GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE38449 Query DataSets for GSE38449
Status Public on Jul 31, 2012
Title Gene expression analysis in skeletal muscle and heart of 11 days-old TK2 knockout mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary TK2 deficiency causes severe mtDNA depeltion in several tissues, including skeletal muscle and heart. TK2 knockout mice grow slower and their skeletal muscles appeared significantly underdeveloped, whereas heart was close to normal size.
We used microarrays in order to compare the transcriptomes in skeletal muscle and heart tissue of 11 days-old TK2 knockout pups with the sames tissues of wild-type pups at the same age.
Overall design We collected skeletal muscle from the hind limb and hearts of three 11 days-old TK2 knockout and three wild-type pups and extracted total RNA. These RNA samples were used for hybridization in Affymetrix arrays.
Contributor(s) Paredes JA, Karlsson A
Citation(s) 23341978
Submission date Jun 04, 2012
Last update date Apr 18, 2017
Contact name João Amorim Paredes
Organization name Karolinska Institute
Department Laboratory Medicine
Lab Anna Karlsson
Street address Karolinska Universitetssjukhuset Huddinge, F68
City Huddinge
State/province Stockholm
ZIP/Postal code 14186
Country Sweden
Platforms (1)
GPL11533 [MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version]
Samples (12)
GSM942212 wt skel muscle, biological rep1
GSM942213 wt skel muscle, biological rep2
GSM942214 wt skel muscle, biological rep3
BioProject PRJNA167961

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE38449_RAW.tar 51.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap