunction and migraine.
Vuralli D, Ayata C, Bolay H
J Headache Pain 2018 Nov 15;19(1):109. doi: 10.1186/s10194-018-0933-4. PMID: 30442090Free PMC Article
Non-Pharmacological Approaches for Migraine.
Puledda F, Shields K
Neurotherapeutics 2018 Apr;15(2):336-345. doi: 10.1007/s13311-018-0623-6. PMID: 29616493Free PMC Article
Menstrual Migraine and Treatment Options: Review.
Maasumi K, Tepper SJ, Kriegler JS
Headache 2017 Feb;57(2):194-208. Epub 2016 Dec 2 doi: 10.1111/head.12978. PMID: 27910087

Prognosis

Global, regional, and national burden and trends of migraine among women of childbearing age from 1990 to 2021: insights from the Global Burden of Disease Study 2021.
Cen J, Wang Q, Cheng L, Gao Q, Wang H, Sun F
J Headache Pain 2024 Jun 7;25(1):96. doi: 10.1186/s10194-024-01798-z. PMID: 38844846Free PMC Article
Migrainous infarction.
Chiang CC, Chen SP
Handb Clin Neurol 2024;199:465-474. doi: 10.1016/B978-0-12-823357-3.00021-5. PMID: 38307663
Global, regional, and national burden of migraine in 204 countries and territories, 1990 to 2019.
Safiri S, Pourfathi H, Eagan A, Mansournia MA, Khodayari MT, Sullman MJM, Kaufman J, Collins G, Dai H, Bragazzi NL, Kolahi AA
Pain 2022 Feb 1;163(2):e293-e309. doi: 10.1097/j.pain.0000000000002275. PMID: 34001771
Hormonal influences in migraine - interactions of oestrogen, oxytocin and CGRP.
Krause DN, Warfvinge K, Haanes KA, Edvinsson L
Nat Rev Neurol 2021 Oct;17(10):621-633. Epub 2021 Sep 20 doi: 10.1038/s41582-021-00544-2. PMID: 34545218
The triggers or precipitants of the acute migraine attack.
Kelman L
Cephalalgia 2007 May;27(5):394-402. Epub 2007 Mar 30 doi: 10.1111/j.1468-2982.2007.01303.x. PMID: 17403039

Clinical prediction guides

Migraine and the Gender Divide.
Vanood A, Rangel IC, Starling AJ
Neurol Clin 2023 May;41(2):231-247. doi: 10.1016/j.ncl.2023.01.002. PMID: 37030955
Cognitive Behavioral Therapy for Migraine Headache: A Systematic Review and Meta-Analysis.
Bae JY, Sung HK, Kwon NY, Go HY, Kim TJ, Shin SM, Lee S
Medicina (Kaunas) 2021 Dec 28;58(1) doi: 10.3390/medicina58010044. PMID: 35056352Free PMC Article
Triggers, Protectors, and Predictors in Episodic Migraine.
Marmura MJ
Curr Pain Headache Rep 2018 Oct 5;22(12):81. doi: 10.1007/s11916-018-0734-0. PMID: 30291562
Acute stroke differential diagnosis: Stroke mimics.
Vilela P
Eur J Radiol 2017 Nov;96:133-144. Epub 2017 May 5 doi: 10.1016/j.ejrad.2017.05.008. PMID: 28551302
Vestibular migraine.
von Brevern M, Lempert T
Handb Clin Neurol 2016;137:301-16. doi: 10.1016/B978-0-444-63437-5.00022-4. PMID: 27638080

Recent systematic reviews

Botox (OnabotulinumtoxinA) for Treatment of Migraine Symptoms: A Systematic Review.
Shaterian N, Shaterian N, Ghanaatpisheh A, Abbasi F, Daniali S, Jahromi MJ, Sanie MS, Abdoli A
Pain Res Manag 2022;2022:3284446. Epub 2022 Mar 31 doi: 10.1155/2022/3284446. PMID: 35401888Free PMC Article
Acute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis.
VanderPluym JH, Halker Singh RB, Urtecho M, Morrow AS, Nayfeh T, Torres Roldan VD, Farah MH, Hasan B, Saadi S, Shah S, Abd-Rabu R, Daraz L, Prokop LJ, Murad MH, Wang Z
JAMA 2021 Jun 15;325(23):2357-2369. doi: 10.1001/jama.2021.7939. PMID: 34128998Free PMC Article
Migraine and sleep disorders: a systematic review.
Tiseo C, Vacca A, Felbush A, Filimonova T, Gai A, Glazyrina T, Hubalek IA, Marchenko Y, Overeem LH, Piroso S, Tkachev A, Martelletti P, Sacco S; European Headache Federation School of Advanced Studies (EHF-SAS)
J Headache Pain 2020 Oct 27;21(1):126. doi: 10.1186/s10194-020-01192-5. PMID: 33109076Free PMC Article
The Role of Diet and Nutrition in Migraine Triggers and Treatment: A Systematic Literature Review.
Hindiyeh NA, Zhang N, Farrar M, Banerjee P, Lombard L, Aurora SK
Headache 2020 Jul;60(7):1300-1316. Epub 2020 May 25 doi: 10.1111/head.13836. PMID: 32449944Free PMC Article
Manual therapies for migraine: a systematic review.
Chaibi A, Tuchin PJ, Russell MB
J Headache Pain 2011 Apr;12(2):127-33. Epub 2011 Feb 5 doi: 10.1007/s10194-011-0296-6. PMID: 21298314Free PMC Article

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