N-Octadecanoyl-D-phenylalanine - GEO DataSets

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The following terms were not found in GEO DataSets: Octadecanoyl, N-Octadecanoyl-D-phenylalanine.
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Select item 2002169911.

Small Molecule Inducers of Neuroprotective miR-132 Identified by HTS-HTS in Human iPSC-derived Neurons

(Submitter supplied) MicroRNAs (miRNAs) are short RNAs that regulate fundamental biological processes. miR-132, a key miRNA with established functions in Tau homeostasis and neuroprotection, is consistently downregulated in Alzheimer’s disease (AD) and other tauopathies. miR-132 overexpression rescues neurodegenerative phenotypes in several AD models. To complement research on miRNA-mimicking oligonucleotides targeting the central nervous system, we developed a high-throughput-screen coupled high-throughput-sequencing (HTS-HTS) in human induced pluripotent stem cell (iPSC)-derived neurons to identify small molecule inducers of miR-132. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL21697
1441 Samples

Download data: XLSX

Series

Accession:: GSE216991

ID:: 200216991

PubMed Full text in PMC Similar studies

Select item 2001222952.

Expression profiling to identify independent regulatory signals in Escherichia coli

(Submitter supplied) RNA sequencing was performed on E. coli K12 MG1655 with various supplements designed to activate transcriptional regulators

Organism:: Escherichia coli

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21433
30 Samples

Download data: CSV

Series

Accession:: GSE122295

ID:: 200122295

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000703993.

Phenotypic and genomic analysis of multiple myeloma minimal residual disease clonal plasma cells: a new model to understand chemoresistance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array; Expression profiling by array

Platforms:: GPL18637 GPL6244
30 Samples

Download data: CEL, CYCHP, TXT

Series

Accession:: GSE70399

ID:: 200070399

Select item 2000703974.

Phenotypic and genomic analysis of multiple myeloma minimal residual disease clonal plasma cells: a new model to understand chemoresistance [CytoScan750K Copy Number, LOH]

(Submitter supplied) Persistence of chemoresistant minimal residual disease (MRD) plasma cells (PCs) relates to inferior survival in multiple myeloma (MM). MRD PCs are therefore a minor clone able to recapitulate the initial tumor burden at relapse and accordingly, its characterization may represent a unique model to understand chemoresistance; unfortunately, the MRD clone has never been biologically investigated. Here, we compared the antigenic profile of MRD vs. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platform:: GPL18637
24 Samples

Download data: CEL, CYCHP, TXT

Series

Accession:: GSE70397

ID:: 200070397

PubMed Similar studies

Select item 2000639355.

Human pluripotent stem cell-derived neural constructs for predictive neurotoxicity screening

(Submitter supplied) Human pluripotent stem cell-based in vitro models that reflect human physiology have the potential to reduce the number of drug failures in clinical trials, and offer a cost effective approach for assessing chemical safety. Here, human embryonic stem (ES) cell-derived neural progenitor cells, endothelial cells, mesenchymal stem cells, and microglia/macrophage precursors were combined on chemically-defined poly(ethylene glycol) (PEG) hydrogels and cultured in serum-free media to model cellular interactions of the developing brain. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
303 Samples

Download data: XLSX

Series

Accession:: GSE63935

ID:: 200063935

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000612016.

Addition of IL-6 inhibition to standard GVHD prophylaxis to prevent GVHD after allogeneic stem cell transplantation

(Submitter supplied) BACKGROUND - IL-6 mediates graft-versus-host disease (GVHD) in experimental allogeneic stem cell transplantation (alloSCT) and is an attractive therapeutic target. METHODS - A registered phase I/II study (ACTRN12612000726853) of IL-6 receptor (IL-6R) neutralizing antibody administration on day -1 to patients receiving full or reduced-intensity conditioning (RIC) and alloSCT from HLA-matched sibling or unrelated donors with standard cyclosporin and methotrexate GVHD prophylaxis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
47 Samples

Download data: TXT

Series

Accession:: GSE61201

ID:: 200061201

Select item 2000599277.

Drug Matrix Data - CodeLink Arrays

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL5426 GPL5425 GPL5424
12921 Samples

Download data: TXT

Series

Accession:: GSE59927

ID:: 200059927

Analyze with GEO2R

Select item 2000599258.

Exposure of rat to a variety of toxicants, spleen assayed by Codelink microarray

(Submitter supplied) DrugMatrix is a comprehensive rat toxicogenomics database and analysis tool developed to facilitate the integration of toxicogenomics into hazard assessment. Using the whole genome and a diverse set of compounds allows a comprehensive view of most pharmacological and toxicological questions and is applicable to other situations such as disease and development.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL5426 GPL5425
562 Samples

Download data: TXT

Series

Accession:: GSE59925

ID:: 200059925

Analyze with GEO2R

Select item 2000599239.

Exposure of rat to a variety of toxicants, liver assayed by Codelink microarray

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL5424 GPL5426 GPL5425
5265 Samples

Download data: TXT

Series

Accession:: GSE59923

ID:: 200059923

Analyze with GEO2R

Select item 20005991310.

Exposure of rat to a variety of toxicants, kidney assayed by CodeLink microarray

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL5426 GPL5425 GPL5424
2862 Samples

Download data: TXT

Series

Accession:: GSE59913

ID:: 200059913

Analyze with GEO2R

Select item 20005990511.

Exposure of rat to a variety of toxicants, heart assayed by CodeLink microarray

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL5425 GPL5426
2051 Samples

Download data: TXT

Series

Accession:: GSE59905

ID:: 200059905

Analyze with GEO2R

Select item 20005989412.

Exposure of rat to a variety of toxicants, bone marrow assayed by CodeLink microarray

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL5426 GPL5425
983 Samples

Download data: TXT

Series

Accession:: GSE59894

ID:: 200059894

Analyze with GEO2R

Select item 20002431513.

Lai - CMEL1/BS28

(Submitter supplied) modENCODE_submission_2820 This submission comes from a modENCODE project of Eric Lai. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We plan to generate a comprehensive catalog of expressed and functional microRNAs, and generate biological evidence for their regulatory activity. We plan also to delineate the primary transcription units of microRNA genes. Finally, we plan to annotate other classes of non-miRNA expressed small RNAs, as least some of which may define novel classes of small RNA genes. more...

Organism:: Drosophila melanogaster

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL9058
1 Sample

Download data: SAM

Series

Accession:: GSE24315

ID:: 200024315

modENCODE SRA Run Selector

Select item 20002430114.

Drosophila melanogaster small RNA sequence

(Submitter supplied) modENCODE_submission_3193 This submission comes from a modENCODE project of Eric Lai. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We plan to generate a comprehensive catalog of expressed and functional microRNAs, and generate biological evidence for their regulatory activity. We plan also to delineate the primary transcription units of microRNA genes. Finally, we plan to annotate other classes of non-miRNA expressed small RNAs, as least some of which may define novel classes of small RNA genes. more...

Organism:: Drosophila melanogaster

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL9058
2 Samples

Download data: SAM

Series

Accession:: GSE24301

ID:: 200024301

modENCODE SRA Run Selector

Select item 20002429815.

Lai - MLDmD20c5/BS16

(Submitter supplied) modENCODE_submission_2002 This submission comes from a modENCODE project of Eric Lai. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We plan to generate a comprehensive catalog of expressed and functional microRNAs, and generate biological evidence for their regulatory activity. We plan also to delineate the primary transcription units of microRNA genes. Finally, we plan to annotate other classes of non-miRNA expressed small RNAs, as least some of which may define novel classes of small RNA genes. more...

Organism:: Drosophila melanogaster

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL9058
1 Sample

Download data: SAM

Series

Accession:: GSE24298

ID:: 200024298

modENCODE SRA Run Selector

Select item 20001929316.

In-transit extremity melanoma II

(Submitter supplied) An evaluation of biopsies from patients with in-transit extremity melanoma who have been treated with melphalan in the setting of isolated limb infusion Gene expression profiles were obtained from 52 lesions across 28 patients and evaluated for expression values that correlated with response to melphalan isolated limb infusion

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
52 Samples

Download data: CEL

Series

Accession:: GSE19293

ID:: 200019293

Select item 20001145217.

Saccharomyces cerevisiae chemostat steady state microarray compendium

(Submitter supplied) Background Microorganisms adapt their transcriptome by integrating multiple chemical and physical signals from their environment. Shake-flask cultivation does not allow precise manipulation of individual culture parameters and therefore precludes a quantitative analysis of the (combinatorial) influence of these parameters on transcriptional regulation. Steady-state chemostat cultures, which do enable accurate control, measurement and manipulation of individual cultivation parameters (e.g. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL90
170 Samples

Download data: CEL, CHP, EXP

Series

Accession:: GSE11452

ID:: 200011452

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000885818.

Liver Pharmacology and Xenobiotic Response Repertoire

(Submitter supplied) A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology. We have used a supervised classification approach to systematically mine a large microarray database derived from livers of compound-treated rats. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL5425 GPL5426 GPL5424
5312 Samples

Download data

Series

Accession:: GSE8858

ID:: 200008858

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000959019.

Saccharomyces cerevisiae TPP 2-oxo acid decarboxylases

(Submitter supplied) The irreversible decarboxylation step, which commits 2-oxo acids to the Ehrlich pathway, was initially attributed to pyruvate decarboxylase. However, the yeast genome was shown to harbour no fewer than 5 genes that show sequence similarity with thiamine-diphosphate dependent decarboxylase genes. Three of these (PDC1, PDC5 and PDC6) encode pyruvate decarboxylases { while ARO10 and THI3 represent alternative candidates for Ehrlich-pathway decarboxylases. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL90
12 Samples

Download data: CEL, EXP

Series

Accession:: GSE9590

ID:: 200009590

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000825120.

Non-genotoxic Hepatocarcinogens

(Submitter supplied) There is no accurate and well-validated short-term test for non-genotoxic carcinogens, necessitating an expensive two year rodent bioassay before a risk assessment can begin. We have developed a short-term in vivo rat assay that predicts whether non-genotoxic chemicals are likely to induce hepatic tumors based on transcript profiles in the liver. Using a large independent test set, assay accuracy was found to be superior to existing pathological and genomic markers. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL5426 GPL5424 GPL5425
990 Samples

Download data: TXT

Series

Accession:: GSE8251

ID:: 200008251

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