GEO DataSets

Analysis of adult worms fed live lactic acid bacteria (LAB) Lactobacillus rhamnosus CNCM I-3690 or CNCM I-4317 for 10 days. L. rhamnosus CNCM I-3690 protects against oxidative stress and increases lifespan in worms. Results provide insight into probiotic LAB-induced oxidative stress protection.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL200

Series:

GSE42192

9 Samples

Download data: CEL

(Submitter supplied) Numerous studies have shown that resistance to oxidative stress is crucial to stay healthy and to reduce the adverse effects of aging. Accordingly, nutritional interventions using antioxidant food-grade compounds or food products are currently an interesting option to help improve health and quality of life in the elderly. Live lactic acid bacteria (LAB) administered in food, such as probiotics, may be good antioxidant candidates. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Datasets:

GDS4566 GDS5006

Platform:

GPL200

18 Samples

Download data: CEL

Analysis of young worms fed live lactic acid bacteria (LAB) Lactobacillus rhamnosus CNCM I-3690 or CNCM I-4317 for 3 days. L. rhamnosus CNCM I-3690 protects against oxidative stress and increases lifespan in worms. Results provide insight into probiotic LAB-induced oxidative stress protection.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL200

Series:

GSE42192

9 Samples

Download data: CEL

(Submitter supplied) We have discovered rifampicin as a glycation inhibitor, which increases life span in C elegans. In order to understand the mechanism of rifampicin action, microarray analysis was performed to study the changes in gene expression brought about by the drug.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL200

4 Samples

Download data: CEL

(Submitter supplied) In the present study, we investigated the effect of CBM 588 on lifespan and multiple-stress resistance using Caenorhabditis elegans as a model animal. When adult C. elegans were fed a standard diet of Escherichia coli OP50 or CBM 588, the lifespan of the animals fed CBM 588 was significantly longer than that of animals fed OP50. Moreover, the worms fed CBM 588 were more resistant to certain stressors, including infections with pathogenic bacteria, UV irradiation, and the metal stressor Cu2+. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13657

2 Samples

Download data: TXT

(Submitter supplied) One of the most important issues in the study of aging is to discover compounds with longevity-promoting activity and to unravel their underlying mechanisms. Queen honey bees are continuously fed royal jelly (RJ), and they live more than 10 times longer than hive workers, derived from the same diploid genome, which are fed it only for a short period of time during their larval stages. Therefore, RJ is likely to contain longevity-promoting agents for queens. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL11346

6 Samples

Download data: TXT

(Submitter supplied) isp-1;sod double mutants have decreased lifespan, increased resistance to oxidative stress and slow physiologic rates. We performed RNA sequencing to compare gene expression between isp-1 mutants and isp-1;sod-3 and isp-1;sod-5 double mutants

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19757

12 Samples

Download data: TXT

(Submitter supplied) We analyzed RNA-seq data from C. elegans on six bacterial diets, 3 E. coli diets (OP50, HT115, HB101) found in the laboratory setting and 3 found in C. elegans natural environment (Methylobacterium, Xanthomonas, Sphingomonas). We compared gene expression between L4 worms on the OP50 diet to the other 5 bacterial diets. We found that diet influences many gene expression changes, leading to genes being both up regulated and down regulated in a diet-dependent manner.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26672

24 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL200

18 Samples

Download data: CEL

(Submitter supplied) Analysis of wildtype (N2) C. elegans fed different diets: E. coli OP50, E. coli HT115 and Comamonas DA1877 Dietary composition has major effects on physiology. Here we show that developmental rate, reproduction and lifespan are altered in C. elegans fed Comamonas DA1877 relative to those fed a standard E. coli OP50 diet. We identify a set of genes that change in expression in response to this diet, and use the promoter of one of these (acdh-1) as a dietary sensor. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL200

9 Samples

Download data: CEL

(Submitter supplied) Analysis of wildtype (N2) C. elegans fed different diets: E. coli OP50, Comamonas DA1877, and Diluted Comamonas (1:1000 Comamonas DA1877:E. coli OP50) Dietary composition has major effects on physiology. Here we show that developmental rate, reproduction and lifespan are altered in C. elegans fed Comamonas DA1877 relative to those fed a standard E. coli OP50 diet. We identify a set of genes that change in expression in response to this diet, and use the promoter of one of these (acdh-1) as a dietary sensor. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL200

9 Samples

Download data: CEL