Similar studies for GEO DataSets (Select 200141401) - GEO DataSets

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Items: 20

Select item 2001414011.

Loss of tyrosine kinase receptor Ephb2 impairs proliferation and stem cell activity of spermatogonia in culture

(Submitter supplied) In long-term in vitro culture, we report on gene expression in wild-type adult mouse SSCs compared to Ephb2-KO SSCs

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: TXT

Series

Accession:: GSE141401

ID:: 200141401

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000142222.

Gene Expression Profiling of the SSC-Enriched Thy1+ and SSC-Depleted Thy1- Fractions of Prepubertal Mouse Testes

(Submitter supplied) Self-renewal and differentiation of spermatogonial stem cells (SSCs) provides the foundation for testis homeostasis, yet mechanisms that control their functions in mammals are poorly defined. We used microarray transcript profiling to identify specific genes whose expression are augmented in the SSC-enriched Thy1+ germ cell fraction of mouse pup testes. Comparisons of gene expression in the Thy1+ germ cell fraction to the Thy1-depeleted testis cell population identified 202 genes that are expressed 10-fold or higher in Thy1+ cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE14222

ID:: 200014222

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000501433.

Expression data of CD9 positive germ cells from young and aged Sprague Dawley germ cell specific GFP rats

(Submitter supplied) Male fertility and testis function changes with age and so it was sought to determine if these changes are accompanied by changes in gene expression in the spermatogonial cells at the foundation of spermatogenesis A full genome microarray was used to determine if distinct pathways of genes were altered in expression in CD9-positive germ cells with age

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL15084
8 Samples

Download data: TXT

Series

Accession:: GSE50143

ID:: 200050143

Select item 2002221054.

Defining prepubertal primate spermatogonial stem cells to address fertility preservation in prepubertal boys

(Submitter supplied) Antineoplastic treatments for cancer and other non-malignant disorders can result in male long-term or permanent infertility by ablating spermatogonial stem cells (SSCs). Preserving the future fertility of prepubertal patients faced with this prospect cannot rely on sperm banking. SSC transplantation using testicular tissue harvested before sterilizing treatment is a promising approach for restoring fertility, but lack of exclusive biomarkers which can unequivocally identify prepubertal SSCs in any primate species limits the therapeutic potential. more...

Organism:: Macaca mulatta; Papio anubis

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL30489 GPL21120 GPL27943
6 Samples

Download data: MTX, TSV

Series

Accession:: GSE222105

ID:: 200222105

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Select item 2001529305.

10x Genomics single-cell RNA-seq of isolated Adult ID4-EGFP-bright mouse spermatogonia treated with Rapamycin

(Submitter supplied) To reveal distinct transcriptome changes among ID4-EGFP-bright adult mouse spermatogonia associated with mTORC1 activity, single-cell transcriptomes were generated from GFP-bright/CD9-bright spermatogonia from adult mice in three groups: control (untreated), 2 days of Rapamycin treatment (Rapamycin) and 2 days Rapamycin plus 1 day washout (Rapamycin_Release). Based on transplantation studies performed previously, ID4-EGFPbright cells are highly enriched for SSCs. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
3 Samples

Download data: MTX, TSV

Series

Accession:: GSE152930

ID:: 200152930

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Select item 2001078936.

Identification of Glucocorticoid-Induced Leucine Zipper (Gilz) gene targets in undifferentiated spermatogonia

(Submitter supplied) Sustained spermatogenesis in adult males and recovery of fertility following germ cell depletion are dependent on undifferentiated spermatogonia with self-renewal potential. We have previously demonstrated a critical cell-autonomous role for Gilz in spermatogonial stem cell maintainance and spermatogenesis. To identify genes regulated by Gilz in the male germline, we have isolated undifferentiated spermatogonial cells from tamoxifen treated Gilzflox/flox (Control) and Gilzflox/flox UBC-CreER (TAM-KO) mice that will allow identification of genes mis-expressed upon loss of GILZ.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
8 Samples

Download data: TXT

Series

Accession:: GSE107893

ID:: 200107893

PubMed Similar studies SRA Run Selector

Select item 2001266077.

The histone demethylase KDM1A is essential for the maintenance and differentiation of spermatogonial stem cells and progenitors

(Submitter supplied) Little is known of the fundamental processes governed by epigenetic mechanisms in the supplier cells of spermatogenesis, the spermatogonial stem cells (SSCs). The histone H3 lysine demethylase KDM1A is expressed in spermatogonia. We hypothesized that KDM1A serves in transcriptional regulation of SSCs and fertility. Using a conditional deletion of Kdm1a [conditional knockout (cKO)] in mouse spermatogonia, we determined that Kdm1a is essential for spermatogenesis as adult cKO males completely lack germ cells. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: CSV

Series

Accession:: GSE126607

ID:: 200126607

PubMed Similar studies SRA Run Selector

Select item 2000977868.

The juvenile rhesus monkey (Macaca mulatta) testicular transcriptome and differential gene expression associated with the decision of undifferentiated spermatogonia to commit to the differentiation pathway

(Submitter supplied) Goal: To identify the genes associated with the decision of undifferentiated spermatogonia to commit to a pathway of differentiation. Methods: testis mRNA profiles of 10 juvenile wild-type rhesus monkeys (3 vehicle-treated; 6 gonadotropin treated) were generated by deep sequencing, in triplicate and quadruplicate, using Illumina NextSeq500. The sequence reads that passed filters were analyzed at the transcript isoform level with TopHat followed by Cufflinks. more...

Organism:: Macaca mulatta

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21120
10 Samples

Download data: BEDGRAPH, FA, GTF, TXT

Series

Accession:: GSE97786

ID:: 200097786

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Select item 2001305549.

CDK2 kinase activity is a regulator of male germ cell fate

(Submitter supplied) The ability of men to remain fertile throughout their lives depends upon establishment of a spermatogonial stem cell (SSC) pool from gonocyte progenitors, and also maintaining the proper balance between SSC renewal and spermatogenic differentiation throughout life. Depletion of SSCs causes infertility with a Sertoli Cell Only Syndrome (SCOS) phenotype. We previously created a mouse strain in which an inhibitory phosphorylation site (Tyr15) of Cyclin-dependent kinase 2 (Cdk2) was altered. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
3 Samples

Download data: MTX, TSV

Series

Accession:: GSE130554

ID:: 200130554

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016006310.

FGF9 Promotes Mouse Spermatogonial Stem Cell Proliferation Mediated by p38 MAPK Signaling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
18 Samples

Download data: LOOM, MTX, TSV

Series

Accession:: GSE160063

ID:: 200160063

PubMed Full text in PMC Similar studies

Select item 20016006211.

FGF9 Promotes Mouse Spermatogonial Stem Cell Proliferation Mediated by p38 MAPK Signaling [bulk RNA-seq]

(Submitter supplied) Objectives: Fibroblast growth factor 9 (FGF9) is expressed by somatic cells in the seminiferous tubules, yet little information exists about its role in regulating spermatogonial stem cells (SSCs). Materials and Methods: Fgf9 overexpression lentivirus was injected into mouse testes, and PLZF immunostaining was performed to investigate the effect of FGF9 on spermatogonia in vivo. Effect of FGF9 on SSCs was detected by transplanting cultured germ cells into tubules of testes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
16 Samples

Download data: CSV

Series

Accession:: GSE160062

ID:: 200160062

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016006112.

FGF9 Promotes Mouse Spermatogonial Stem Cell Proliferation Mediated by p38 MAPK Signaling [single-cell RNA-seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
2 Samples

Download data: LOOM, MTX, TSV

Series

Accession:: GSE160061

ID:: 200160061

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Select item 20001899713.

Transcriptional profiling of testicular biopsies with Sertoli-cell-only and spermatogonial presence

(Submitter supplied) The aim of the study was to identify in vivo spermatogonial gene expression within the context of their biological niche. Identification of spermatogonial genes was done by t-testing on the replicates of Score 3 (Spermatogonia) and Score 2 (SCO) testicular biopsies.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE18997

ID:: 200018997

Select item 20018289714.

Lovastatin Promotes the Self-renewal of Murine and Primate Spermatogonial Stem Cells

(Submitter supplied) The spermatogonial stem cells (SSCs) niche is critical for SSC maintenance and the subsequent spermatogenesis. Numerous reproductive hazards impair the SSC niche, thereby result in aberrant SSC self-renewal and male infertility. However, promising agents targeting the impaired SSC niche to promote SSC self-renewal are still limited. Here, we screen out and assess the effects of Lovastatin on the self-renewal of mouse spermatogonial stem cells (mSSCs). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
6 Samples

Download data: TXT

Series

Accession:: GSE182897

ID:: 200182897

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Select item 20008342215.

Methyl-seq and ChIP-seq analyses of TSPAN8-high and TSPAN8-low subpopulations of ID4-EGFP+ undifferentiated spermatogonia

(Submitter supplied) P6 ID4-EGFP+ undifferentiated spermatogonia stained robustly (high) or weakly (low) for TSPAN8 were isolated by FACS.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL17021 GPL19057
10 Samples

Download data: TXT, XLSX

Series

Accession:: GSE83422

ID:: 200083422

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008331116.

RNA-seq analyses of ID4-EGFP+ undifferentiated spermatogonia and sorted subpopulations.

(Submitter supplied) P6 ID4-EGFP+ undifferentiated spermatogonia, including those stained robustly (high) or weakly (low) for TSPAN8 were isolated by FACS.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
9 Samples

Download data: CSV

Series

Accession:: GSE83311

ID:: 200083311

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20023648817.

Whole transcriptome RNAseq analysis of adult Inha WT and KO normal testis (N), tumour associated tubules (TAT) and tumour regions (TM).

(Submitter supplied) We performed bulk RNA-Seq on testes from adult Inha WT and KO mice (lacking the inhibin a gene).

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
17 Samples

Download data: XLSX

Series

Accession:: GSE236488

ID:: 200236488

PubMed Full text in PMC Similar studies

Select item 20012965918.

Induced expression of PD-L1 in spermatogonial stem cells by self-renewal division allows allogeneic offspring production

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL6246 GPL19057
20 Samples

Download data: CEL

Series

Accession:: GSE129659

ID:: 200129659

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012965819.

Induced expression of PD-L1 in spermatogonial stem cells by self-renewal division allows allogeneic offspring production [Sequencing]

(Submitter supplied) Testis immune privilege is thought to be mediated by somatic cells. However, it is not strong enough to protect allogeneic spermatogonial stem cells (SSCs) transplanted into the seminiferous tubules. Here we report successful production of allogeneic offspring by inducing PD-L1 in SSCs. Activation of self-renewal division induced PD-L1 and B7-H3 expression in cultured SSCs, which produced sperm after allogeneic transplantation. more...