Similar studies for GEO DataSets (Select 790) - GEO DataSets

Select item 7901.

Keratinocyte differentiation promoted by Notch1 signaling

Comparison of gene expression in keratinocytes from embryos at 15.5 days of gestation to that from 2 day newborns infected with an adenovirus expressing a constitutively activate Notch1. Results indicate that Notch1 promotes differentiation in part through caspase 3.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 development stage, 3 infection sets

Platform:: GPL81
Series:: GSE1569
4 Samples

Download data

DataSet

Accession:: GDS790

ID:: 790

Select item 2000015692.

Keratinocytes in embryos and newborns, and Notch1 expression in newborns

(Submitter supplied) Comparison between pattern of gene expression in uncultured keratinocytes derived from the epidermis of embryonic mice (E15.5) versus newborn mice and comparison between pattern of gene expression in primary keratinocytes derived from newborn mice plus/minus activated Notch1 expression. Keywords = mouse Keywords = keratinocyte Keywords = skin Keywords = embryonic development. Keywords: other

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS790
Platform:: GPL81
4 Samples

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Series

Accession:: GSE1569

ID:: 200001569

Select item 2000898843.

DLX3 binding sites in Supabasal Keratinocytes

(Submitter supplied) DLX3 is a homeodomain transcription factor involved in epidermal differentiation. Here we investigated the distribution of DLX3 DNA binding sites in suprabasal differentiating keratinocytes using ChIP-seq.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
3 Samples

Download data: BED, BEDGRAPH

Series

Accession:: GSE89884

ID:: 200089884

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001442414.

Stagewise keratinocyte differentiation from human embryonic stem cells by defined signal transduction modulators

(Submitter supplied) we use human embryonic stem cells to demonstrate that epidermal ectoderm and subsequent keratinocyte cell fate can be determined step by step under the regulation of defined factors. We show the global gene expression profiles clustered according to the differentiation stages . We also found the human keratinocyte specific gene expression according to the differentiation stages.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
7 Samples

Download data: TXT

Series

Accession:: GSE144241

ID:: 200144241

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000068675.

Expression data in the absence of Notch1 in hair follicles

(Submitter supplied) Notch1 deficient hair matrix keratinocytes have lower mitotic rates, resulting in smaller follicles with fewer cells. In addition, the ratio of melanocytes to keratinocytes is greatly reduced. Microarray was performed to study downstream mechanism of Notch1-deficiency Keywords: genetic modification

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2848
Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE6867

ID:: 200006867

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 28486.

Notch1 deficiency effect on hair follicles

Analysis of Notch1-deficient hair follicles from the skin of transgenic animals. Results provide insight into the molecular mechanisms underlying the lowered mitotic index and increased apoptosis observed in Notch1-deficient hair follicles.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 other, 2 strain sets

Platform:: GPL1261
Series:: GSE6867
6 Samples

Download data: CEL

DataSet

Accession:: GDS2848

ID:: 2848

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000052297.

Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation

(Submitter supplied) Notch signaling promotes commitment of keratinocytes to differentiation and suppresses tumorigenesis. p63, a p53 family member, has been implicated in establishment of the keratinocyte cell fate and/or maintenance of epithelial self-renewal. Here we show that p63 expression is suppressed by Notch1 activation in both mouse and human keratinocytes through a mechanism independent of cell cycle withdrawal and requiring down-modulation of selected interferon-responsive genes, including IRF7 and/or IRF3. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL571 GPL339
4 Samples

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Series

Accession:: GSE5229

ID:: 200005229

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Select item 2002018238.

A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing

(Submitter supplied) The mitogen-activated protein kinase kinase (MEK) kinase 1 (MEKK1), also known as MAP3K1, mediates activin B (ActB) signals required for eyelid epithelium morphogenesis during mouse fetal development. The present study investigates the role of MEKK1 in epithelial wound healing, another activin-regulated biological process. In a skin wound model, injury markedly stimulates MEKK1 expression and activity, which are in turn required for the expression of genes involved in extracellular matrix (ECM) homeostasis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL32220
12 Samples

Download data: GPR, TXT

Series

Accession:: GSE201823

ID:: 200201823

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000951999.

GRHL3 binding and the enhancer landscape are reorganized during transitions between different functional states of epidermal keratinocytes [ChIP-seq]

(Submitter supplied) The genomic mechanisms underlying progressive, irreversible cell lineage commitments and differentiation, which include large scale chromatin re-organization, transcription factor binding, and chromatin modifications, have been well defined. However, we know little about the chromatin changes during transitions between transient cell states such as cell migration. Here we demonstrate the formation of unique complements of typical enhancers and super-enhancers as human progenitor keratinocytes either differentiate or migrate. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
2 Samples

Download data: BED

Series

Accession:: GSE95199

ID:: 200095199

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009447110.

GRHL3 binding and the enhancer landscape are reorganized during transitions between different functional states of epidermal keratinocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL6244
16 Samples

Download data: BED, CEL

Series

Accession:: GSE94471

ID:: 200094471

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009446711.

GRHL3 binding and the enhancer landscape are reorganized during transitions between different functional states of epidermal keratinocytes [siREST-migration]

(Submitter supplied) The genomic mechanisms underlying progressive, irreversible cell lineage commitments and differentiation, which include large scale chromatin re-organization, transcription factor binding, and chromatin modifications, have been well defined. However, we know little about the chromatin changes during transitions between transient cell states such as cell migration. Here we demonstrate the formation of unique complements of typical enhancers and super-enhancers as human progenitor keratinocytes either differentiate or migrate. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
4 Samples

Download data: CEL

Series

Accession:: GSE94467

ID:: 200094467

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009446612.

GRHL3 binding and the enhancer landscape are reorganized during transitions between different functional states of epidermal keratinocytes [siREST-proliferation]

(Submitter supplied) The genomic mechanisms underlying progressive, irreversible cell lineage commitments and differentiation, which include large scale chromatin re-organization, transcription factor binding, and chromatin modifications, have been well defined. However, we know little about the chromatin changes during transitions between transient cell states such as cell migration. Here we demonstrate the formation of unique complements of typical enhancers and super-enhancers as human progenitor keratinocytes either differentiate or migrate. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
4 Samples

Download data: CEL

Series

Accession:: GSE94466

ID:: 200094466

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009446513.

GRHL3 binding and the enhancer landscape are reorganized during transitions between different functional states of epidermal keratinocytes [siGRHL3-migration]

(Submitter supplied) The genomic mechanisms underlying progressive, irreversible cell lineage commitments and differentiation, which include large scale chromatin re-organization, transcription factor binding, and chromatin modifications, have been well defined. However, we know little about the chromatin changes during transitions between transient cell states such as cell migration. Here we demonstrate the formation of unique complements of typical enhancers and super-enhancers as human progenitor keratinocytes either differentiate or migrate. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
6 Samples

Download data: CEL

Series

Accession:: GSE94465

ID:: 200094465

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008619314.

GRHL3 chromatin binding and the super-enhancer landscape are reorganized in different functional states of epidermal keratinocytes

(Submitter supplied) While the genomic mechanisms underlying progressive, irreversible cell lineage commitments are well-studied, we know little about the chromatin changes during transient cell states such as cell migration. Interestingly, a large number of SEs in NHEK-D and NHEK-M overlap genes encoding transcription factors with important roles in promotion of epidermal differentiation, including GRHL3, TP63, RUNX1, NOTCH3 and FOS. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL22382
56 Samples

Download data: TXT

Series

Accession:: GSE86193

ID:: 200086193

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007669115.

GRHL3 regulates the chromatin state during epidermal differentiation

(Submitter supplied) The process of differentiation is tightly controlled, and such complex coordination of gene expression requires many layers of regulation. One such mechanism of regulation occurs through distal genomic regions called enhancers, which are believed to act as concentrating sites for transcription factors, like GRHL3, and other regulators, forming loops to contact promoters and enhance transcription. Active enhancers have been shown to have high levels of H3K4me1 and H3K27ac modified nucleosomes, with low levels of H3K4me3, while poised developmental enhancers have been shown to have H3K27me3 in place of H3K27ac. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
14 Samples

Download data: BED

Series

Accession:: GSE76691

ID:: 200076691

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006807516.

Genome-wide analysis of histone modifications H3K27ac, H3K4me3, and H3K4me1 in migrating primary human epidermal keratinocytes (NHEK)

(Submitter supplied) The epidermis is a stratified squamous epithelium that serves to protect the body from dehydration, absorption of chemicals, and invasion of pathogens. It derives from the surface ectoderm during the later stages of mammalian embryonic development. In a stratified squamous epithelium cells of the basal layer contain proliferative potential. As they divide and move upward in the tissue, they progressively differentiate, and activate the gene expression program required to create a barrier; eventually, cells in the uppermost layer are sloughed off from the surface of the epidermis. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
8 Samples

Download data: TXT

Series

Accession:: GSE68075

ID:: 200068075

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014466917.

DNA methylation profiling of proliferating and differentiating keratinocytes

(Submitter supplied) The epidermal compartment of the skin is regenerated constantly by proliferation of epidermal keratinocytes. Differentiation of a subset of these keratinocytes allows the epidermis to retain its barrier properties. Regulation of keratinocyte fate – whether to remain proliferative or terminally differentiate – is complex and not fully understood. The objective of our study was to assess if DNA methylation changes contribute to the regulation of keratinocyte fate. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL21145
10 Samples

Download data: IDAT, TXT

Series

Accession:: GSE144669

ID:: 200144669

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013568018.

IRF2 is a master regulator of human keratinocyte stem cell fate

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21697 GPL16791 GPL18573
40 Samples

Download data: WIG

Series

Accession:: GSE135680

ID:: 200135680

PubMed Full text in PMC Similar studies

Select item 20013567919.

IRF2 is a master regulator of human keratinocyte stem cell fate [RNA-seq]

(Submitter supplied) Resident adult epithelial stem cells maintain tissue homeostasis by balancing self-renewal and provision of differentiated cells. Human epidermal keratinocytes retain stem cell potential in vitro but this is highly variable and lost over time suggesting extrinsic and intrinsic regulation. Transcription factor-controlled regulatory circuitries govern cell identity and are sufficient to induce pluripotency or transdifferentiate cell types. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: TXT

Series

Accession:: GSE135679

ID:: 200135679

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20013567720.

IRF2 is a master regulator of human keratinocyte stem cell fate [ChIPmentation]

(Submitter supplied) Resident adult epithelial stem cells maintain tissue homeostasis by balancing self-renewal and provision of differentiated cells. Human epidermal keratinocytes retain stem cell potential in vitro but this is highly variable and lost over time suggesting extrinsic and intrinsic regulation. Transcription factor-controlled regulatory circuitries govern cell identity and are sufficient to induce pluripotency or transdifferentiate cell types. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21697
8 Samples

Download data: WIG

Series

Accession:: GSE135677

ID:: 200135677

PubMed Full text in PMC Similar studies SRA Run Selector

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