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| Status |
Public on Jul 31, 2012 |
| Title |
Gene expression analysis in skeletal muscle and heart of 11 days-old TK2 knockout mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
TK2 deficiency causes severe mtDNA depeltion in several tissues, including skeletal muscle and heart. TK2 knockout mice grow slower and their skeletal muscles appeared significantly underdeveloped, whereas heart was close to normal size.
We used microarrays in order to compare the transcriptomes in skeletal muscle and heart tissue of 11 days-old TK2 knockout pups with the sames tissues of wild-type pups at the same age.
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| Overall design |
We collected skeletal muscle from the hind limb and hearts of three 11 days-old TK2 knockout and three wild-type pups and extracted total RNA. These RNA samples were used for hybridization in Affymetrix arrays.
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| Contributor(s) |
Paredes JA, Karlsson A |
| Citation(s) |
23341978 |
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| Submission date |
Jun 04, 2012 |
| Last update date |
Apr 18, 2017 |
| Contact name |
João Amorim Paredes |
| E-mail(s) |
joao.paredes@ki.se
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| Organization name |
Karolinska Institute
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| Department |
Laboratory Medicine
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| Lab |
Anna Karlsson
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| Street address |
Karolinska Universitetssjukhuset Huddinge, F68
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| City |
Huddinge |
| State/province |
Stockholm |
| ZIP/Postal code |
14186 |
| Country |
Sweden |
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| Platforms (1) |
| GPL11533 |
[MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA167961 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE38449_RAW.tar |
51.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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