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Items: 14

1.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL30845
42 Samples
Download data
Series
Accession:
GSE185724
ID:
200185724

PubMed Full text in PMC Similar studies

2.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats [unfractionated PB]

(Submitter supplied) Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the hematopoietic hierarchy and used functional characterizations to define a purified stem and progenitor cell (HSPC) compartment similar to mouse LIN-/Sca-1+/Kit+ HSPCs or human LIN-/CD34+/CD38lo HSPCs.
Organism:
Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30845
7 Samples
Download data: RDATA
Series
Accession:
GSE202903
ID:
200202903

PubMed Full text in PMC Similar studies SRA Run Selector

3.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats [sorted_BM_PB_THY]

(Submitter supplied) Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the hematopoietic hierarchy and used functional characterizations to define a purified stem and progenitor cell (HSPC) compartment similar to mouse LIN-/Sca-1+/Kit+ HSPCs or human LIN-/CD34+/CD38lo HSPCs.
Organism:
Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30845
5 Samples
Download data: RDATA
Series
Accession:
GSE185723
ID:
200185723

PubMed Full text in PMC Similar studies SRA Run Selector

4.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats [Xeno]

(Submitter supplied) Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the hematopoietic hierarchy and used functional characterizations to define a purified stem and progenitor cell (HSPC) compartment similar to mouse LIN-/Sca-1+/Kit+ HSPCs or human LIN-/CD34+/CD38lo HSPCs.
Organism:
Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30845
8 Samples
Download data: RDATA
Series
Accession:
GSE185722
ID:
200185722

PubMed Full text in PMC Similar studies SRA Run Selector

5.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats [unfractionated LY]

(Submitter supplied) Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the T cell developmental landscape in Naked mole-rats and showed
Organism:
Mus musculus; Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL30845
14 Samples
Download data: RDATA
Series
Accession:
GSE185721
ID:
200185721

PubMed Full text in PMC Similar studies SRA Run Selector

6.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats [unfractionated BM]

(Submitter supplied) Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the hematopoietic hierarchy and used functional characterizations to define a purified stem and progenitor cell (HSPC) compartment similar to mouse LIN-/Sca-1+/Kit+ HSPCs or human LIN-/CD34+/CD38lo HSPCs.
Organism:
Heterocephalus glaber; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL30845
8 Samples
Download data: RDATA
Series
Accession:
GSE185720
ID:
200185720

PubMed Full text in PMC Similar studies SRA Run Selector

7.

Transcriptome sequencing of naked mole rat, Heterocephalus glaber

(Submitter supplied) Deep sequencing of mRNA from naked mole rat
Organism:
Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13793
13 Samples
Download data: BEDGRAPH
Series
Accession:
GSE30337
ID:
200030337

PubMed Full text in PMC Similar studies SRA Run Selector

8.

The human fetal thymus generates effector invariant γδ T cells in a Lin28b-dependent manner

(Submitter supplied) In the mouse thymus, invariant γδ T cells are generated at well-defined times during development and acquire effector functions before exiting the thymus. However, whether such thymic programming can occur in human is not known. Here we analyzed human fetal and post-natal γδ thymocytes and investigated the role of hematopoietic-stem-and-precursor-cells (HSPC) in the generation of human γδ T cells. Unlike post-natal γδ thymocytes, fetal γδ thymocytes were functionally programmed (e.g. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
24 Samples
Download data: CSV
Series
Accession:
GSE128163
ID:
200128163

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

9.

Droplet-based single-cell RNA-sequencing of mouse and naked mole-rat spleen and circulating immune cells, in natural conditions, following lipopolysaccharide (LPS) challanege, and saline control

(Submitter supplied) Single-cell RNA-sequencing was performed in the mouse and naked mole-rat immune systems in order to map and compare their immune cell repertoirs and their cell-specific gene-expression responses to LPS challenge
Organism:
Heterocephalus glaber; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL21103 GPL26775
63 Samples
Download data: CSV
Series
Accession:
GSE132642
ID:
200132642

PubMed Full text in PMC Similar studies SRA Run Selector

10.

TCR signal strength controls thymic differentiation of discrete proinflammatory γδT cell subsetsistinct TCR signal strength requirements in the thymus

(Submitter supplied) The murine thymus produces discrete γδ T cell subsets making either IFN-γ or IL-17, but the role of the TCR in this developmental process remains controversial. Here we generated a non-transgenic and polyclonal model of reduced TCR expression and signal strength selectively on γδ T cells. Mice haploinsufficient for both CD3γ and CD3δ (CD3DH) showed normal αβ thymocyte subsets but specific defects in γδ T cell development, namely impaired differentiation of IL-17-producing embryonic Vγ6+ (but not adult Vγ4+) γδ T cells and a marked depletion of IFN-γ-producing CD122+ NK1.1+ (Vγ1-biased) γδ T cells throughout life. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17400
4 Samples
Download data: CEL
Series
Accession:
GSE71637
ID:
200071637

PubMed Full text in PMC Similar studies Analyze with GEO2R

11.

RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice.

(Submitter supplied) The goal was to find genes which are differentially expressed between the naked mole-rat (Heterocephalus glaber) and the wild-type mice liver tissue. The genes which are most differentially expressed may provide a clue for the remarkable differences between naked mole-rat and mouse in terms of longevity, cancer resistance and adaptation to subterranean environments.
Organism:
Heterocephalus glaber; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13940 GPL9185
2 Samples
Download data: TXT
Series
Accession:
GSE30764
ID:
200030764

PubMed Full text in PMC Similar studies SRA Run Selector

12.

The evolution of the naked mole-rat T cells

(Submitter supplied) The immune system consists of a network of specialized cells and processes that protect the organism from diseases and regulates tissue repair. Natural killer (NK) cells and the αβ and γδ T cells comprise the cytotoxic arm of the immune system and have evolved to detect and eradicate cells infected with pathogens and affected by malignancies, in order to prevent their spread and subsequent tissue damage. more...
Organism:
Mus musculus; Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
4 related Platforms
66 Samples
Download data: MTX, TSV
Series
Accession:
GSE214390
ID:
200214390

PubMed Full text in PMC Similar studies SRA Run Selector

13.

ImmGen Microarray Phase 1

(Submitter supplied) Gene-expression microarray datasets generated as part of the Immunological Genome Project (ImmGen). Primary cells from multiple immune lineages are isolated ex-vivo, primarily from young adult B6 male mice, and double-sorted to >99% purity. RNA is extracted from cells in a centralized manner, amplified and hybridized to Affymetrix 1.0 ST MuGene arrays. Protocols are rigorously standardized for all sorting and RNA preparation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
653 Samples
Download data: CEL
Series
Accession:
GSE15907
ID:
200015907

PubMed Full text in PMC Similar studies Analyze with GEO2R

14.

RNA sequencing of the spleen of naked mole-rat and mouse

(Submitter supplied) Heathly naked mole-rats kept under normal housing conditions harbor either a small or enlarged spleen. The aim of the study is to compare RNAseq of naked mole-rat (NM-R) small and enlarged spleens between them and to compare them with RNAseq of mouse spleen.
Organism:
Heterocephalus glaber; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL21195 GPL17021
9 Samples
Download data: TXT
Series
Accession:
GSE179350
ID:
200179350

PubMed Full text in PMC Similar studies SRA Run Selector

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