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- Substudies
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phs000249.v3.p1 : NABEC: Genome-Wide Genotyping phs001301.v1.p1 : NABEC Exome Sequencing of Human Cerebral Frontal Cortex phs001302.v1.p1 : NABEC CAGE Sequencing of Human Cerebral Frontal Cortex phs001353.v1.p1 : NABEC mRNA Sequencing of Human Cerebral Frontal Cortex phs001354.v1.p1 : NABEC Total RNA Sequencing of Human Cerebral Frontal Cortex phs001462.v1.p1 : NABEC NeuroChip Genotyping - Study Description
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Important Links and Information
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Request access via Authorized Access
- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
This study utilized neurologically normal control samples deposited in North American Brain Expression Consortium (NABEC). This top-level study, phs001300, makes available all phenotype data of the NABEC study participants.
In addition, molecular data of six sub-studies are available through dbGaP:- NABEC Genome-Wide Genotyping - phs000249
- NABEC Exome Sequencing - phs001301
- NABEC CAGE Sequencing of Human Cerebral Frontal Cortex - phs001302
- NABEC mRNA Sequencing of human Cerebral Frontal Cortex - phs001353
- NABEC Total RNA Sequencing of human Cerebral Frontal Cortex - phs001354
- NABEC Neurochip Genotyping - phs001462
- Study Design:
- Control Set
- Study Type:
- Control Set
- Total number of consented subjects: 432
- Subject Sample Telemetry Report (SSTR)
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Request access via Authorized Access
- Authorized Access
- Publicly Available Data
- Study Inclusion/Exclusion Criteria
Neurologically normal control individuals only.
- Molecular Data
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Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Whole Genome Genotyping Illumina HumanHap550v3.0 561466 51468 Whole Genome Genotyping Illumina Human610_Quadv1_B 601273 1048904 Whole Genome Genotyping Illumina Human660W-Quad_v1_A 592839 1048965 Whole Exome Sequencing Illumina Nextera Rapid Capture Exome N/A N/A Whole Exome Sequencing Illumina TruSeq N/A N/A CAGE RNA Sequencing Illumina HiSeq 2000 N/A N/A Cap analysis gene expression - https://www.ncbi.nlm.nih.gov/pubmed/22362160 Total RNA Sequencing Illumina TruSeq Stranded Total RNA with Ribo-Zero Globin N/A N/A mRNA Sequencing Illumina TruSeq Stranded mRNA Sample Prep Kit N/A N/A Targeted Genotyping Illumina Infinium Neuro Consortium Array N/A N/A See: Blaudraat et al., 20017, https://www.ncbi.nlm.nih.gov/pubmed/28602509 - Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
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- Primary Phenotype: Gene Expression Profiling
- Authorized Data Access Requests
- Study Attribution
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Principal Investigators
- J. Raphael Gibbs. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA and Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London, London, UK.
- Marcel P. van der Brug. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA and Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, Jupiter, FL, USA.
- Dena G. Hernandez. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA and Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London, London, UK.
- Bryan J. Traynor. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
- Michael A. Nalls. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
- Shiao-Lin Lai. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA and Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London, London, UK.
- Sampath Arepalli. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
- Allissa Dillman. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
- Ian P. Rafferty. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
- Juan Troncoso. Division of Neuropathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
- Robert Johnson. NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School, Baltimore, MD, USA.
- H. Ronald Zielke. NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School, Baltimore, MD, USA.
- Luigi Ferrucci. Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA.
- Dan L. Longo. Lymphocyte Cell Biology Unit, Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
- Mark R. Cookson. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
- Andrew B. Singleton. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
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Institutes
- National Institute on Aging, Bethesda, MD, USA.
- Institute of Neurology, University College London, London, UK.
- The Scripps Research Institute, Jupiter, FL, USA.
- Johns Hopkins University, Baltimore, MD, USA.
- University of Maryland Medical School, Baltimore, MD, USA.
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Funding Source
- Z01 AG000949-02. National Institutes of Health, Bethesda, MD, USA.
- Z01 AG000015-49. National Institutes of Health, Bethesda, MD, USA.
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Principal Investigators