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Metastatic Vaginal Squamous Cell Carcinoma

MedGen UID:
1793235
•Concept ID:
C5556794
•
Neoplastic Process

Definition

Vaginal squamous cell carcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Vaginal Squamous Cell Carcinoma

Professional guidelines

PubMed

Anal cancer: French Intergroup Clinical Practice Guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, SNFCP).
Moureau-Zabotto L, Vendrely V, Abramowitz L, Borg C, Francois E, Goere D, Huguet F, Peiffert D, Siproudhis L, Ducreux M, Bouché O
Dig Liver Dis 2017 Aug;49(8):831-840. Epub 2017 May 23 doi: 10.1016/j.dld.2017.05.011. PMID: 28610905
Management of Isolated Vaginal Metastasis in Squamous Cell Cervical Cancer: 23 Years' Experience at a Single Center.
Güngördük K, Kocaer M, Gülseren V, Özdemir AI, Gokcu M, Güngördük O, Sancı M
Oncol Res Treat 2016;39(10):616-621. Epub 2016 Sep 10 doi: 10.1159/000448540. PMID: 27710973
Management of Early Stage Cervical Cancer.
Somashekhar SP, Ashwin KR
Rev Recent Clin Trials 2015;10(4):302-8. doi: 10.2174/1574887110666150923113629. PMID: 26411950

Recent clinical studies

Etiology

Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Concomitant Chemotherapy and Radiotherapy in Patients With Stage IB2, IIA, or IIB Squamous Cervical Cancer: A Randomized Controlled Trial.
Gupta S, Maheshwari A, Parab P, Mahantshetty U, Hawaldar R, Sastri Chopra S, Kerkar R, Engineer R, Tongaonkar H, Ghosh J, Gulia S, Kumar N, Shylasree TS, Gawade R, Kembhavi Y, Gaikar M, Menon S, Thakur M, Shrivastava S, Badwe R
J Clin Oncol 2018 Jun 1;36(16):1548-1555. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.9985. PMID: 29432076
Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis.
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463
Prevention of cervix cancer.
Rock CL, Michael CW, Reynolds RK, Ruffin MT
Crit Rev Oncol Hematol 2000 Mar;33(3):169-85. doi: 10.1016/s1040-8428(99)00073-6. PMID: 10789491

Diagnosis

Diagnosis of advanced cervical cancer, missed opportunities?
Mattern J, Letendre I, Sibiude J, Pénager C, Jnifen A, Souare F, Ayel S, Nguyen T, Mandelbrot L
BMC Womens Health 2022 Mar 30;22(1):97. doi: 10.1186/s12905-022-01668-3. PMID: 35354463Free PMC Article
Gynecologic tumor board: a radiologist's guide to vulvar and vaginal malignancies.
Chow L, Tsui BQ, Bahrami S, Masamed R, Memarzadeh S, Raman SS, Patel MK
Abdom Radiol (NY) 2021 Dec;46(12):5669-5686. Epub 2021 Aug 25 doi: 10.1007/s00261-021-03209-2. PMID: 34435227Free PMC Article
Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis.
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463
Recurrent vulvar cancer.
Salom EM, Penalver M
Curr Treat Options Oncol 2002 Apr;3(2):143-53. doi: 10.1007/s11864-002-0060-x. PMID: 12057077

Therapy

Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Concomitant Chemotherapy and Radiotherapy in Patients With Stage IB2, IIA, or IIB Squamous Cervical Cancer: A Randomized Controlled Trial.
Gupta S, Maheshwari A, Parab P, Mahantshetty U, Hawaldar R, Sastri Chopra S, Kerkar R, Engineer R, Tongaonkar H, Ghosh J, Gulia S, Kumar N, Shylasree TS, Gawade R, Kembhavi Y, Gaikar M, Menon S, Thakur M, Shrivastava S, Badwe R
J Clin Oncol 2018 Jun 1;36(16):1548-1555. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.9985. PMID: 29432076
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis.
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463
Recurrent vulvar cancer.
Salom EM, Penalver M
Curr Treat Options Oncol 2002 Apr;3(2):143-53. doi: 10.1007/s11864-002-0060-x. PMID: 12057077
Prevention of cervix cancer.
Rock CL, Michael CW, Reynolds RK, Ruffin MT
Crit Rev Oncol Hematol 2000 Mar;33(3):169-85. doi: 10.1016/s1040-8428(99)00073-6. PMID: 10789491

Prognosis

Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial.
How JA, Jazaeri AA, Soliman PT, Fleming ND, Gong J, Piha-Paul SA, Janku F, Stephen B, Naing A
Sci Rep 2021 Feb 11;11(1):3667. doi: 10.1038/s41598-021-83317-7. PMID: 33574401Free PMC Article
Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Concomitant Chemotherapy and Radiotherapy in Patients With Stage IB2, IIA, or IIB Squamous Cervical Cancer: A Randomized Controlled Trial.
Gupta S, Maheshwari A, Parab P, Mahantshetty U, Hawaldar R, Sastri Chopra S, Kerkar R, Engineer R, Tongaonkar H, Ghosh J, Gulia S, Kumar N, Shylasree TS, Gawade R, Kembhavi Y, Gaikar M, Menon S, Thakur M, Shrivastava S, Badwe R
J Clin Oncol 2018 Jun 1;36(16):1548-1555. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.9985. PMID: 29432076
Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis.
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463
Recurrent vulvar cancer.
Salom EM, Penalver M
Curr Treat Options Oncol 2002 Apr;3(2):143-53. doi: 10.1007/s11864-002-0060-x. PMID: 12057077

Clinical prediction guides

Definitive chemoradiation in vulvar squamous cell carcinoma: outcome and toxicity from an observational multicenter Italian study on vulvar cancer (OLDLADY 1.1).
Macchia G, Lancellotta V, Ferioli M, Casà C, Pezzulla D, Pappalardi B, Laliscia C, Ippolito E, Di Muzio J, Huscher A, Tortoreto F, Boccardi M, Lazzari R, Perrone AM, Raspagliesi F, Gadducci A, Garganese G, Fragomeni SM, Ferrandina G, Morganti AG, Gambacorta MA, Tagliaferri L
Radiol Med 2024 Jan;129(1):152-159. Epub 2023 Sep 12 doi: 10.1007/s11547-023-01712-8. PMID: 37700153Free PMC Article
Survival associated with extent of radical hysterectomy in early-stage cervical cancer: a subanalysis of the Surveillance in Cervical CANcer (SCCAN) collaborative study.
Bizzarri N, Querleu D, Dostálek L, van Lonkhuijzen LRCW, Giannarelli D, Lopez A, Salehi S, Ayhan A, Kim SH, Ortiz DI, Klat J, Landoni F, Pareja R, Manchanda R, Kosťun J, Ramirez PT, Meydanli MM, Odetto D, Laky R, Zapardiel I, Weinberger V, Dos Reis R, Pedone Anchora L, Amaro K, Akilli H, Abu-Rustum NR, Salcedo-Hernández RA, Javůrková V, Mom CH, Scambia G, Falconer H, Cibula D
Am J Obstet Gynecol 2023 Oct;229(4):428.e1-428.e12. Epub 2023 Jun 17 doi: 10.1016/j.ajog.2023.06.030. PMID: 37336255Free PMC Article
Diagnosis of advanced cervical cancer, missed opportunities?
Mattern J, Letendre I, Sibiude J, Pénager C, Jnifen A, Souare F, Ayel S, Nguyen T, Mandelbrot L
BMC Womens Health 2022 Mar 30;22(1):97. doi: 10.1186/s12905-022-01668-3. PMID: 35354463Free PMC Article
Stage IA1 HPV-associated cervical squamous cell carcinoma metastasizing to ovary by special pathway: a case report and literature review.
Zhang Y, Zhang X, Wang H, Shen D
J Ovarian Res 2022 Feb 3;15(1):21. doi: 10.1186/s13048-022-00949-7. PMID: 35115032Free PMC Article
Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial.
How JA, Jazaeri AA, Soliman PT, Fleming ND, Gong J, Piha-Paul SA, Janku F, Stephen B, Naing A
Sci Rep 2021 Feb 11;11(1):3667. doi: 10.1038/s41598-021-83317-7. PMID: 33574401Free PMC Article

Recent systematic reviews

Glassy cell carcinoma of the cervix: a systematic review and meta-analysis.
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463
Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - a systematic review and meta-analysis.
Thomas LK, Bermejo JL, Vinokurova S, Jensen K, Bierkens M, Steenbergen R, Bergmann M, von Knebel Doeberitz M, Reuschenbach M
Eur J Cancer 2014 Jan;50(1):85-98. Epub 2013 Sep 17 doi: 10.1016/j.ejca.2013.08.022. PMID: 24054023

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