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Links from GEO DataSets

Items: 20

1.
Full record GDS2078

Estren effect on the estrogen receptor alpha null uterus: time course

Analysis of uteri from adult ovariectomized estrogen receptor alpha (ERalpha) null mutants treated with estren, estradiol, or 19-nortestosterone for 2 or 24 hours. Estren is a synthetic steroid. Results provide insight into the dependence of gene responses induced by estren in the uterus on ERalpha.
Organism:
Mus musculus
Type:
Expression profiling by array, log10 ratio, 3 agent, 2 time sets
Platform:
GPL891
Series:
GSE4615
10 Samples
Download data: TIFF, TXT
DataSet
Accession:
GDS2078
ID:
2078
2.

Estren Behaves as a Weak Estrogen Rather than a Non-genomic Selective Activator in the Mouse Uterus

(Submitter supplied) A proposed membrane-mediated mechanism of rapid non genomic response to estrogen has been the intense focus of recent research. Estren (Es), a synthetic steroid, is reported to act selectively through a rapid membrane-mediated pathway, rather than through the classical nuclear estrogen receptor (ER)-mediated pathway, to maintain bone density in ovaierectomized mice without uterotropic effects. To further evaluate the mechanism and physiological effects of Es we studied responses in adult ovariectomized mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS2077 GDS2078
Platform:
GPL891
22 Samples
Download data: TIFF, TXT
Series
Accession:
GSE4615
ID:
200004615
3.
Full record GDS2077

Estren effect on the uterus: time course

Analysis of uteri from adult ovariectomized animals treated with estren, estradiol, dihydrotestosterone, or 19-nortestosterone for 2 or 24 hours. Estren is a synthetic steroid. Results provide insight into the molecular and physiological effects of estren on the uterus.
Organism:
Mus musculus
Type:
Expression profiling by array, log10 ratio, 4 agent, 2 time sets
Platform:
GPL891
Series:
GSE4615
12 Samples
Download data: TIFF, TXT
DataSet
Accession:
GDS2077
ID:
2077
4.

24 hour time course: regulation of uterine genes by estradiol in ovariectomized mice

(Submitter supplied) Using microarray technology, we compared the global expression pattern of uterine RNA from ovariectomized control mice to those of ovariectomized mice treated with estradiol for various intervals between 30 minutes and 24 hours. Keywords: estrogen, uterus, genomic, mouse
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2208
Platform:
GPL891
10 Samples
Download data: TIFF, TXT
Series
Accession:
GSE4664
ID:
200004664
5.
Full record GDS2208

Estradiol effect on the uterus: time course

Expression profiling of uteri from ovariectomized C57BL/6 animals at various time points up to 24 hours following treatment with estradiol (E2). E2 plays a critical role in regulating the growth, differentiation, and secretory function of the uterus.
Organism:
Mus musculus
Type:
Expression profiling by array, log10 ratio, 5 time sets
Platform:
GPL891
Series:
GSE4664
10 Samples
Download data: TIFF, TXT
DataSet
Accession:
GDS2208
ID:
2208
6.

Gene expression signatures in uteri from nuclear and membrane effects of Estradiol on Estrogen receptor ERα

(Submitter supplied) To further study gene expression regulated by 17b-estradiol in uteri, we have employed whole gene microarray profiling to identify genes specifically regulated by the Estrogen receptor ERα localized either at the plasma membrane or in the nucleus. Two mice models have been used, the mice named ERa-AF2° (named AF2_KO and on C57BL6/J background) in which 7 aminoacids have been deleted in the AF2 domain and the mice C451A-ERa (named MISS_KO and on C57BL6/N background) mutated for the C451 into Ala on ERa. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
31 Samples
Download data: TXT
Series
Accession:
GSE53237
ID:
200053237
7.

Potential mechanisms of endocrine disruptors as revealed by uterine gene profile

(Submitter supplied) Females were ovariectomized and injected with sesame oil, estradiol in sesame oil, BPA in sesame oil or HPTE in sesame oil. Uterine tissue was collected after 2 or 24 hours. RNA was analyzed by microarray compare ealry and late responses to a potent and a weak estrogen agaonist.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
20 Samples
Download data: TIFF, TXT
Series
Accession:
GSE24525
ID:
200024525
8.

Uterine Gene Profile of Estriol, a Weak Estrogen

(Submitter supplied) Females were ovariectomized and injected with saline estradiol or estriol. Uterine tissue was collected after 2 or 24 hours. RNA was analyzed by microarray compare ealry and late responses to a potent and a weak estrogen agaonist.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
15 Samples
Download data: TIFF, TXT
Series
Accession:
GSE23241
ID:
200023241
9.

Uterine gene profiles from WT, KIKO (DNA-binding deficient ERα) and aERKO mice treated with estradiol or xenoestrogens

(Submitter supplied) Ovariectomized WT, KIKO (DNA-binding deficient ERα) or αERKO female mice were injected (ip) with saline (vehicle), estradiol (E2; 250 ng), bisphenol A (BPA; 750 µg) or 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE; 750 µg) and uteri were collected after 2 or 24 hours. Uterine profiles were compared and indicated the early (2 hour) responses to E2 were highly correlated to the BPA and HPTE profiles. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL4134 GPL7202
36 Samples
Download data: TIFF, TXT
Series
Accession:
GSE18168
ID:
200018168
10.

Uterine Epithelial Cells Specific Estrogen Receptor alpha-Dependent Gene Expression Profiles in Response to Estrogen

(Submitter supplied) Estrogens stimulate hypertrophy and hyperplasia in the uterus and exert their activity through estrogen receptor α (ERα). A uterine epithelial ERα conditional knockout mouse model (Wnt7aCre+;Esr1f/f or cKO) demonstrated that ERα in the epithelial cells was dispensable for an early uterine proliferative response to 17β-estradiol (E2), but required for subsequent uterine biological responses. We compared the gene expression profile in the uterus after E2 treatment in the cKO samples with WT samples. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5461
Platform:
GPL4134
18 Samples
Download data: TXT
Series
Accession:
GSE53812
ID:
200053812
11.

Estrogen response uterine gene profile in Ex3αERKO

(Submitter supplied) WT and Ex3aERKO females were ovariectomized and injected with saline or estradiol. Uterine tissue was collected after 2 or 24 hours. RNA was analyzed by microarray to determine if the Ex3aERKO mice would lack the residual transcritpional resposnes seen in the previous aERKO model.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
18 Samples
Download data: TIFF, TXT
Series
Accession:
GSE23072
ID:
200023072
12.
Full record GDS5461

17β-estradiol effect on uterus of uterine epithelial ERα conditional knockout model: time course

Analysis of uteri from ovariectomized adult females with uterine epithelial cell-specific ERα deletion following treatment with 17β-estradiol for 2 or 24 hrs. Results provide insight into cell specific actions of ERα in the female reproductive tract.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 genotype/variation, 2 time sets
Platform:
GPL4134
Series:
GSE53812
18 Samples
Download data: TXT
13.

U2OS-ERa, U2OS-ERb, and U2OS-ERab cells treated with 4HT or E2

(Submitter supplied) U2OS-ERa, U2OS-ERb, and U2OS-ERab cells treated with 4HT or E2 Keywords: other
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1094
Platform:
GPL201
45 Samples
Download data: CEL
Series
Accession:
GSE2292
ID:
200002292
14.
Full record GDS1094

Estrogen receptor alpha/beta heterodimer action in response to estrogen and tamoxifen

Expression profiling of U2OS osteosarcoma cell line expressing estrogen receptor/alpha heterodimer after treatment with 10 nM 17beta-estradiol (E2) or 10 nM 4-OH tamoxifen (4HT) for 24 hours. Results provide insight into the role of estrogen receptor/alpha heterodimer in gene regulation.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 agent, 3 genotype/variation sets
Platform:
GPL201
Series:
GSE2292
45 Samples
Download data: CEL
DataSet
Accession:
GDS1094
ID:
1094
15.

Expression data from mouse uteri after ovariectomy and E2 treatment.

(Submitter supplied) 17ß-Estradiol (E2) is well known to be associated with uterine cancer, endometriosis, and leiomyomas. Although insulin-like growth factor I (IGF-I) has been identified as a mediator of the uterotrophic effect of E2 in several studies, this mechanism is still not well understood. In the present study, identification of the genes modulated by a physiological dose of E2, in the uterus, has been done in ovariectomized mice using Affymetrix microarrays. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2638
Platform:
GPL81
6 Samples
Download data: CEL
Series
Accession:
GSE6219
ID:
200006219
16.
Full record GDS2638

Uterus response to 17beta-estradiol: time course

Analysis of uteri from overiectomized animals at various lengths of time up to 24 hours following treatment with 17beta-estradiol (E2). Results provide insight into the molecular basis of the uterotrophic effect induced by a physiological dose of E2.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 6 time sets
Platform:
GPL81
Series:
GSE6219
6 Samples
Download data: CEL
DataSet
Accession:
GDS2638
ID:
2638
17.

Differential Roles of ERα and ERβ in Normal and Neoplastic Development in the Mouse Mammary Gland

(Submitter supplied) The present experiments were performed to determine the roles of estrogen receptors α and β (ERα and ERβ) in normal and neoplastic development in the mouse mammary gland. In wild-type mice, in vivo administration of estradiol (E) + progesterone (P) stimulated mammary ductal growth and alveolar differentiation. Mammary glands from mice in which the ERβ gene has been deleted (βERKO mice) demonstrated normal ductal growth and differentiation in response to E + P. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8063
7 Samples
Download data: TXT
Series
Accession:
GSE62451
ID:
200062451
18.

Affymetrix gene chip analysis for the whole mouse genome transcripts of epithelial and stromal cells from mouse uterine primary co-culture treated with either vehicle or E2

(Submitter supplied) In the present study, to identify potential paracrine factor for the stromal regulation of E2-induced epithelial cell proliferation, we treated epithelial and stromal cell populations of mouse uterine primary co-culture with either oil or E2. Three independent RNA pools prepared for each population were then subjected to the Affymetrix gene chip analysis for the whole mouse genome transcripts. Our data revealed up-regulation of 119 genes and down-regulation of 28 genes in epithelial cell populations and up-regulation of 144 genes and down-regulation of 192 genes in stromal cell population.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE52399
ID:
200052399
19.

Peri- and post-pubertal estrogen exposures of female mice optimize uterine responses later in life

(Submitter supplied) At birth, all female mice, including those that either lack estrogen receptor α (ERα-knockout) or that express mutated forms of ERα (AF2ERKI), have a hypoplastic uterus. However, uterine growth and development that normally accompanies pubertal maturation does not occur in ERα-knockout or AF2ERKI mice, indicating ERα mediated estrogen signaling is essential for this process. Mice that lack Cyp19 (aromatase, ArKO mice), an enzyme critical for estrogen (E2) synthesis, are unable to make E2, and lack pubertal uterine development. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21877
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE147900
ID:
200147900
20.

ER and RNA PolII ChIP-seq in WT and ER mutant mouse uterus

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11002 GPL9250
10 Samples
Download data: BED, BEDGRAPH
Series
Accession:
GSE56501
ID:
200056501
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