NABEC: Genome-Wide Genotyping

This sub-study contains genotypes for 382 neurologically healthy control samples deposited from the North American Brain Expression Consortium (NABEC). Here, we release the raw genotype data of these control individuals where the genotypes were assayed on Illumina genome-wide genotyping arrays.

Previous Study Name: Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain. Phenotype data are available through "NABEC: North American Brain Expression Consortium" (phs001300)

• Study Design:
  • Control Set
• Study Type:
  • Control Set
• dbGaP estimated ancestry using GRAF-pop
• Total number of consented subjects: 382
• Subject Sample Telemetry Report (SSTR)

• BioSample

• Version 1 study release included SNP - array data of n=150 subjects.
• Version 2 study release included SNP - array data of additional n=232 subjects.
• Version 3 study release includes exome sequencing and .vcf data of n=318 (n=313) subjects, respectively. The study has also become a substudy of the NABEC cohort.
• Additional data have been deposited to NCBI/GEO.

• Primary Phenotype: Healthy Volunteers
• DNA Methylation
• Quantitative Trait Loci

• Principal Investigators
  • Mark R. Cookson. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Andrew B. Singleton. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
• Co-Investigators
  • J. Raphael Gibbs. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA and Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London, London, UK.
  • Marcel P. van der Brug. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, and Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, Jupiter, FL, USA.
  • Dena G. Hernandez. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA and Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London, London, UK.
  • Bryan J. Traynor. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Michael A. Nalls. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Shiao-Lin Lai. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA, and Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London, London, UK.
  • Sampath Arepalli. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Allissa Dillman. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Ian P. Rafferty. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Juan Troncoso. Division of Neuropathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
  • Robert Johnson. NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School, Baltimore, MD, USA.
  • H. Ronald Zielke. NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School, Baltimore, MD, USA.
  • Luigi Ferrucci. Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA.
  • Dan L. Longo. Lymphocyte Cell Biology Unit, Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
• Institutes
  • National Institute on Aging, Bethesda, MD, USA.
  • Institute of Neurology, University College London, London, UK.
  • The Scripps Research Institute, Jupiter, FL, USA.
  • Johns Hopkins University, Baltimore, MD, USA.
  • University of Maryland Medical School, Baltimore, MD, USA.
• Funding Sources
  • Z01 AG000949-02. National Institutes of Health, Bethesda, MD, USA.
  • Z01 AG000015-49. National Institutes of Health, Bethesda, MD, USA.