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Vaginal Non-Keratinizing Squamous Cell Carcinoma

MedGen UID:
276953
•Concept ID:
C1519927
•
Neoplastic Process

Definition

A squamous cell carcinoma that arises from the vagina and is characterized by the presence of polygonal squamous cells. Intercellular bridges and cytoplasmic keratinization may be present, but keratin pearls are absent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Non-Keratinizing Squamous Cell Carcinoma

Recent clinical studies

Etiology

Pathology of vaginal cancers in Port Harcourt, Nigeria. A 14-year study.
Seleye-Fubara D, Uzoigwe SA, Akani CI
Niger J Clin Pract 2007 Dec;10(4):330-4. PMID: 18293645

Diagnosis

Primary histiocytic sarcoma of the uterine cervix: an extremely rare entity.
Binesh F, Karimi-Zarchi M, Vahidfar MR, Hadgiabadi ZK
Rom J Intern Med 2017 Mar 1;55(1):53-56. doi: 10.1515/rjim-2016-0051. PMID: 27828780
An unexpected reason for elevated human chorionic gonadotropin in a young woman. Cervical squamous carcinoma.
Mustafa A, Bozdag Z, Tepe NB, Ozcan HC
Saudi Med J 2016 Aug;37(8):905-7. doi: 10.15537/2016.8.14529. PMID: 27464870Free PMC Article
Primary squamous cell carcinoma of the vagina: human papillomavirus detection, p16(INK4A) overexpression and clinicopathological correlations.
Fuste V, del Pino M, Perez A, Garcia A, Torne A, Pahisa J, Ordi J
Histopathology 2010 Dec;57(6):907-16. doi: 10.1111/j.1365-2559.2010.03727.x. PMID: 21166704
Pathology of vaginal cancers in Port Harcourt, Nigeria. A 14-year study.
Seleye-Fubara D, Uzoigwe SA, Akani CI
Niger J Clin Pract 2007 Dec;10(4):330-4. PMID: 18293645
Significance of mucin stain in uterine cervical cancers.
Sikka M, Agarwal S
Indian J Med Res 1991 Oct;94:375-7. PMID: 1724443

Therapy

Primary histiocytic sarcoma of the uterine cervix: an extremely rare entity.
Binesh F, Karimi-Zarchi M, Vahidfar MR, Hadgiabadi ZK
Rom J Intern Med 2017 Mar 1;55(1):53-56. doi: 10.1515/rjim-2016-0051. PMID: 27828780

Prognosis

Primary histiocytic sarcoma of the uterine cervix: an extremely rare entity.
Binesh F, Karimi-Zarchi M, Vahidfar MR, Hadgiabadi ZK
Rom J Intern Med 2017 Mar 1;55(1):53-56. doi: 10.1515/rjim-2016-0051. PMID: 27828780
Pathology of vaginal cancers in Port Harcourt, Nigeria. A 14-year study.
Seleye-Fubara D, Uzoigwe SA, Akani CI
Niger J Clin Pract 2007 Dec;10(4):330-4. PMID: 18293645
Primary invasive and in situ vaginal carcinoma. Flow cytometric analysis of DNA aneuploidy and cell proliferation from archival paraffin-embedded tissue.
Punnonen R, Kallioniemi OP, Mattila J, Väyrynen M, Koivula T
Eur J Obstet Gynecol Reprod Biol 1989 Sep;32(3):247-51. doi: 10.1016/0028-2243(89)90043-9. PMID: 2792545

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