GEO DataSets

(Submitter supplied) Goal of the experiment: To examine differential gene expression in the iliac arteries of cynomolgous monkeys in the presence of small, medium, or large atherosclerotic plaque. Brief description of the experiment: Objective: To examine global gene expression patterns in the iliac arteries of monkeys containing small, medium, or large atherosclerotic plaque. Design: The left iliac artery of 12 ovariectomized cynomolgous monkeys on a high fat diet for 8 years was biopsied. more...

Organism:

Homo sapiens; Macaca fascicularis

Type:

Expression profiling by array

Platform:

GPL2895

12 Samples

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(Submitter supplied) Objective: To examine the effect of estradiol on gene expression in the monkey iliac arteries. Design: Eight ovariectomized cynomolgus monkeys were on a high fat diet for 6.5 years. The left iliac artery was biopsied before randomization to estradiol (1 mg Estrace® per day, n=4) or vehicle (n=4) for 8 months. The right iliac artery was obtained at necropsy. Gene expression in the iliac arteries in response to estradiol was determined by DNA microarray and confirmed by real time RT-PCR. more...

Organism:

Macaca fascicularis; Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2895

8 Samples

Download data: TXT

(Submitter supplied) Objective: To examine the effects of the phytoestrogen metabolite, equol, on gene expression in the monkey iliac artery. Design: Eight ovariectomized cynomolgus monkeys were on a high fat diet for 6.5 years. The left iliac artery was biopsied prior to randomization to equol (0.0237 g/100 g chow, n=4) or vehicle (n=4) for 8 months. The right iliac artery was obtained at necropsy. Gene expression in the iliac arteries in response to equol was determined by DNA microarray and confirmed by real time RT-PCR. more...

Organism:

Homo sapiens; Macaca fascicularis

Type:

Expression profiling by array

Platform:

GPL2895

8 Samples

Download data: TXT

(Submitter supplied) Phenotypic heterogeneity among arterial ECs is particularly relevant to atherosclerosis since the disease occurs predominantly in major arteries, which vary in their atherosusceptibility. To explore EC heterogeneity, we used DNA microarrays to compare gene expression profiles of freshly harvested porcine coronary and iliac artery ECs. We demonstrate that in vivo the endothelial transcriptional profile of a coronary artery (the right coronary artery) is intrinsically different from that of a major conduit vessel (the external iliac artery), and that this difference is consistent with former vessel being more prone to atherosclerosis. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3461

12 Samples

Download data: GPR

(Submitter supplied) Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit a marked difference in their susceptibility to atherosclerosis and the arterial wall has proven to be a source of the difference in atherosclerosis susceptibility. Genome-wide gene expression analysis was conducted in aortic walls of the two strains. Total RNA was extracted from aortas of 6-week-old female B6 and C3H apoE-deficient (apoE-/-) mice fed a chow or Western diet. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

4 Samples

Download data: CEL

(Submitter supplied) We used microarray analyses in human atherosclerotic plaque to identify network imply in the maintenance and progression of the pathology. To obtain a wide dynamic range we used the scanning method proposed by Skibbe et al. (Bioinformatics. 2006;22(15):1863-1870) performing three subsequent scansions for the same slide. We performed before low than medium and high PMT and laser intensity scansions to permit to detect differences in expression of high expressed genes from the first scansion and from low expressed genes from the last scansion. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS3696 GDS3697 GDS3698

Platform:

GPL6647

66 Samples

Download data: TXT

Analysis of 8 atherosclerotic LAD coronaries presenting at least 75% stenosis and calcified plaques. Atherosclerosis affects aorta, coronary, carotid, and iliac arteries more frequently than any other vessel. Results provide insight into molecular networks underlying the atherosclerotic condition.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 8 individual sets

Platform:

GPL6647

Series:

GSE11138

22 Samples

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Analysis of 8 atherosclerotic LAD coronaries presenting at least 75% stenosis and calcified plaques. Atherosclerosis affects aorta, coronary, carotid, and iliac arteries more frequently than any other vessel. Results provide insight into molecular networks underlying the atherosclerotic condition.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 8 individual sets

Platform:

GPL6647

Series:

GSE11138

22 Samples

Download data

Analysis of 8 atherosclerotic LAD coronaries presenting at least 75% stenosis and calcified plaques. Atherosclerosis affects aorta, coronary, carotid, and iliac arteries more frequently than any other vessel. Results provide insight into molecular networks underlying the atherosclerotic condition.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 8 individual sets

Platform:

GPL6647

Series:

GSE11138

22 Samples

Download data

(Submitter supplied) Tissue samples have been isolated during corornary artery by-pass grafting (CABG)surgery from the atheroscelrotic arterial wall (AAW, aortic root puncture for proxmal ligation of by-pass vessel), non-atherosclertoci arterial wall (NAAW, distal part of mammary artery used a graft for LAD), liver, skeletal muscle (Recturs m), pericardial mediastinal visceral fat) in CAD patients. Carotid lesions samples from 25 validation patients. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

278 Samples

Download data: CEL

(Submitter supplied) Increased monocyte adhesion to dysfunctional endothelial cells (ECs) orchestrated by chemokines plays an important role in arterial inflammation during atherosclerosis. Endothelial microRNAs (miRNAs) processed by the RNase Dicer1 determine the phenotype of ECs by posttranscriptional regulation of gene expression. However, the impact of endothelial miRNAs on endothelial inflammation and atherosclerosis is currently unclear. more...

Organism:

Mus musculus

Type:

Expression profiling by RT-PCR

Platform:

GPL18082

6 Samples

Download data: TXT

(Submitter supplied) Increased monocyte adhesion to dysfunctional endothelial cells (ECs) orchestrated by chemokines plays an important role in arterial inflammation during atherosclerosis. Endothelial microRNAs (miRNAs) processed by the RNase Dicer1 determine the phenotype of ECs by posttranscriptional regulation of gene expression. However, the impact of endothelial miRNAs on endothelial inflammation and atherosclerosis is currently unclear. more...

Organism:

Mus musculus

Type:

Expression profiling by RT-PCR

Platform:

GPL18082

6 Samples

Download data: TXT

(Submitter supplied) Tertiary lymphoid organs (TLOs) emerge in response to nonresolving inflammation but their roles in adaptive immunity remain unknown. Here, we explored artery TLOs (ATLOs) to delineate atherosclerosis T cell responses in apoe-/- mice during aging. Though the T cell repertoire showed systemic age-associated contractions in size and modifications in subtype composition and activation, wt and apoe-/- mice were equally affected. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL8321 GPL1261

65 Samples

Download data: CEL, EXP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

44 Samples

Download data: CEL

(Submitter supplied) Identification of differential gene expression in blood vessels from patients with uremia

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

10 Samples

Download data: CEL

(Submitter supplied) Identification of differential gene expression in blood vessels from patients with uremia

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

34 Samples

Download data: CEL

(Submitter supplied) Expression profiles in aortas isolated from mouse strains C3H.2/HeJ and C57.2Bl/6. Mice were were either on a high fat diet or normal diet for 0, 4, 10, 24, or 40 weeks. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS735

Platform:

GPL891

54 Samples

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Comparison of gene expression in aortas of C57BL/6 and C3H/HeJ fed identical high fat diets at 0, 4, 8, 24, and 40 weeks. C57BL/6 has a greater tendency than C3H/HeJ to develop atherosclerotic aortic lesions when both fed identical high fat diets.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 2 growth protocol, 2 strain, 5 time sets

Platform:

GPL891

Series:

GSE1560

54 Samples

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