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Childhood neoplasm

MedGen UID:: 237153
•Concept ID:: C1368871
•: Neoplastic Process

Synonyms:	Childhood Neoplasm; childhood neoplasm; childhood neoplasm (disease); Childhood Tumor; childhood tumor; childhood tumour; neoplasm (disease) of childhood; paediatric neoplasm; paediatric neoplasm (disease); paediatric tumour; Pediatric Neoplasm; pediatric neoplasm; pediatric neoplasm (disease); Pediatric Tumor; pediatric tumor

Monarch Initiative:	MONDO:0021079

Definition

A benign or malignant neoplasm that occurs during childhood. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

Childhood neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Neoplasm by Special Category
        Childhood neoplasm
        Childhood Central Nervous System Neoplasm
        Childhood astrocytic tumor
        Childhood Astrocytoma
        Childhood Glioblastoma
        Recurrent Childhood Astrocytic Tumor
        Childhood Benign Central Nervous System Neoplasm
        Childhood Benign Brain Neoplasm
        Childhood central nervous system mature teratoma
        Childhood central nervous system germ cell tumor
        Central nervous system endodermal sinus tumor
        Childhood central nervous system embryonal carcinoma
        Childhood central nervous system germinoma
        Childhood central nervous system mixed germ cell tumor
        Childhood Central Nervous System Teratoma
        Childhood germ cell brain tumor
        Pediatric CNS choriocarcinoma
        Childhood Ependymal Tumor
        Childhood Anaplastic Ependymoma
        Childhood ependymoma
        Childhood Myxopapillary Ependymoma
        Childhood ganglioglioma
        Childhood Intracranial Neoplasm
        Childhood Brain Neoplasm
        Childhood Malignant Central Nervous System Neoplasm
        Childhood Anaplastic Astrocytoma
        Childhood Anaplastic Oligoastrocytoma
        Childhood Anaplastic Oligodendroglioma
        Childhood Central Nervous System Embryonal Tumor
        Childhood choroid plexus carcinoma
        Childhood Gliomatosis Cerebri
        Childhood Grade 3 Meningioma
        Pediatric extraocular retinoblastoma
        Pediatric intraocular retinoblastoma
        Pediatric leptomeningeal melanoma
        Childhood Mixed Glioma
        Childhood Brain Stem Mixed Glioma
        Childhood Oligoastrocytoma
        Childhood oligodendroglioma
        Childhood Brain Oligodendroglioma
        Recurrent Childhood Oligodendroglioma
        Childhood spinal cord tumor
        Recurrent Childhood Spinal Cord Neoplasm
        Refractory Childhood Spinal Cord Neoplasm
        Pediatric meningioma
        Childhood brain meningioma
        Childhood Grade 1 Meningioma
        Childhood Grade 2 Meningioma
        Recurrent Childhood Central Nervous System Neoplasm
        Recurrent Childhood Anaplastic Oligoastrocytoma
        Recurrent Childhood Anaplastic Oligodendroglioma
        Recurrent Childhood Brain Neoplasm
        Recurrent Childhood Central Nervous System Embryonal Neoplasm
        Recurrent Childhood Ependymoma
        Recurrent Childhood Oligoastrocytoma
        Childhood Gastrointestinal Stromal Tumor
        Childhood germ cell tumor
        Childhood Benign Germ Cell Tumor
        Childhood Mature Teratoma
        Childhood Extracranial Germ Cell Tumor
        Childhood gonadal germ cell tumor
        Childhood Germinomatous Germ Cell Tumor
        Childhood Seminoma
        Pediatric ovarian dysgerminoma
        Childhood Nongerminomatous Germ Cell Tumor
        Childhood Choriocarcinoma
        Childhood Embryonal Carcinoma
        Childhood endodermal sinus tumor
        Childhood Ovarian Nongerminomatous Germ Cell Tumor
        Childhood Teratoma
        Childhood Testicular Non-Seminomatous Germ Cell Tumor
        Malignant childhood germ cell neoplasm
        Childhood Extragonadal Malignant Germ Cell Tumor
        Childhood Malignant Ovarian Germ Cell Tumor
        Childhood Malignant Testicular Germ Cell Tumor
        Childhood Mixed Germ Cell Tumor
        Recurrent Childhood Malignant Germ Cell Tumor
        Refractory Childhood Malignant Germ Cell Tumor
        Childhood kidney neoplasm
        Childhood kidney angiomyolipoma
        Childhood malignant kidney neoplasm
        Childhood kidney cell carcinoma
        Childhood kidney Wilms tumor
        Clear cell sarcoma of kidney
        Congenital mesoblastic nephroma
        Rhabdoid tumor of the kidney
        Childhood multilocular cystic kidney neoplasm
        Childhood Cystic Nephroma
        Cystic partially differentiated nephroblastoma
        Recurrent Childhood Kidney Neoplasm
        Recurrent Rhabdoid Tumor of the Kidney
        Childhood Liver Neoplasm
        Childhood Malignant Liver Neoplasm
        Calcifying nested epithelial stromal tumor of the liver
        Extrarenal Rhabdoid Tumor of the Liver
        Hepatoblastoma
        Hepatocellular Malignant Neoplasm, Not Otherwise Specified
        Pediatric hepatocellular carcinoma
        Recurrent Childhood Malignant Liver Neoplasm
        Childhood malignant neoplasm
        Childhood Ganglioneuroblastoma
        Childhood Central Nervous System Ganglioneuroblastoma
        Childhood Ganglioneuroblastoma, Intermixed
        Childhood Ganglioneuroblastoma, Nodular
        Childhood leukemia
        Childhood acute lymphoblastic leukemia
        Childhood acute myeloid leukemia
        Childhood Burkitt Leukemia
        Childhood Chronic Myeloid Leukemia, BCR-ABL1 Positive
        Infant Leukemia
        Childhood malignant schwannoma
        Childhood Malignant Solid Neoplasm
        Recurrent Childhood Malignant Solid Neoplasm
        Refractory Childhood Malignant Solid Neoplasm
        Childhood myelodysplastic syndrome
        Refractory cytopenia of childhood
        Childhood Neuroblastoma
        Childhood Central Nervous System Neuroblastoma
        Childhood precursor T-lymphoblastic lymphoma/leukemia
        T-cell childhood acute lymphocytic leukemia
        T-cell childhood lymphoblastic lymphoma
        Childhood Soft Tissue Sarcoma
        Childhood Alveolar Soft Part Sarcoma
        Childhood Clear Cell Sarcoma of Soft Tissue
        Childhood Desmoplastic Small Round Cell Tumor
        Childhood epithelioid sarcoma
        Childhood extraosseous osteosarcoma
        Childhood Leiomyosarcoma
        Childhood Rhabdomyosarcoma
        Childhood Synovial Sarcoma
        Childhood Undifferentiated Pleomorphic Sarcoma
        Localized Childhood Soft Tissue Sarcoma
        Metastatic Childhood Soft Tissue Sarcoma
        Pediatric mesenchymal chondrosarcoma
        Pediatric myxoid chondrosarcoma
        Recurrent Childhood Soft Tissue Sarcoma
        EBV-positive T-cell lymphoproliferative disorder of childhood
        Hydroa vacciniforme-like lymphoma
        Systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood
        Extrarenal rhabdoid tumor
        Extrarenal Rhabdoid Tumor of the Ovary
        Extrarenal Rhabdoid Tumor of the Prostate
        Myeloid leukemia associated with down syndrome
        Pediatric angiosarcoma
        Pediatric fibrosarcoma
        Pediatric liposarcoma
        Pediatric lymphoma
        Childhood Hodgkin Lymphoma
        Childhood Lymphoma by AJCC v8 Stage
        Childhood Non-Hodgkin Lymphoma
        Pediatric osteosarcoma
        Childhood intracortical osteosarcoma
        Childhood parosteal osteosarcoma
        Childhood Periosteal Osteosarcoma
        Rare Childhood Malignant Neoplasm
        Childhood bladder carcinoma
        Childhood Breast Carcinoma
        Childhood Colorectal Carcinoma
        Childhood Esophageal Carcinoma
        Childhood Gastric Carcinoma
        Childhood Laryngeal Carcinoma
        Childhood Lung Non-Small Cell Carcinoma
        Childhood Lung Small Cell Carcinoma
        Childhood malignant melanoma
        Childhood Malignant Penile Neoplasm
        Childhood Malignant Small Intestinal Neoplasm
        Childhood Nasal Cavity Carcinoma
        Childhood Paranasal Sinus Carcinoma
        Childhood Parathyroid Gland Carcinoma
        Childhood Salivary Gland Carcinoma
        Childhood Thyroid Gland Carcinoma
        Recurrent Childhood Malignant Neoplasm
        Recurrent Childhood Acute Lymphoblastic Leukemia
        Recurrent Childhood Acute Myeloid Leukemia
        Recurrent Childhood Anaplastic Astrocytoma
        Recurrent Childhood Glioblastoma
        Recurrent Childhood Gliomatosis Cerebri
        Recurrent Childhood Hodgkin Lymphoma
        Recurrent Childhood Non-Hodgkin Lymphoma
        Recurrent Extrarenal Rhabdoid Tumor of the Ovary
        Refractory Childhood Malignant Neoplasm
        Refractory Childhood Acute Lymphoblastic Leukemia
        Refractory Childhood Hodgkin Lymphoma
        Refractory Extrarenal Rhabdoid Tumor of the Ovary
        Refractory Hepatoblastoma
        Refractory Rhabdoid Tumor of the Kidney
        Transient myeloproliferative syndrome
        Childhood mediastinal neurogenic neoplasm
        Childhood Solid Neoplasm
        Childhood testicular neoplasm
        Childhood testicular germ cell tumor
        Vulvar Prepubertal Fibroma

Professional guidelines

PubMed

Advances in the diagnosis and treatment of neuroblastoma.

Weinstein JL, Katzenstein HM, Cohn SL
Oncologist 2003;8(3):278-92. doi: 10.1634/theoncologist.8-3-278. PMID: 12773750

Advances in the diagnosis and treatment of neuroblastoma.

Katzenstein HM, Cohn SL
Curr Opin Oncol 1998 Jan;10(1):43-51. doi: 10.1097/00001622-199801000-00008. PMID: 9466484

Current issues in the diagnosis and management of Wilms' tumor.

Paulino AC
Oncology (Williston Park) 1996 Oct;10(10):1553-65; discussion 1565-71. PMID: 8905846

See all (3)

Recent clinical studies

Etiology

Lipoblastoma of the extremities.

Rajput S, Alsubaie SA, Singh K, Huang TC, Moran SL
J Plast Reconstr Aesthet Surg 2022 Oct;75(10):3761-3767. Epub 2022 Jun 25 doi: 10.1016/j.bjps.2022.06.077. PMID: 36041974

Association Between Neonatal Phototherapy Exposure and Childhood Neoplasm.

Bugaiski-Shaked A, Shany E, Mesner O, Sergienko R, Wainstock T
J Pediatr 2022 Jun;245:111-116. Epub 2022 Feb 1 doi: 10.1016/j.jpeds.2022.01.046. PMID: 35120988

Family and parent-child relationship correlates of pediatric cancer survivors' substance use.

Tillery R, Willard VW, Gordon ML, Adams K, Long A, Phipps S
J Cancer Surviv 2022 Apr;16(2):329-337. Epub 2021 Mar 17 doi: 10.1007/s11764-021-01026-6. PMID: 33733380 Free PMC Article

Comprehensive Overview of Gene Rearrangements in Childhood T-Cell Acute Lymphoblastic Leukaemia.

Mroczek A, Zawitkowska J, Kowalczyk J, Lejman M
Int J Mol Sci 2021 Jan 15;22(2) doi: 10.3390/ijms22020808. PMID: 33467425 Free PMC Article

Advances in the diagnosis and treatment of neuroblastoma.

Weinstein JL, Katzenstein HM, Cohn SL
Oncologist 2003;8(3):278-92. doi: 10.1634/theoncologist.8-3-278. PMID: 12773750

See all (25)

Diagnosis

Lipoblastoma of the extremities.

Rajput S, Alsubaie SA, Singh K, Huang TC, Moran SL
J Plast Reconstr Aesthet Surg 2022 Oct;75(10):3761-3767. Epub 2022 Jun 25 doi: 10.1016/j.bjps.2022.06.077. PMID: 36041974

Impact of interpregnancy interval on long-term childhood neoplasm of the offspring.

Toledano R, Wainstock T, Sheiner E, Kessous R
J Matern Fetal Neonatal Med 2022 Dec;35(25):8611-8617. Epub 2021 Oct 18 doi: 10.1080/14767058.2021.1989406. PMID: 34662535

Comprehensive Overview of Gene Rearrangements in Childhood T-Cell Acute Lymphoblastic Leukaemia.

Mroczek A, Zawitkowska J, Kowalczyk J, Lejman M
Int J Mol Sci 2021 Jan 15;22(2) doi: 10.3390/ijms22020808. PMID: 33467425 Free PMC Article

Seasonal trends of diagnosis of childhood malignant diseases and viral prevalence in South Korea.

Shim KS, Kim MH, Shim CN, Han M, Lim IS, Chae SA, Yun SW, Lee NM, Yi DY, Kim H
Cancer Epidemiol 2017 Dec;51:118-124. Epub 2017 Nov 8 doi: 10.1016/j.canep.2017.11.003. PMID: 29127946 Free PMC Article

Advances in the diagnosis and treatment of neuroblastoma.

Weinstein JL, Katzenstein HM, Cohn SL
Oncologist 2003;8(3):278-92. doi: 10.1634/theoncologist.8-3-278. PMID: 12773750

See all (31)

Therapy

Association Between Neonatal Phototherapy Exposure and Childhood Neoplasm.

Bugaiski-Shaked A, Shany E, Mesner O, Sergienko R, Wainstock T
J Pediatr 2022 Jun;245:111-116. Epub 2022 Feb 1 doi: 10.1016/j.jpeds.2022.01.046. PMID: 35120988

Possible association between in vitro fertilization technologies and offspring neoplasm.

Bal MH, Harlev A, Sergienko R, Levitas E, Har-Vardi I, Zeadna A, Mark-Reich A, Becker H, Ben-David N, Naggan L, Wainstock T
Fertil Steril 2021 Jul;116(1):105-113. Epub 2021 Feb 14 doi: 10.1016/j.fertnstert.2020.12.013. PMID: 33597091

SETIL: Italian multicentric epidemiological case-control study on risk factors for childhood leukaemia, non hodgkin lymphoma and neuroblastoma: study population and prevalence of risk factors in Italy.

Magnani C, Mattioli S, Miligi L, Ranucci A, Rondelli R, Salvan A, Bisanti L, Masera G, Rizzari C, Zambon P, Cannizzaro S, Gafà L, Luzzatto LL, Benvenuti A, Michelozzi P, Kirchmayer U, Cocco P, Biddau P, Galassi C, Celentano E, Guarino E, Assennato G, de Nichilo G, Merlo DF, Bocchini V, Pannelli F, Mosciatti P, Minelli L, Chiavarini M, Cuttini M, Casotto V, Torregrossa MV, Valenti RM, Forastiere F, Haupt R, Lagorio S, Risica S, Polichetti A
Ital J Pediatr 2014 Dec 24;40:103. doi: 10.1186/s13052-014-0103-5. PMID: 25539823 Free PMC Article

A population-based case-control study of radiofrequency exposure in relation to childhood neoplasm.

Li CY, Liu CC, Chang YH, Chou LP, Ko MC
Sci Total Environ 2012 Oct 1;435-436:472-8. Epub 2012 Aug 9 doi: 10.1016/j.scitotenv.2012.06.078. PMID: 22885353

Pediatric adrenal cortical carcinoma: brain metastases and relationship to NF-1, case reports and review of the literature.

Wagner AS, Fleitz JM, Kleinschmidt-Demasters BK
J Neurooncol 2005 Nov;75(2):127-33. doi: 10.1007/s11060-005-0376-z. PMID: 16132517

See all (8)

Prognosis

Family and parent-child relationship correlates of pediatric cancer survivors' substance use.

Tillery R, Willard VW, Gordon ML, Adams K, Long A, Phipps S
J Cancer Surviv 2022 Apr;16(2):329-337. Epub 2021 Mar 17 doi: 10.1007/s11764-021-01026-6. PMID: 33733380 Free PMC Article

Possible association between in vitro fertilization technologies and offspring neoplasm.

Comprehensive Overview of Gene Rearrangements in Childhood T-Cell Acute Lymphoblastic Leukaemia.

Mroczek A, Zawitkowska J, Kowalczyk J, Lejman M
Int J Mol Sci 2021 Jan 15;22(2) doi: 10.3390/ijms22020808. PMID: 33467425 Free PMC Article

Advances in the diagnosis and treatment of neuroblastoma.

Weinstein JL, Katzenstein HM, Cohn SL
Oncologist 2003;8(3):278-92. doi: 10.1634/theoncologist.8-3-278. PMID: 12773750

Lipoblastoma and liposarcoma in children: an analysis of 9 cases and a review of the literature.

Miller GG, Yanchar NL, Magee JF, Blair GK
Can J Surg 1998 Dec;41(6):455-8. PMID: 9854536 Free PMC Article

See all (28)

Clinical prediction guides

Family and parent-child relationship correlates of pediatric cancer survivors' substance use.

Tillery R, Willard VW, Gordon ML, Adams K, Long A, Phipps S
J Cancer Surviv 2022 Apr;16(2):329-337. Epub 2021 Mar 17 doi: 10.1007/s11764-021-01026-6. PMID: 33733380 Free PMC Article

Programmed Death Ligand 1 Expression and Related Markers in Pleuropulmonary Blastoma.

Alipour Z, Schultz KAP, Chen L, Harris AK, Gonzalez IA, Pfeifer J, Hill DA, He M, Dehner LP
Pediatr Dev Pathol 2021 Nov-Dec;24(6):523-530. Epub 2021 Jul 15 doi: 10.1177/10935266211027417. PMID: 34266329 Free PMC Article

Comprehensive Overview of Gene Rearrangements in Childhood T-Cell Acute Lymphoblastic Leukaemia.

Mroczek A, Zawitkowska J, Kowalczyk J, Lejman M
Int J Mol Sci 2021 Jan 15;22(2) doi: 10.3390/ijms22020808. PMID: 33467425 Free PMC Article

HOXB13 controls cell state through super-enhancers.

Aspuria PJ, Cheon DJ, Gozo MC, Beach JA, Recouvreux MS, Walts AE, Karlan BY, Orsulic S
Exp Cell Res 2020 Aug 1;393(1):112039. Epub 2020 May 4 doi: 10.1016/j.yexcr.2020.112039. PMID: 32376288

Advances in the diagnosis and treatment of neuroblastoma.

Weinstein JL, Katzenstein HM, Cohn SL
Oncologist 2003;8(3):278-92. doi: 10.1634/theoncologist.8-3-278. PMID: 12773750

See all (16)

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Childhood neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

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