GEO DataSets

(Submitter supplied) We identified BP1026b_II1561 to be an important transcriptional regulator controling late stages of intracellular infection. RNA-seq analysis was performed to further investigate the regulatory network of II1561 regulation. ChIP-seq was also performed under the same conditions.

Organism:

Burkholderia pseudomallei

Type:

Expression profiling by high throughput sequencing

Platform:

GPL32930

2 Samples

Download data: XLSX

(Submitter supplied) We identified BP1026b_II1561 to be an important transcriptional regulator controling late stages of intracellular infection. RNA-seq analysis was performed to further investigate the regulatory network of II1561 regulation. ChIP-seq was also performed under the same conditions.

Organism:

Burkholderia pseudomallei

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL32930

2 Samples

Download data: XLSX

(Submitter supplied) We identified BP1026b_II1046 (SapR) to be an important transcriptional regulator controling surface attachment factor 1 (sap1). RNA-seq analysis was performed to further investigate the regulatory network of SapR regulation.

Organism:

Burkholderia pseudomallei

Type:

Expression profiling by high throughput sequencing

Platform:

GPL32930

6 Samples

Download data: XLSX

(Submitter supplied) B. pseudomallei strain K96243 is sensitive to the drug ceftazidime (CAZ), but has been shown to exhibit transient CAZ tolerance when in a biofilm form. To investigate an observed shift in gene expression profile during ceftazidime (CAZ) tolerance and to better understand the mechanistic aspects of this transient tolerance, RNA-sequencing was performed on B. pseudomallei K96243 from the following three growth states: planktonic-free, biofilm, and planktonic shedding cells. more...

Organism:

Burkholderia pseudomallei K96243

Type:

Expression profiling by high throughput sequencing

Platform:

GPL29815

9 Samples

Download data: FPKM_TRACKING, GTF, XLSX

(Submitter supplied) Burkholderia pseudomallei, the etiological agent of melioidosis in humans and animals, often occupies environmental niches and infection sites characterized by limited concentrations of oxygen. Versatile genomic features enable this pathogen to maintain its physiology and virulence under hypoxia, but the crucial regulatory networks employed to switch from oxygen dependent respiration to alternative terminal electron acceptors (TEA) like nitrate, remains poorly understood. more...

Organism:

Burkholderia pseudomallei K96243; Burkholderia pseudomallei

Type:

Expression profiling by genome tiling array

Platform:

GPL16432

44 Samples

Download data: PAIR, TXT

(Submitter supplied) Pathogenic bacteria encounter a variety of stressful host environments during infection. Their responses to meet these challenges protect them from deadly damages and aid in adaption to harmful environments. Bacterial products critical for this protection are therefore interesting as suitable targets for new antimicrobials. To shed light on the complex array of molecular pathways involved in bacterial stress responses we challenged 32 diverse human pathogenic bacteria to 11 infection related stress conditions and catalogued their transcriptomes. more...

Organism:

Borreliella burgdorferi; Pseudomonas aeruginosa; Legionella pneumophila; Klebsiella pneumoniae; Yersinia pseudotuberculosis; Vibrio cholerae; Streptococcus suis; Streptococcus agalactiae; Streptococcus pneumoniae; Mycobacterium tuberculosis; Burkholderia pseudomallei; Campylobacter jejuni; Francisella tularensis; Acinetobacter baumannii; Neisseria gonorrhoeae; Escherichia coli; Shigella flexneri; Aggregatibacter actinomycetemcomitans; Haemophilus influenzae; Staphylococcus aureus subsp. aureus MRSA252; Staphylococcus aureus subsp. aureus MSSA476; Neisseria meningitidis; Staphylococcus epidermidis; Streptococcus pyogenes; Listeria monocytogenes; Salmonella enterica; Achromobacter xylosoxidans; Helicobacter pylori; Enterococcus faecalis

Type:

Expression profiling by high throughput sequencing

30 related Platforms

1122 Samples

Download data: TXT

(Submitter supplied) Prokaryotic cell transcriptomics have been limited to mixed or sub-population dynamics and individuality of cells within heterogeneous populations. This significantly hampers further knowledge into spatiotemporal and stage-specific processes of prokaryotic cells within complex environments. Herein, we developed a ‘TRANSITomic’ approach to profile transcriptomes of single Burkholderia pseudomallei (Bp) cells as they transit through host cell infection at defined stages, yielding pathophysiological insights. more...

Organism:

Burkholderia mallei; Burkholderia pseudomallei

Type:

Expression profiling by array

Platform:

GPL29071

9 Samples

Download data: TXT

(Submitter supplied) We report the methylome sequencing and annotation of Burkholderia pseudomallei D286 based on high-throughput profiling using PacBio SMRT technology

Organism:

Burkholderia pseudomallei

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL18301

5 Samples

Download data: TXT

(Submitter supplied) Burkholderia pseudomallei is a soil-dwelling bacterium which has to survive not only under harsh environmental conditions, but also within various hosts where it can cause the infectious disease melioidosis. The ability, to quickly adapt to these different conditions, is based on its huge genome which encodes for complex regulatory networks. Among them are more than 60 genes belonging to the group of LysR-type transcriptional regulators (LTTRs). more...

Organism:

Burkholderia pseudomallei; Burkholderia pseudomallei K96243

Type:

Expression profiling by array

Platform:

GPL16432

6 Samples

Download data: PAIR, TXT

(Submitter supplied) We report the transcriptome of Burkholderia pseudomallei type VI secretion regulator TctR mutant grown in rich media compared to wild type. The RNA-seq studies confirmed the role of TctR as a negative regulator of T6SS-2, a positive regulator of T6SS-6 and suggest a potential role in regulation of the T6SS-3 and T6SS-4 gene clusters.

Organism:

Burkholderia pseudomallei

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24097

8 Samples

Download data: TXT

(Submitter supplied) Burkholderia pseudomallei  is the causative agent of melioidosis which is endemic to Southeast Asia and Northern Australia. It is a Gram-negative soil and water bacterium that represents a potential bioterrorism threat. Colony morphology variation is a remarkable feature in primary clinical cultures of B. pseudomallei. Differences in expression of several potential virulence and survival genes were believed to be associated with B. more...

Organism:

Burkholderia pseudomallei; Burkholderia pseudomallei K96243

Type:

Expression profiling by array

Platform:

GPL18120

16 Samples

Download data: TXT

(Submitter supplied) Objectives: The Burkholderia pseudomallei bprR and bprS genes are predicted to encode the response regulator and sensor kinase components respectively of a two component signal transduction system. Inactivation of either single component of this two component signal transduction system led to attenuation of B. pseudomallei virulence and also reduced motility. However, inactivation of both components resulted in wild-tpe virulence and motility. more...

Organism:

Burkholderia pseudomallei K96243

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21459

12 Samples

Download data: CSV

(Submitter supplied) We report the application of single-molecule-based sequencing technology for high-throughput profiling of DNA methylations in Burkholderia pseudomallei.

Organism:

Burkholderia pseudomallei

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL18301

2 Samples

Download data: CSV

(Submitter supplied) The gene expression profiles were investigated and compared in spleen, lungs and liver of susceptible (BALB/c) and resistant (C57BL/6) hosts to identify genes participated in survival and virulence functions encoded in the B. pseudomallei genome. Subsequently, genes with unknown function and located with virulence gene clusters or suspected to be transcription regulator were selected for a novel virulence gene investigation

Organism:

Burkholderia mallei; Burkholderia pseudomallei; Burkholderia pseudomallei K96243

Type:

Expression profiling by array

Platform:

GPL17789

7 Samples

Download data: GPR

(Submitter supplied) This study describes the global transcriptional changes upon deletion of a hypothetical gene BPSS1356. The BPSS1356 deletion strain of B. pseudomallei was generated via homologous recombination. Global gene expression profiling of wild type and ∆BPSS1356 mutant strains was performed to elucidate of biological functions of BPSS1356.

Organism:

Burkholderia pseudomallei K96243

Type:

Expression profiling by array

Platform:

GPL18120

6 Samples

Download data: TXT

(Submitter supplied) Bacterial transcriptomes are dynamic, context-specific and condition-dependent. Infection by the soil bacterium, Burkholderia pseudomallei, causes melioidosis, an often fatal infectious disease of humans and animals. Possessing a large multi-chromosomal genome, B. pseudomallei is able to persist and survive in a multitude of environments. To obtain a comprehensive overview of B. pseudomallei expressed transcripts, we initiated whole-genome transcriptome profiling covering a broad spectrum of conditions and exposures – a so-called “condition compendium”. more...

Organism:

Burkholderia pseudomallei K96243; Burkholderia pseudomallei; Burkholderia pseudomallei Bp22

Type:

Expression profiling by genome tiling array

Platform:

GPL16432

332 Samples

Download data: PAIR

(Submitter supplied) To use whole genome microarrays to compare the differences in genome contents of 5 B. pseudomallei isolated from clinical specimens and environmental sample with B. pseudomallei K96243 reference strain and reveals variable patterns of Genomic Islands (GIs) Keywords: Comparative genomic hybridization

Organism:

Burkholderia mallei; Burkholderia pseudomallei

Type:

Genome variation profiling by array

Platform:

GPL9800

5 Samples

Download data: GPR

(Submitter supplied) This study reports the expression profile of intracellular B. pseudomallei following infection of human macrophage-like U937 cells. The transcriptome of intracellular B. pseudomallei harvested from macrophage cells over an infection period of 6 hr (1, 2, 4 and 6 hr post-infection) were compared to in vitro grown bacteria to identify genes whose expression is altered in response to intracellular growth.

Organism:

Burkholderia pseudomallei K96243; Burkholderia pseudomallei

Type:

Expression profiling by array

Platform:

GPL13233

15 Samples

Download data: TXT

(Submitter supplied) Array-CGH analysis and Burkholderia pseudomallei isolates pre and post ceftazidime relapse.

Organism:

Burkholderia pseudomallei K96243; Burkholderia pseudomallei

Type:

Genome variation profiling by genome tiling array

Platform:

GPL11276

6 Samples

Download data: PAIR

(Submitter supplied) Gene expression profiles of human cell (THP-1) lines exposed to a novel Daboiatoxin (DbTx) isolated from Daboia russelli russelli, and specific cytokines and inflammatory pathways involved in acute infection caused by Burkholderia pseudomallei. Keywords: Melioidosis, Burkholderia pseudomallei, Daboiatoxin, Cytokines, Inflammation.

Organism:

Burkholderia pseudomallei; Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

15 Samples

Download data: CEL, CHP