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| Status |
Public on Aug 23, 2008 |
| Title |
In vivo endothelial transcriptional profiles of porcine coronary and iliac arteries |
| Organism |
Sus scrofa |
| Experiment type |
Expression profiling by array
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| Summary |
Phenotypic heterogeneity among arterial ECs is particularly relevant to atherosclerosis since the disease occurs predominantly in major arteries, which vary in their atherosusceptibility. To explore EC heterogeneity, we used DNA microarrays to compare gene expression profiles of freshly harvested porcine coronary and iliac artery ECs. We demonstrate that in vivo the endothelial transcriptional profile of a coronary artery (the right coronary artery) is intrinsically different from that of a major conduit vessel (the external iliac artery), and that this difference is consistent with former vessel being more prone to atherosclerosis.
Keywords: coronary atherosclerosis, endothelial heterogeneity, microarray, gene expression
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| Overall design |
Endothelial cells were freshly harvest from right coronary, left and right iliac arteries from four pigs. RNA were isolated and expression profiles were obtained using olig microarrays.
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| Contributor(s) |
Zhang J, Burridge KA, Friedman MH |
| Citation(s) |
18689496 |
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| Submission date |
Mar 25, 2008 |
| Last update date |
Oct 14, 2012 |
| Contact name |
Ji Zhang |
| E-mail(s) |
ji.z@duke.edu
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| Phone |
919-660-5125
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| Fax |
919-684-4488
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| Organization name |
Duke University
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| Department |
Department of Biomedical Engineering
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| Lab |
Cardiovascular simulations
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| Street address |
Room 136 Hudson Hall
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| City |
Durham |
| State/province |
NC |
| ZIP/Postal code |
27708 |
| Country |
USA |
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| Platforms (1) |
| GPL3461 |
Duke Operon Porcine 10.5K Oligo Array |
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| Samples (12)
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| GSM277395 |
Endothelial cells from right coronary artery, rep 1 |
| GSM277396 |
Endothelial cells from left iliac artery, rep 1 |
| GSM277397 |
Endothelial cells from right iliac artery, rep 1 |
| GSM277398 |
Endothelial cells from right coronary artery, rep 2 |
| GSM277399 |
Endothelial cells from left iliac artery, rep 2 |
| GSM277400 |
Endothelial cells from right iliac artery, rep 2 |
| GSM277401 |
Endothelial cells from right coronary artery, rep 3 |
| GSM277402 |
Endothelial cells from left iliac artery, rep 3 |
| GSM277403 |
Endothelial cells from right iliac artery, rep 3 |
| GSM277404 |
Endothelial cells from right coronary artery, rep 4 |
| GSM277405 |
Endothelial cells from left iliac artery, rep 4 |
| GSM277406 |
Endothelial cells from right iliac artery, rep 4 |
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| Relations |
| BioProject |
PRJNA107249 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE10938_RAW.tar |
13.9 Mb |
(http)(custom) |
TAR (of GPR) |
| Processed data included within Sample table |
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