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Vaginal Warty Carcinoma

MedGen UID:
274383
•Concept ID:
C1519937
•
Neoplastic Process

Definition

A squamous cell carcinoma that arises from the vagina and is characterized by a papillary growth pattern, hyperkeratosis, and koilocytosis. [from NCI]

Recent clinical studies

Etiology

Tumor lesions of penis and scrotum according to WHO classification 2022.
Michalová K, Beniač P, Kacerovská D
Cesk Patol 2022 Fall;67(4):192-197. PMID: 36513504
Usual vulval intraepithelial neoplasia in HIV-positive women - a case series.
Toby M, Conway K, Sethi G, Lewis F
Int J STD AIDS 2016 Dec;27(14):1253-1256. Epub 2015 Oct 14 doi: 10.1177/0956462415611513. PMID: 26472432
Premalignant lesions of the lower female genital tract: cervix, vagina and vulva.
McCluggage WG
Pathology 2013 Apr;45(3):214-28. doi: 10.1097/PAT.0b013e32835f21b1. PMID: 23442737
Warty (condylomatous) carcinoma of the cervix. A review of 3 cases with emphasis on thin-layer cytology and molecular analysis for HPV.
Ng WK, Cheung LK, Li AS
Acta Cytol 2003 Mar-Apr;47(2):159-66. doi: 10.1159/000326497. PMID: 12685182
Basaloid and warty carcinomas of the vulva. Distinctive types of squamous cell carcinoma frequently associated with human papillomaviruses.
Kurman RJ, Toki T, Schiffman MH
Am J Surg Pathol 1993 Feb;17(2):133-45. doi: 10.1097/00000478-199302000-00005. PMID: 8380681

Diagnosis

Metastatic Urothelial Carcinoma to the Uterine Cervix: A Case Report of a Rare Entity and Review of the Diagnostic Differential.
Sams SB, Rosser JA
Int J Gynecol Pathol 2017 Sep;36(5):493-498. doi: 10.1097/PGP.0000000000000343. PMID: 27801758
Usual vulval intraepithelial neoplasia in HIV-positive women - a case series.
Toby M, Conway K, Sethi G, Lewis F
Int J STD AIDS 2016 Dec;27(14):1253-1256. Epub 2015 Oct 14 doi: 10.1177/0956462415611513. PMID: 26472432
Warty (condylomatous) carcinoma of the cervix. A review of 3 cases with emphasis on thin-layer cytology and molecular analysis for HPV.
Ng WK, Cheung LK, Li AS
Acta Cytol 2003 Mar-Apr;47(2):159-66. doi: 10.1159/000326497. PMID: 12685182
Multifocal vulvar intraepithelial neoplasia grade III and multicentric lower genital tract neoplasia is associated with transcriptionally active human papillomavirus.
van Beurden M, ten Kate FJ, Smits HL, Berkhout RJ, de Craen AJ, van der Vange N, Lammes FB, ter Schegget J
Cancer 1995 Jun 15;75(12):2879-84. doi: 10.1002/1097-0142(19950615)75:12<2879::aid-cncr2820751214>3.0.co;2-w. PMID: 7773937
Verrucous carcinoma of the vagina.
Ramzy I, Smout MS, Collins JA
Am J Clin Pathol 1976 May;65(5):644-53. doi: 10.1093/ajcp/65.5.644. PMID: 16535806

Therapy

Usual vulval intraepithelial neoplasia in HIV-positive women - a case series.
Toby M, Conway K, Sethi G, Lewis F
Int J STD AIDS 2016 Dec;27(14):1253-1256. Epub 2015 Oct 14 doi: 10.1177/0956462415611513. PMID: 26472432

Prognosis

Basaloid and warty carcinomas of the vulva. Distinctive types of squamous cell carcinoma frequently associated with human papillomaviruses.
Kurman RJ, Toki T, Schiffman MH
Am J Surg Pathol 1993 Feb;17(2):133-45. doi: 10.1097/00000478-199302000-00005. PMID: 8380681

Clinical prediction guides

Large contribution of human papillomavirus in vaginal neoplastic lesions: a worldwide study in 597 samples.
Alemany L, Saunier M, Tinoco L, Quirós B, Alvarado-Cabrero I, Alejo M, Joura EA, Maldonado P, Klaustermeier J, Salmerón J, Bergeron C, Petry KU, Guimerà N, Clavero O, Murillo R, Clavel C, Wain V, Geraets DT, Jach R, Cross P, Carrilho C, Molina C, Shin HR, Mandys V, Nowakowski AM, Vidal A, Lombardi L, Kitchener H, Sica AR, Magaña-León C, Pawlita M, Quint W, Bravo IG, Muñoz N, de Sanjosé S, Bosch FX; HPV VVAP study group
Eur J Cancer 2014 Nov;50(16):2846-54. Epub 2014 Aug 21 doi: 10.1016/j.ejca.2014.07.018. PMID: 25155250
Warty (condylomatous) carcinoma of the cervix. A review of 3 cases with emphasis on thin-layer cytology and molecular analysis for HPV.
Ng WK, Cheung LK, Li AS
Acta Cytol 2003 Mar-Apr;47(2):159-66. doi: 10.1159/000326497. PMID: 12685182
Multifocal vulvar intraepithelial neoplasia grade III and multicentric lower genital tract neoplasia is associated with transcriptionally active human papillomavirus.
van Beurden M, ten Kate FJ, Smits HL, Berkhout RJ, de Craen AJ, van der Vange N, Lammes FB, ter Schegget J
Cancer 1995 Jun 15;75(12):2879-84. doi: 10.1002/1097-0142(19950615)75:12<2879::aid-cncr2820751214>3.0.co;2-w. PMID: 7773937

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