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Vaginal Papillary Carcinoma

MedGen UID:
925568
•Concept ID:
C4288036
•
Neoplastic Process
Synonyms: Vaginal Squamotransitional Carcinoma; Vaginal Squamotransitional Cell Carcinoma

Definition

A rare squamous cell carcinoma that arises from the vagina resembling transitional cell carcinoma of the urinary tract. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Papillary Carcinoma

Professional guidelines

PubMed

Impact of Chemotherapy and Radiotherapy on Management of Early Stage Clear Cell and Papillary Serous Carcinoma of the Uterus.
Hong JC, Foote J, Broadwater G, Gaillard S, Havrilesky LJ, Chino JP
Int J Gynecol Cancer 2017 May;27(4):720-729. doi: 10.1097/IGC.0000000000000926. PMID: 28375927
Uterine papillary serous carcinoma: epidemiology, pathogenesis and management.
Fader AN, Boruta D, Olawaiye AB, Gehrig PA
Curr Opin Obstet Gynecol 2010 Feb;22(1):21-9. doi: 10.1097/GCO.0b013e328334d8a3. PMID: 19952744
Management of women with uterine papillary serous cancer: a Society of Gynecologic Oncology (SGO) review.
Boruta DM 2nd, Gehrig PA, Fader AN, Olawaiye AB
Gynecol Oncol 2009 Oct;115(1):142-153. Epub 2009 Jul 9 doi: 10.1016/j.ygyno.2009.06.011. PMID: 19592079

Recent clinical studies

Etiology

Tumor lesions of penis and scrotum according to WHO classification 2022.
Michalová K, Beniač P, Kacerovská D
Cesk Patol 2022 Fall;67(4):192-197. PMID: 36513504
Uterine papillary serous and clear cell carcinomas: Comparison of characteristics and clinical outcomes.
Yuce Sari S, Guler OC, Oymak E, Gultekin M, Yigit E, Kahvecioglu A, Yuce K, Celik H, Usubutun A, Bolat F, Onal C, Yildiz F
J Obstet Gynaecol Res 2022 Jul;48(7):1876-1887. Epub 2022 Apr 6 doi: 10.1111/jog.15247. PMID: 35385171
Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia.
Ip PP, Irving JA, McCluggage WG, Clement PB, Young RH
Am J Surg Pathol 2013 Feb;37(2):167-77. doi: 10.1097/PAS.0b013e318272d428. PMID: 23211295
Vaginal brachytherapy alone is sufficient adjuvant treatment of surgical stage I endometrial cancer.
Solhjem MC, Petersen IA, Haddock MG
Int J Radiat Oncol Biol Phys 2005 Aug 1;62(5):1379-84. doi: 10.1016/j.ijrobp.2005.01.026. PMID: 16029796
Prognostic factors in endometrial cancer.
Ludwig H
Int J Gynaecol Obstet 1995 Jul;49 Suppl:S1-7. doi: 10.1016/0020-7292(95)02403-y. PMID: 7589734

Diagnosis

Psycho-Oncology and the Relevance of a Biopsychosocial Screening Program.
Bergerot CD, Bergerot PG, Molina LN, Lee D, Philip EJ, Bultz BD
Oncology (Williston Park) 2022 Sep 7;36(9):552-556. doi: 10.46883/2022.25920972. PMID: 36107784
Papillary squamotransitional cell carcinoma of the uterine cervix: a case report and review of the literature.
Gitas G, Ertan K, Rody A, Baum S, Tsolakidis D, Alkatout I
J Med Case Rep 2019 Oct 27;13(1):319. doi: 10.1186/s13256-019-2217-2. PMID: 31655625Free PMC Article
Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia.
Ip PP, Irving JA, McCluggage WG, Clement PB, Young RH
Am J Surg Pathol 2013 Feb;37(2):167-77. doi: 10.1097/PAS.0b013e318272d428. PMID: 23211295
Uterine papillary serous carcinoma: epidemiology, pathogenesis and management.
Fader AN, Boruta D, Olawaiye AB, Gehrig PA
Curr Opin Obstet Gynecol 2010 Feb;22(1):21-9. doi: 10.1097/GCO.0b013e328334d8a3. PMID: 19952744
Oncocytic metaplasia and carcinoma of the endometrium: an immunohistochemical and ultrastructural study.
Silver SA, Cheung AN, Tavassoli FA
Int J Gynecol Pathol 1999 Jan;18(1):12-9. doi: 10.1097/00004347-199901000-00003. PMID: 9891237

Therapy

Severe thrombocytopenia after trastuzumab in a patient with HER2-positive serous endometrial cancer.
Kucera C, Chappell N, Wang S
BMJ Case Rep 2023 Jun 1;16(6) doi: 10.1136/bcr-2023-255181. PMID: 37263678Free PMC Article
Psycho-Oncology and the Relevance of a Biopsychosocial Screening Program.
Bergerot CD, Bergerot PG, Molina LN, Lee D, Philip EJ, Bultz BD
Oncology (Williston Park) 2022 Sep 7;36(9):552-556. doi: 10.46883/2022.25920972. PMID: 36107784
Uterine papillary serous carcinoma: epidemiology, pathogenesis and management.
Fader AN, Boruta D, Olawaiye AB, Gehrig PA
Curr Opin Obstet Gynecol 2010 Feb;22(1):21-9. doi: 10.1097/GCO.0b013e328334d8a3. PMID: 19952744
Vaginal brachytherapy alone is sufficient adjuvant treatment of surgical stage I endometrial cancer.
Solhjem MC, Petersen IA, Haddock MG
Int J Radiat Oncol Biol Phys 2005 Aug 1;62(5):1379-84. doi: 10.1016/j.ijrobp.2005.01.026. PMID: 16029796
Outcome and patterns of failure in pathologic stages I-IV clear-cell carcinoma of the endometrium: implications for adjuvant radiation therapy.
Murphy KT, Rotmensch J, Yamada SD, Mundt AJ
Int J Radiat Oncol Biol Phys 2003 Apr 1;55(5):1272-6. doi: 10.1016/s0360-3016(02)04404-8. PMID: 12654437

Prognosis

Uterine papillary serous and clear cell carcinomas: Comparison of characteristics and clinical outcomes.
Yuce Sari S, Guler OC, Oymak E, Gultekin M, Yigit E, Kahvecioglu A, Yuce K, Celik H, Usubutun A, Bolat F, Onal C, Yildiz F
J Obstet Gynaecol Res 2022 Jul;48(7):1876-1887. Epub 2022 Apr 6 doi: 10.1111/jog.15247. PMID: 35385171
Papillary squamotransitional cell carcinoma of the uterine cervix: a case report and review of the literature.
Gitas G, Ertan K, Rody A, Baum S, Tsolakidis D, Alkatout I
J Med Case Rep 2019 Oct 27;13(1):319. doi: 10.1186/s13256-019-2217-2. PMID: 31655625Free PMC Article
Utility of radiation therapy for early-stage uterine papillary serous carcinoma.
Cham S, Huang Y, Tergas AI, Hou JY, Burke WM, Deutsch I, Ananth CV, Neugut AI, Hershman DL, Wright JD
Gynecol Oncol 2017 May;145(2):269-276. Epub 2017 Mar 23 doi: 10.1016/j.ygyno.2017.03.003. PMID: 28343693
Vaginal brachytherapy alone is sufficient adjuvant treatment of surgical stage I endometrial cancer.
Solhjem MC, Petersen IA, Haddock MG
Int J Radiat Oncol Biol Phys 2005 Aug 1;62(5):1379-84. doi: 10.1016/j.ijrobp.2005.01.026. PMID: 16029796
Prognostic factors in endometrial cancer.
Ludwig H
Int J Gynaecol Obstet 1995 Jul;49 Suppl:S1-7. doi: 10.1016/0020-7292(95)02403-y. PMID: 7589734

Clinical prediction guides

Severe thrombocytopenia after trastuzumab in a patient with HER2-positive serous endometrial cancer.
Kucera C, Chappell N, Wang S
BMJ Case Rep 2023 Jun 1;16(6) doi: 10.1136/bcr-2023-255181. PMID: 37263678Free PMC Article
Invasive stratified mucin-producing carcinoma (ISMC) of uterine cervix: description of pathological findings and prognosis factors in a series of 15 Chinese patients.
Lin T, Wang W, Xu L, He Y
Arch Gynecol Obstet 2022 Nov;306(5):1703-1709. Epub 2022 Apr 8 doi: 10.1007/s00404-022-06544-x. PMID: 35394200
Early-stage Uterine Pure and Mixed Clear Cell Carcinoma: Outcomes and Recurrence With and Without Adjuvant Therapy.
Chang-Halpenny CN, Natarajan S, Hwang-Graziano JM
Am J Clin Oncol 2018 Apr;41(4):371-378. doi: 10.1097/COC.0000000000000277. PMID: 26950465
Yolk Sac Tumor in Extragonadal Pelvic Sites: Still a Diagnostic Challenge.
Ravishankar S, Malpica A, Ramalingam P, Euscher ED
Am J Surg Pathol 2017 Jan;41(1):1-11. doi: 10.1097/PAS.0000000000000722. PMID: 27631522
Uterine papillary serous carcinoma: epidemiology, pathogenesis and management.
Fader AN, Boruta D, Olawaiye AB, Gehrig PA
Curr Opin Obstet Gynecol 2010 Feb;22(1):21-9. doi: 10.1097/GCO.0b013e328334d8a3. PMID: 19952744

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